Upconversion nanocomposites for photo-based cancer theranostics

2016 ◽  
Vol 4 (32) ◽  
pp. 5331-5348 ◽  
Author(s):  
Shuailiang Wang ◽  
Anyao Bi ◽  
Wenbin Zeng ◽  
Zhen Cheng
Keyword(s):  
Penetration Depth ◽  
High Energy ◽  
Upconversion Nanoparticles ◽  
Tissue Penetration ◽  
Excitation Light ◽  
Long Wavelength ◽  
Photochemical Properties ◽  
Cancer Theranostics ◽  
Significant Attention

Upconversion nanoparticles (UCNPs) are able to convert long wavelength excitation light into high energy ultraviolet (UV) or visible emissions, and they have attracted significant attention because of their distinct photochemical properties including sharp emission bands, low autofluorescence, high tissue penetration depth and minimal photodamage to tissues.

Photochemical Properties of Water-soluble Fluorinated Zinc Phthalocyanines and their Photocytotoxicity Against HeLa Cells

1998 ◽  
Vol 02 (03) ◽  
pp. 219-222 ◽  
Author(s):  
KAORU FUKUSHIMA ◽  
KENJI TABATA ◽  
ICHIRO OKURA
Keyword(s):  
Penetration Depth ◽  
Hela Cells ◽  
Water Soluble ◽  
Absorption Bands ◽  
Long Wavelength ◽  
Zinc Phthalocyanines ◽  
Photodynamic Activity ◽  
Photochemical Properties

Three types of amphiphilic water-soluble fluorinated zinc phthalocyanines are characterized. They have absorption bands at long wavelength, which cause greater penetration depth of a tissue. The uptake and photodynamic activity of the phthalocyanines against HeLa cells were measured, showing that the phthalocyanines exhibited higher photodynamic activities than zinc tetrasulfonated phthalocyanine.

scholarly journals Upconversion Nanoparticles Encapsulated with Amorphous Silica and Their Emission Quenching by FRET: A Nanosensor Excited by NIR for Mercury Detection

Crystals ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 104
Author(s):  
Wei Wu ◽  
Wei Wei ◽  
Dingli Xu ◽  
Yunpeng Liu ◽  
Jin Li ◽  
...  
Keyword(s):  
Composite System ◽  
Near Infrared ◽  
Covalent Bond ◽  
High Energy ◽  
Deep Penetration ◽  
High Signal ◽  
Upconversion Nanoparticles ◽  
Energy Excitation ◽  
Excitation Light ◽  
Emission Quenching

Near-infrared (NIR) region has been considered as a diagnostic window since it avoids sample autofluorescence and light scattering. Upconversion nanoparticles (UCNPs) convert NIR light into high energy excitation light, making them a suitable excitation source for nanoprobes with deep penetration depth and high signal-to-noise ratio. The current work reported a rhodamine-derived probe for the detection of Hg(II). Corresponding absorption and emission responses for Hg(II) and detailed recognizing mechanism were discussed. An absorption titration experiment was performed. It was found that Hg(II) directly bonded with probe with chemical stoichiometry of 1:1, its association constant was calculated as 2.59 × 105 M−1. Such a high value indicated a direct coordination affinity between Hg(II) and this rhodamine-derived probe. Most metal cations exerted no increasing effect on the probe emission or absorption, exhibiting good sensing selectivity of probe towards Hg(II). Upconversion nanoparticles (UCNPs) were firstly encapsulated with silica (SiO2) and then bonded with the probe via a covalent bond. Given a near-infrared (NIR) laser excitation with wavelength of 980 nm, this probe, (E)-2-((3′,6′-bis(diethylamino)-2′,7′-dimethyl-3-oxospiro[isoindoline-1,9′-xanthen]-2-yl)imino)acetaldehyde (denoted as RHO), captured the energy of UCNPs via a FRET (fluorescence resonance energy transfer) path, resulting in the emission quenching of UCNPs. This composite system showed linear sensing behavior towards Hg(II) with high selectivity, which was similar to the case of pure probe. No probe emission, however, was observed from the composite system, which was different from the case of most literature reports. The self-quenching between probe molecules was claimed responsible for the probe emission, which was confirmed by experiment result and analysis. To the best of our knowledge, this is the first demonstration of covalently integrating SiO2-coated UCNPs with a rhodamine-derived probe for Hg(II) sensing.

scholarly journals Nanoscale optical writing through upconversion resonance energy transfer

2021 ◽  
Vol 7 (9) ◽  
pp. eabe2209
Author(s):  
S. Lamon ◽  
Y. Wu ◽  
Q. Zhang ◽  
X. Liu ◽  
M. Gu
Keyword(s):  
Graphene Oxide ◽  
Energy Transfer ◽  
Energy Consumption ◽  
Data Storage ◽  
High Capacity ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
High Energy ◽  
Optical Data ◽  
Upconversion Nanoparticles

