Epigenetic Inactivation of the CpG Demethylase TET1 as a DNA Methylation Feedback Loop in Upper Aerodigestive Tract and Gastrointestinal Cancers

2017 ◽  
Vol 15 (1) ◽  
pp. e46
Author(s):  
Lili Li ◽  
Chen Li ◽  
Haitao Mao ◽  
Zhenfang Du ◽  
Wai Yee Chan ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Feedback Loop ◽  
Aerodigestive Tract ◽  
Gastrointestinal Cancers ◽  
Upper Aerodigestive Tract ◽  
Epigenetic Inactivation

scholarly journals DNA methylation changes associated with risk factors in tumors of the upper aerodigestive tract

Epigenetics ◽  
2012 ◽  
Vol 7 (3) ◽  
pp. 270-277 ◽  
Author(s):  
Samson Mani ◽  
Kasia Szymańska ◽  
Cyrille Cuenin ◽  
David Zaridze ◽  
Karen Balassiano ◽  
...  
Keyword(s):  
Risk Factors ◽  
Dna Methylation ◽  
Aerodigestive Tract ◽  
Upper Aerodigestive Tract

scholarly journals Upper Aerodigestive Tract Squamous Cell Carcinomas Show Distinct Overall DNA Methylation Profiles and Different Molecular Mechanisms behind WNT Signaling Disruption

Cancers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 3014
Author(s):  
Sheila Coelho Soares-Lima ◽  
Hisham Mehanna ◽  
Diego Camuzi ◽  
Paulo Thiago de Souza-Santos ◽  
Tatiana de Almeida Simão ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Wnt Signaling ◽  
Signaling Pathways ◽  
Squamous Cell ◽  
Molecular Mechanisms ◽  
Genetic Alterations ◽  
Squamous Cell Carcinomas ◽  
Aerodigestive Tract ◽  
Upper Aerodigestive Tract ◽  
Genome Wide

Upper aerodigestive tract (UADT) tumors present different biological behavior and prognosis, suggesting specific molecular mechanisms underlying their development. However, they are rarely considered as single entities (particularly head and neck subsites) and share the most common genetic alterations. Therefore, there is a need for a better understanding of the global DNA methylation differences among UADT tumors. We performed a genome-wide DNA methylation analysis of esophageal (ESCC), laryngeal (LSCC), oral (OSCC) and oropharyngeal (OPSCC) squamous cell carcinomas, and their non-tumor counterparts. The unsupervised analysis showed that non-tumor tissues present markedly distinct DNA methylation profiles, while tumors are highly heterogeneous. Hypomethylation was more frequent in LSCC and OPSCC, while ESCC and OSCC presented mostly hypermethylation, with the latter showing a CpG island overrepresentation. Differentially methylated regions affected genes in 127 signaling pathways, with only 3.1% of these being common among different tumor subsites, but with different genes affected. The WNT signaling pathway, known to be dysregulated in different epithelial tumors, is a frequent hit for DNA methylation and gene expression alterations in ESCC and OPSCC, but mostly for genetic alterations in LSCC and OSCC. UADT tumor subsites present differences in genome-wide methylation regarding their profile, intensity, genomic regions and signaling pathways affected.

scholarly journals Erratum: Corrigendum: Epigenetic inactivation of the CpG demethylase TET1 as a DNA methylation feedback loop in human cancers

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Lili Li ◽  
Chen Li ◽  
Haitao Mao ◽  
Zhenfang Du ◽  
Wai Yee Chan ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Feedback Loop ◽  
Epigenetic Inactivation ◽  
Human Cancers

Carcinogenesis in the Upper Aerodigestive Tract

1980 ◽  
Vol 13 (3) ◽  
pp. 403-412 ◽  
Author(s):  
Charles W. Vaughan ◽  
Freddy Homburger ◽  
Stanley M. Shapshay ◽  
Enrique Soto ◽  
Peter Bernfeld
Keyword(s):  
Aerodigestive Tract ◽  
Upper Aerodigestive Tract

Precursor Lesions for Squamous Carcinoma in the Upper Aerodigestive Tract

2021 ◽  
pp. 1-62
Author(s):  
Edward Odell ◽  
Nina Gale ◽  
Selvam Thavaraj ◽  
Alfons Nadal ◽  
Nina Zidar ◽  
...  
Keyword(s):  
Squamous Carcinoma ◽  
Aerodigestive Tract ◽  
Precursor Lesions ◽  
Upper Aerodigestive Tract

scholarly journals Atypical Clinical Presentation of Laryngopharyngeal Reflux: A 5-Year Case Series

2021 ◽  
Vol 10 (11) ◽  
pp. 2439
Author(s):  
Jerome R. Lechien ◽  
Stéphane Hans ◽  
Francois Bobin ◽  
Christian Calvo-Henriquez ◽  
Sven Saussez ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Laryngopharyngeal Reflux ◽  
Case Series ◽  
Clinical Findings ◽  
Aerodigestive Tract ◽  
Common Disease ◽  
Upper Aerodigestive Tract ◽  
Suppurative Otitis Media ◽  
Adequate Treatment ◽  
Atypical Clinical Presentation

Background: Laryngopharyngeal reflux (LPR) is a common disease in otolaryngology characterized by an inflammatory reaction of the mucosa of the upper aerodigestive tract caused by digestive refluxate enzymes. LPR has been identified as the etiological or favoring factor of laryngeal, oral, sinonasal, or otological diseases. In this case series, we reported the atypical clinical presentation of LPR in patients presenting in our clinic with reflux. Methods: A retrospective medical chart review of 351 patients with LPR treated in the European Reflux Clinic in Brussels, Poitiers and Paris was performed. In order to be included, patients had to report an atypical clinical presentation of LPR, consisting of symptoms or findings that are not described in the reflux symptom score and reflux sign assessment. The LPR diagnosis was confirmed with a 24 h hypopharyngeal-esophageal impedance pH study, and patients were treated with a combination of diet, proton pump inhibitors, and alginates. The atypical symptoms or findings had to be resolved from pre- to posttreatment. Results: From 2017 to 2021, 21 patients with atypical LPR were treated in our center. The clinical presentation consisted of recurrent aphthosis or burning mouth (N = 9), recurrent burps and abdominal disorders (N = 2), posterior nasal obstruction (N = 2), recurrent acute suppurative otitis media (N = 2), severe vocal fold dysplasia (N = 2), and recurrent acute rhinopharyngitis (N = 1), tearing (N = 1), aspirations (N = 1), or tracheobronchitis (N = 1). Abnormal upper aerodigestive tract reflux events were identified in all of these patients. Atypical clinical findings resolved and did not recur after an adequate antireflux treatment. Conclusion: LPR may present with various clinical presentations, including mouth, eye, tracheobronchial, nasal, or laryngeal findings, which may all regress with adequate treatment. Future studies are needed to better specify the relationship between LPR and these atypical findings through analyses identifying gastroduodenal enzymes in the inflamed tissue.

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