scholarly journals Re-Evaluating the Role of Frat in Wnt-Signal Transduction

Cell Cycle ◽  
2005 ◽  
Vol 4 (8) ◽  
pp. 4065-4072 ◽  
Author(s):  
Renée van Amerongen ◽  
Anton Berns
Keyword(s):  
Signal Transduction ◽  
Wnt Signal

scholarly journals Evaluating the Role of Wnt Signal Transduction in Promoting the Development of the Heart

2007 ◽  
Vol 7 ◽  
pp. 161-176 ◽  
Author(s):  
Leonard M. Eisenberg ◽  
Carol A. Eisenberg
Keyword(s):  
Signal Transduction ◽  
Planar Cell Polarity ◽  
Cardiac Development ◽  
Experimental Studies ◽  
Stem Cell Differentiation ◽  
Wnt Proteins ◽  
And Function ◽  
Canonical Wnt ◽  
Wnt Signal

Wnts are a family of secreted signaling proteins that are encoded by 19 distinct genes in the vertebrate genome. These molecules initiate several signal transduction pathways: the canonical Wnt, Wnt/Ca2+, and Wnt/planar cell polarity pathways. Wnt proteins have major impact on embryonic development, tumor progression, and stem cell differentiation. Wnt signal transduction also influences the formation of the heart, yet many issues concerning the involvement of Wnt regulation in initiating cardiac development remain unresolved. In this review, we will examine the published record to discern (a) what has been shown by experimental studies on the participation of Wnt signaling in cardiogenesis, and (b) what are the important questions that need to be addressed to understand the importance and function of Wnt signal transduction in facilitating the development of the heart.

scholarly journals cROStalk for Life: Uncovering ROS Signaling in Plants and Animal Systems, from Gametogenesis to Early Embryonic Development

Genes ◽  
2021 ◽  
Vol 12 (4) ◽  
pp. 525
Author(s):  
Valentina Lodde ◽  
Piero Morandini ◽  
Alex Costa ◽  
Irene Murgia ◽  
Ignacio Ezquer
Keyword(s):  
Signal Transduction ◽  
Signaling Pathways ◽  
Analytical Techniques ◽  
Antioxidant Systems ◽  
Developmental Studies ◽  
Science Field ◽  
Ros Signaling ◽  
Reproductive Processes

This review explores the role of reactive oxygen species (ROS)/Ca2+ in communication within reproductive structures in plants and animals. Many concepts have been described during the last years regarding how biosynthesis, generation products, antioxidant systems, and signal transduction involve ROS signaling, as well as its possible link with developmental processes and response to biotic and abiotic stresses. In this review, we first addressed classic key concepts in ROS and Ca2+ signaling in plants, both at the subcellular, cellular, and organ level. In the plant science field, during the last decades, new techniques have facilitated the in vivo monitoring of ROS signaling cascades. We will describe these powerful techniques in plants and compare them to those existing in animals. Development of new analytical techniques will facilitate the understanding of ROS signaling and their signal transduction pathways in plants and mammals. Many among those signaling pathways already have been studied in animals; therefore, a specific effort should be made to integrate this knowledge into plant biology. We here discuss examples of how changes in the ROS and Ca2+ signaling pathways can affect differentiation processes in plants, focusing specifically on reproductive processes where the ROS and Ca2+ signaling pathways influence the gametophyte functioning, sexual reproduction, and embryo formation in plants and animals. The study field regarding the role of ROS and Ca2+ in signal transduction is evolving continuously, which is why we reviewed the recent literature and propose here the potential targets affecting ROS in reproductive processes. We discuss the opportunities to integrate comparative developmental studies and experimental approaches into studies on the role of ROS/ Ca2+ in both plant and animal developmental biology studies, to further elucidate these crucial signaling pathways.

scholarly journals Critical role of the membrane-proximal, proline-rich motif of the interleukin-2 receptor γc chain in the Jak3-independent signal transduction

1999 ◽  
Vol 4 (6) ◽  
pp. 363-373 ◽  
Author(s):  
Shiho Tsujino ◽  
Tadaaki Miyazaki ◽  
Atsuo Kawahara ◽  
Michiyuki Maeda ◽  
Tadatsugu Taniguchi ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Critical Role ◽  
Interleukin 2 ◽  
Interleukin 2 Receptor
Sign in / Sign up

Export Citation Format

Share Document