Research Spotlight: Upconversion nanoparticles for potential cancer theranostics

2011 ◽  
Vol 2 (10) ◽  
pp. 1235-1239 ◽  
Author(s):  
Chao Wang ◽  
Liang Cheng ◽  
Zhuang Liu
Keyword(s):  
Upconversion Nanoparticles ◽  
Cancer Theranostics ◽  
Potential Cancer

scholarly journals Gd-Doped Superparamagnetic Magnetite Nanoparticles for Potential Cancer Theranostics

2017 ◽  
Author(s):  
Maheshika Palihawadana-Arachchige ◽  
Vaman M. Naik ◽  
Prem P. Vaishnava ◽  
Bhanu P. Jena ◽  
Ratna Naik
Keyword(s):  
Magnetite Nanoparticles ◽  
Cancer Theranostics ◽  
Potential Cancer

scholarly journals Encapsulation of Upconversion Nanoparticles in Periodic Mesoporous Organosilicas

Molecules ◽  
2019 ◽  
Vol 24 (22) ◽  
pp. 4054 ◽  
Author(s):  
Saher Rahmani ◽  
Chiara Mauriello Jimenez ◽  
Dina Aggad ◽  
Daniel González-Mancebo ◽  
Manuel Ocaña ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Near Infrared ◽  
Sol Gel ◽  
Upconversion Nanoparticles ◽  
X Ray ◽  
Mesoporous Organosilica ◽  
The Matrix ◽  
X Ray Computed ◽  
Mesoporous Organosilicas ◽  
Cancer Theranostics

(1) Background: Nanomedicine has recently emerged as a promising field, particularly for cancer theranostics. In this context, nanoparticles designed for imaging and therapeutic applications are of interest. We, therefore, studied the encapsulation of upconverting nanoparticles in mesoporous organosilica nanoparticles. Indeed, mesoporous organosilica nanoparticles have been shown to be very efficient for drug delivery, and upconverting nanoparticles are interesting for near-infrared and X-ray computed tomography imaging, depending on the matrix used. (2) Methods: Two different upconverting-based nanoparticles were synthesized with Yb3+-Er3+ as the upconverting system and NaYF4 or BaLuF5 as the matrix. The encapsulation of these nanoparticles was studied through the sol-gel procedure with bis(triethoxysilyl)ethylene and bis(triethoxysilyl)ethane in the presence of CTAB. (3) Results: with bis(triethoxysilyl)ethylene, BaLuF5: Yb3+-Er3+, nanoparticles were not encapsulated, but anchored on the surface of the obtained mesoporous nanorods BaLuF5: Yb3+-Er3+@Ethylene. With bis(triethoxysilyl)ethane, BaLuF5: Yb3+-Er3+ and NaYF4: Yb3+-Er3+nanoparticles were encapsulated in the mesoporous cubic structure leading to BaLuF5: Yb3+-Er3+@Ethane and NaYF4: Yb3+-Er3+@Ethane, respectively. (4) Conclusions: upconversion nanoparticles were located on the surface of mesoporous nanorods obtained by hydrolysis polycondensation of bis(triethoxysilyl)ethylene, whereas encapsulation occurred with bis(triethoxysilyl)ethane. The later nanoparticles NaYF4: Yb3+-Er3+@Ethane or BaLuF5: Yb3+-Er3+@Ethane were promising for applications with cancer cell imaging or X-ray-computed tomography respectively.

Upconversion nanocomposites for photo-based cancer theranostics

2016 ◽  
Vol 4 (32) ◽  
pp. 5331-5348 ◽  
Author(s):  
Shuailiang Wang ◽  
Anyao Bi ◽  
Wenbin Zeng ◽  
Zhen Cheng
Keyword(s):  
Penetration Depth ◽  
High Energy ◽  
Upconversion Nanoparticles ◽  
Tissue Penetration ◽  
Excitation Light ◽  
Long Wavelength ◽  
Photochemical Properties ◽  
Cancer Theranostics ◽  
Significant Attention

Upconversion nanoparticles (UCNPs) are able to convert long wavelength excitation light into high energy ultraviolet (UV) or visible emissions, and they have attracted significant attention because of their distinct photochemical properties including sharp emission bands, low autofluorescence, high tissue penetration depth and minimal photodamage to tissues.

