scholarly journals The Role of Ryk and Ror Receptor Tyrosine Kinases in Wnt Signal Transduction

2013 ◽  
Vol 6 (2) ◽  
pp. a009175-a009175 ◽  
Author(s):  
J. Green ◽  
R. Nusse ◽  
R. van Amerongen
Keyword(s):  
Signal Transduction ◽  
Tyrosine Kinases ◽  
Receptor Tyrosine Kinases ◽  
Wnt Signal

scholarly journals The relative role of ErbB1–4 receptor tyrosine kinases in radiation signal transduction responses of human carcinoma cells

Oncogene ◽  
2001 ◽  
Vol 20 (11) ◽  
pp. 1388-1397 ◽  
Author(s):  
G Bowers ◽  
D Reardon ◽  
T Hewitt ◽  
P Dent ◽  
R B Mikkelsen ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Tyrosine Kinases ◽  
Receptor Tyrosine Kinases ◽  
Carcinoma Cells ◽  
Relative Role ◽  
Human Carcinoma

scholarly journals Erratum: The relative role of ErbB1–4 receptor tyrosine kinases in radiation signal transduction responses of human carcinoma cells

Oncogene ◽  
2001 ◽  
Vol 20 (29) ◽  
pp. 3927-3927
Author(s):  
G Bowers ◽  
D Reardon ◽  
T Hewitt ◽  
P Dent ◽  
R B Mikkelsen ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Tyrosine Kinases ◽  
Receptor Tyrosine Kinases ◽  
Carcinoma Cells ◽  
Relative Role ◽  
Human Carcinoma

Signaling in new directions

1995 ◽  
Vol 73 (3-4) ◽  
pp. 133-136 ◽  
Author(s):  
Haleh Vahidi Samiei
Keyword(s):  
Gene Expression ◽  
Signal Transduction ◽  
Tyrosine Kinase ◽  
Map Kinase ◽  
Receptor Tyrosine Kinase ◽  
Tyrosine Kinases ◽  
Receptor Tyrosine Kinases ◽  
Molecular Level ◽  
Clear Cut ◽  
New Directions

Many laboratories, using a variety of organisms, have contributed to deciphering the identity and the order of the components leading from ligand-bound receptor tyrosine kinases to various intracellular events, including changes in gene expression. The gaps have only been filled recently. This minireview summarizes the findings and points out the degree of conservation of the same pathway in distant organisms, both at the molecular level and in terms of the consecutive steps. The review also looks at points at which this pathway might be diverging and points onto which other pathways might be converging. These interactions are not always clear cut, and understanding them will be the challenge for the future.Key words: signal transduction, receptor tyrosine kinase, RAS, RAF, MAP kinase.

scholarly journals Receptor Tyrosine Kinases in Kidney Development

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Renfang Song ◽  
Samir S. El-Dahr ◽  
Ihor V. Yosypiv
Keyword(s):  
Tyrosine Kinases ◽  
Molecular Mechanisms ◽  
Kidney Development ◽  
Receptor Tyrosine Kinases ◽  
Adaptor Proteins ◽  
Downstream Signaling ◽  
Arterial Blood ◽  
Intracellular Signal ◽  
Human Birth

The kidney plays a fundamental role in the regulation of arterial blood pressure and fluid/electrolyte homeostasis. As congenital anomalies of the kidney and urinary tract (CAKUT) constitute one of the most common human birth defects, improved understanding of the cellular and molecular mechanisms that lead to CAKUT is critical. Accumulating evidence indicates that aberrant signaling via receptor tyrosine kinases (RTKs) is causally linked to CAKUT. Upon activation by their ligands, RTKs dimerize, undergo autophosphorylation on specific tyrosine residues, and interact with adaptor proteins to activate intracellular signal transduction pathways that regulate diverse cell behaviours such as cell proliferation, survival, and movement. Here, we review the current understanding of role of RTKs and their downstream signaling pathways in the pathogenesis of CAKUT.

scholarly journals Signal Transduction Mechanisms in Mesenchymal Cells

1994 ◽  
Vol 5 (3) ◽  
pp. 291-310 ◽  
Author(s):  
Bradley S. McAllister ◽  
John D. Walters ◽  
Merle S. Olson
Keyword(s):  
Signal Transduction ◽  
Phospholipase D ◽  
Tyrosine Kinases ◽  
Receptor Tyrosine Kinases ◽  
Wide Spectrum ◽  
Mesenchymal Cells ◽  
Signal Transduction Pathways ◽  
Regenerative Therapy ◽  
Initial Signal ◽  
Transduction Mechanisms

Mesenchymal cells are continually stimulated by a wide spectrum of biological mediators. These mediators bind to receptors on the cell surface and initiate a cascade of signaling events. The initial signal transduction pathways known to be stimulated in mesenchymal cells include phospholipase C, phospholipase D, phospholipase A2, adenylate cyclase, receptor tyrosine kinases, and receptor serine/threonine kinases. These pathways are reviewed and specific applications for therapeutic intervention in wound healing and regenerative therapy in the periodontium are discussed.

scholarly journals The Role of Receptor Tyrosine Kinases in Lassa Virus Cell Entry

Viruses ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 857 ◽  
Author(s):  
Chiara Fedeli ◽  
Hector Moreno ◽  
Stefan Kunz
Keyword(s):  
Tyrosine Kinases ◽  
Receptor Tyrosine Kinases ◽  
Complex Function ◽  
Hemorrhagic Fever ◽  
Receptor Expression ◽  
Cell Entry ◽  
Lassa Virus ◽  
Emerging Viruses ◽  
Extracellular Matrix Molecule

The zoonotic Old World mammarenavirus Lassa (LASV) causes severe hemorrhagic fever with high mortality and morbidity in humans in endemic regions. The development of effective strategies to combat LASV infections is of high priority, given the lack of a licensed vaccine and restriction on available treatment to off-label use of ribavirin. A better understanding of the fundamental aspects of the virus’s life cycle would help to improve the development of novel therapeutic approaches. Host cell entry and restriction factors represent major barriers for emerging viruses and are promising targets for therapeutic intervention. In addition to the LASV main receptor, the extracellular matrix molecule dystroglycan (DG), the phosphatidylserine-binding receptors of the Tyro3/Axl/Mer (TAM), and T cell immunoglobulin and mucin receptor (TIM) families are potential alternative receptors of LASV infection. Therefore, the relative contributions of candidate receptors to LASV entry into a particular human cell type are a complex function of receptor expression and functional DG availability. Here, we describe the role of two receptor tyrosine kinases (RTKs), Axl and hepatocyte growth factor receptor (HGFR), in the presence and absence of glycosylated DG for LASV entry. We found that both RTKs participated in the macropinocytosis-related LASV entry and, regardless of the presence or absence of functional DG, their inhibition resulted in a significant antiviral effect.

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