Neural Transplantation in Neurodegenerative Disease: Current Status and New Directions

Planta Medica ◽  
2013 ◽  
Vol 79 (10) ◽  
Author(s):  
CM Coleman ◽  
KM Auker ◽  
D Ferreira

Author(s):  
Carolyn Dillian

This article discusses the current status of archaeological obsidian studies, including techniques used in characterization and sourcing studies, obsidian hydration, and regional syntheses. It begins with an overview of obsidian and the unique formation processes that create it before turning to a discussion of the significance of characterization and sourcing techniques for understanding prehistoric obsidian trade and exchange. It then considers the problematic aspects of the term “sourcing,” despite its ubiquitous use in archaeology and archaeometry, along with the use of X-ray fluorescence in the chemical characterization of obsidian. It also explores obsidian hydration dating methods and equations, factors that can affect the date assignments for hydration specimens, and the various uses of obsidian in prehistoric times. Finally, it addresses some important questions relating to obsidian research and suggests new directions in the field.


2020 ◽  
Vol 78 (3) ◽  
pp. 871-886
Author(s):  
Minos Kritikos ◽  
Samuel E. Gandy ◽  
Jaymie R. Meliker ◽  
Benjamin J. Luft ◽  
Sean A.P. Clouston

An estimated 92% of the world’s population live in regions where people are regularly exposed to high levels of anthropogenic air pollution. Historically, research on the effects of air pollution have focused extensively on cardiovascular and pulmonary health. However, emerging evidence from animal and human studies has suggested that chronic exposures to air pollution detrimentally change the functioning of the central nervous system with the result being proteinopathy, neurocognitive impairment, and neurodegenerative disease. Case analyses of aging World Trade Center responders suggests that a single severe exposure may also induce a neuropathologic response. The goal of this report was to explore the neuroscientific support for the hypothesis that inhaled particulate matter might cause an Alzheimer’s-like neurodegenerative disease, in order to consider proposed mechanisms and latency periods linking inhaled particulate matter and neurodegeneration, and to propose new directions in this line of research.


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