scholarly journals Medicinal chemistry advances in neurodegenerative disease therapy: part 2

2017 ◽  
Vol 9 (10) ◽  
pp. 951-952 ◽  
Author(s):  
Rachel Coleby
Keyword(s):  
Neurodegenerative Disease ◽  
Medicinal Chemistry ◽  
Disease Therapy

scholarly journals Proposed Therapies for Pantothenate-Kinase-Associated Neurodegeneration

2019 ◽  
Vol 13 ◽  
pp. 117906951985111 ◽  
Author(s):  
Suzanne Jackowski
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Drug Discovery ◽  
Neurodegenerative Disease ◽  
Blood Brain Barrier ◽  
Medicinal Chemistry ◽  
Clinical Development ◽  
Brain Barrier ◽  
Pantothenate Kinase ◽  
Blood Brain

Multiple approaches to therapy have been proposed for the rare inherited neurodegenerative disease associated with mutations in the PANK2 gene, called pantothenate-kinase-associated neurodegeneration (PKAN). Penetration of the blood-brain barrier for treatment of a central nervous system (CNS) disorder is a major challenge in drug discovery. Evaluation of the biochemistry and medicinal chemistry of the proposed therapies reveals potential liabilities among several compounds under consideration for clinical development.

scholarly journals Prion‐like mechanisms in neurodegenerative disease: Implications for Huntington's disease therapy

2020 ◽  
Vol 9 (5) ◽  
pp. 559-566
Author(s):  
Bhairavi Srinageshwar ◽  
Robert B. Petersen ◽  
Gary L. Dunbar ◽  
Julien Rossignol
Keyword(s):  
Neurodegenerative Disease ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Disease Therapy
Sign in / Sign up

Export Citation Format

Share Document