scholarly journals New Directions for Neurodegenerative Disease Therapy: Using Chemical Compounds to Boost the Formation of Mutant Protein Inclusions

Cell Cycle ◽  
2006 ◽  
Vol 5 (14) ◽  
pp. 1477-1480 ◽  
Author(s):  
Ruth A. Bodner ◽  
David E. Housman ◽  
Aleksey G. Kazantsev
Keyword(s):  
Neurodegenerative Disease ◽  
Chemical Compounds ◽  
Mutant Protein ◽  
Disease Therapy ◽  
New Directions

scholarly journals Prospects for the Use of Medical Clays (Review)

2019 ◽  
Vol 8 (4) ◽  
pp. 27-31 ◽  
Author(s):  
A. V. Bondarev ◽  
E. T. Zhilyakova ◽  
N. B. Demina ◽  
E. Yu. Timoshenko
Keyword(s):  
Raw Materials ◽  
Chemical Compounds ◽  
Food Technology ◽  
Mineral Raw Materials ◽  
Promising Direction ◽  
Pharmaceutical Substances ◽  
Pharmaceutical Technology ◽  
New Directions ◽  
Scientific Significance ◽  
Cutaneous Application

Introduction. The article deals with the aspects of the use of Medical Clays in Pharmaceutical Technology. A review of the traditional areas of application of Medical Clay, as well as highlighting new directions.Text. One of the main problems of domestic industrial pharmacy is a narrow nomenclature of active pharmaceutical substances and excipients. Replenishment of the nomenclature occurs in two ways-through the synthesis of new chemical compounds or through the processing of natural raw materials of animal, plant or mineral origin. In the process of purification and processing of mineral raw materials, Medical Clays are obtained, which are now widely used as active pharmaceutical substances for the production of Enterosorbents, as well as auxiliary substances.Conclusion. A review of perspectives and areas of use of Medicinal Clays have shown that at present, Medical Clays used in the three traditional areas: cutaneous application, application per os, application in pharmaceutical and food technology. A promising direction is the use of Medical Clays as transport drug systems. The study of this information array and its generalization has undoubted practical and scientific significance in modern pharmaceutical technology. 

scholarly journals Acute versus Chronic Exposures to Inhaled Particulate Matter and Neurocognitive Dysfunction: Pathways to Alzheimer’s Disease or a Related Dementia

2020 ◽  
Vol 78 (3) ◽  
pp. 871-886
Author(s):  
Minos Kritikos ◽  
Samuel E. Gandy ◽  
Jaymie R. Meliker ◽  
Benjamin J. Luft ◽  
Sean A.P. Clouston
Keyword(s):  
Air Pollution ◽  
Particulate Matter ◽  
Neurodegenerative Disease ◽  
World Trade Center ◽  
Neurocognitive Dysfunction ◽  
Disease Case ◽  
New Directions ◽  
The Central Nervous System ◽  
Trade Center ◽  
Aging World

An estimated 92% of the world’s population live in regions where people are regularly exposed to high levels of anthropogenic air pollution. Historically, research on the effects of air pollution have focused extensively on cardiovascular and pulmonary health. However, emerging evidence from animal and human studies has suggested that chronic exposures to air pollution detrimentally change the functioning of the central nervous system with the result being proteinopathy, neurocognitive impairment, and neurodegenerative disease. Case analyses of aging World Trade Center responders suggests that a single severe exposure may also induce a neuropathologic response. The goal of this report was to explore the neuroscientific support for the hypothesis that inhaled particulate matter might cause an Alzheimer’s-like neurodegenerative disease, in order to consider proposed mechanisms and latency periods linking inhaled particulate matter and neurodegeneration, and to propose new directions in this line of research.

scholarly journals Acute versus Chronic Exposures to Inhaled Particulate Matter and Neurocognitive Dysfunction: Pathways to Alzheimer’s Disease or a Related Dementia

2021 ◽  
Author(s):  
Minos Kritikos ◽  
Samuel E. Gandy ◽  
Jaymie R. Meliker ◽  
Benjamin J. Luft ◽  
Sean A.P. Clouston
Keyword(s):  
Air Pollution ◽  
Particulate Matter ◽  
Neurodegenerative Disease ◽  
World Trade Center ◽  
Neurocognitive Dysfunction ◽  
Disease Case ◽  
New Directions ◽  
The Central Nervous System ◽  
Trade Center ◽  
Aging World

An estimated 92% of the world’s population live in regions where people are regularly exposed to high levels of anthropogenic air pollution. Historically, research on the effects of air pollution have focused extensively on cardiovascular and pulmonary health. However, emerging evidence from animal and human studies has suggested that chronic exposures to air pollution detrimentally change the functioning of the central nervous system with the result being proteinopathy, neurocognitive impairment, and neurodegenerative disease. Case analyses of aging World Trade Center responders suggests that a single severe exposure may also induce a neuropathologic response. The goal of this report was to explore the neuroscientific support for the hypothesis that inhaled particulate matter might cause an Alzheimer’s-like neurodegenerative disease, in order to consider proposed mechanisms and latency periods linking inhaled particulate matter and neurodegeneration, and to propose new directions in this line of research.

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