Construction of a near-infrared responsive upconversion nanoplatform against hypoxic tumors via NO-enhanced photodynamic therapy

Nanoscale ◽  
2020 ◽  
Vol 12 (14) ◽  
pp. 7875-7887 ◽  
Author(s):  
Ying Lan ◽  
Xiaohui Zhu ◽  
Ming Tang ◽  
Yihan Wu ◽  
Jing Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
Upconversion Nanoparticles

A near-infrared (NIR) activated theranostic nanoplatform based on upconversion nanoparticles (UCNPs) is developed in order to overcome the hypoxia-associated resistance in photodynamic therapy by photo-release of NO upon NIR illumination.

Honaucin A, mechanism of action and role as a potential cancer prevention agent

Planta Medica ◽  
2015 ◽  
Vol 81 (11) ◽  
Author(s):  
L Gerwick ◽  
SJ Mascuch ◽  
G Navarro ◽  
P Boudreau ◽  
TM Carland ◽  
...  
Keyword(s):  
Cancer Prevention ◽  
Mechanism Of Action ◽  
Potential Cancer

Nanoscale Functional Biomaterials for Cancer Theranostics

2018 ◽  
Vol 25 (25) ◽  
pp. 2987-3000 ◽  
Author(s):  
Linying Liu ◽  
Xiaoshuang Li ◽  
Lei Chen ◽  
Xin Zhang
Keyword(s):  
Brain Cancer ◽  
Molecular Level ◽  
Functional Materials ◽  
Therapeutic Agents ◽  
Lower Side ◽  
Drug Delivery Vehicles ◽  
Functional Nanoparticles ◽  
Delivery Vehicles ◽  
Functional Biomaterials ◽  
Cancer Theranostics

Nanomedicine is widely developed in recent years. In nanomedicine system, nanoscale and nanostructured functional materials are used to manipulate the human biology systems at the molecular level for cancer imaging and therapy. New nanostructure based functional materials consist of nanoscale liposomes, spheres, micelles, capsules, emulsion, suspension and phamacosomes. Several functional nanoparticles such as lipidbased and polymer-based materials are demonstrated to be drug delivery vehicles and imaging agents. These materials are biodegradable, biocompatible and have better biodistribution, lower side effect and lower toxicity. In addition, hybrids with these materials coating provide uniquely electrical, optical and magnetic properties. This review discusses the research on the applications of functional materials, especially nanoparticles as imaging contrast agents, cancer therapeutic agents and multi-functional agents and this review focused on the theranostic integration treatments on liver cancer and brain cancer.

Polymer-Graphene Nanoassemblies and their Applications in Cancer Theranostics

2020 ◽  
Vol 20 (11) ◽  
pp. 1340-1351 ◽  
Author(s):  
Ponnurengam M. Sivakumar ◽  
Matin Islami ◽  
Ali Zarrabi ◽  
Arezoo Khosravi ◽  
Shohreh Peimanfard
Keyword(s):  
Mechanical Stability ◽  
Chemical Properties ◽  
The Other ◽  
Hydrophilic Polymer ◽  
Two Dimensional ◽  
Normal Tissues ◽  
Physical Chemical ◽  
Anti Cancer ◽  
Good Biocompatibility ◽  
Cancer Theranostics

Background and objective: Graphene-based nanomaterials have received increasing attention due to their unique physical-chemical properties including two-dimensional planar structure, large surface area, chemical and mechanical stability, superconductivity and good biocompatibility. On the other hand, graphene-based nanomaterials have been explored as theranostics agents, the combination of therapeutics and diagnostics. In recent years, grafting hydrophilic polymer moieties have been introduced as an efficient approach to improve the properties of graphene-based nanomaterials and obtain new nanoassemblies for cancer therapy. Methods and results: This review would illustrate biodistribution, cellular uptake and toxicity of polymergraphene nanoassemblies and summarize part of successes achieved in cancer treatment using such nanoassemblies. Conclusion: The observations showed successful targeting functionality of the polymer-GO conjugations and demonstrated a reduction of the side effects of anti-cancer drugs for normal tissues.

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