Nanoscale optical writing using far-field super-resolution methods provides an unprecedented approach for high-capacity data storage. However, current nanoscale optical writing methods typically rely on photoinitiation and photoinhibition with high beam intensity, high energy consumption, and short device life span. We demonstrate a simple and broadly applicable method based on resonance energy transfer from lanthanide-doped upconversion nanoparticles to graphene oxide for nanoscale optical writing. The transfer of high-energy quanta from upconversion nanoparticles induces a localized chemical reduction in graphene oxide flakes for optical writing, with a lateral feature size of ~50 nm (1/20th of the wavelength) under an inhibition intensity of 11.25 MW cm−2. Upconversion resonance energy transfer may enable next-generation optical data storage with high capacity and low energy consumption, while offering a powerful tool for energy-efficient nanofabrication of flexible electronic devices.

A High-Performance Free-Standing Zn Anode for Flexible Zinc-Ion Batteries

Nanoscale ◽  
2021 ◽  
Author(s):  
Chenxi Gao ◽  
Jiawei Wang ◽  
Yuan Huang ◽  
Zixuan Li ◽  
Jiyan Zhang ◽  
...  
Keyword(s):  
Energy Density ◽  
High Performance ◽  
Low Cost ◽  
High Energy ◽  
Zinc Ion ◽  
High Energy Density ◽  
Free Standing ◽  
Energy Device ◽  
Zn Anode ◽  
Significant Attention

Zinc-ion batteries (ZIBs) have attracted significant attention owing to their high safety, high energy density, and low cost. ZIBs have been studied as a potential energy device for portable and...

scholarly journals Chemiluminescence-initiated and in situ-enhanced photoisomerization for tissue-depth-independent photo-controlled drug release

2019 ◽  
Vol 10 (5) ◽  
pp. 1401-1409 ◽  
Author(s):  
Yufu Tang ◽  
Xiaomei Lu ◽  
Chao Yin ◽  
Hui Zhao ◽  
Wenbo Hu ◽  
...  
Keyword(s):  
Drug Release ◽  
Penetration Depth ◽  
Controlled Drug Release ◽  
Tissue Penetration

Tissue-penetration-depth-independent self-luminescence is highly expected to perform photoisomerization-related bioapplications in vivo to overcome the limitation of shallow tissue-penetration from external photoexcitation.

scholarly journals Effect of Irradiation on Tissue Penetration Depth of Doxorubicin after Pressurized Intra-Peritoneal Aerosol Chemotherapy (PIPAC) in a Novel Ex-Vivo Model

2016 ◽  
Vol 7 (8) ◽  
pp. 910-914 ◽  
Author(s):  
Veria Khosrawipour ◽  
Urs Giger-Pabst ◽  
Tanja Khosrawipour ◽  
Yousef Hedayat Pour ◽  
David Diaz-Carballo ◽  
...  
Keyword(s):  
Penetration Depth ◽  
Ex Vivo ◽  
Tissue Penetration ◽  
Ex Vivo Model

Enhanced Ion Transport Behaviors in Composite Polymer Electrolyte: the Case of Looser Chain Folding Structure

2022 ◽  
Author(s):  
Dexuan Pei ◽  
Rui Ma ◽  
Gang Yang ◽  
Yuhang Li ◽  
Can Huang ◽  
...  
Keyword(s):  
Polymer Electrolytes ◽  
High Energy ◽  
High Energy Density ◽  
Composite Polymer Electrolyte ◽  
Composite Polymer ◽  
Composite Polymer Electrolytes ◽  
Solid State Batteries ◽  
Folding Structure ◽  
All Solid State Batteries ◽  
Significant Attention

All-solid-state batteries based on composite polymer electrolytes (CPEs) have drawn significant attention due to their high energy density, security and flexibility. Usually, the improvement of electrochemical performance of CPEs is...

Yb,Nd,Er-doped upconversion nanoparticles: 980 nm versus 808 nm excitation

Nanoscale ◽  
2019 ◽  
Vol 11 (28) ◽  
pp. 13440-13449 ◽  
Author(s):  
Lisa M. Wiesholler ◽  
Florian Frenzel ◽  
Bettina Grauel ◽  
Christian Würth ◽  
Ute Resch-Genger ◽  
...  
Keyword(s):  
Penetration Depth ◽  
Excitation Power ◽  
Upconversion Nanoparticles ◽  
Er Doped

A set of similarly sized (Yb3+, Nd3+, Er3+)-doped upconversion nanoparticles of different architecture were spectroscopically examined in water at broadly varied excitation power at 980 nm & 808 nm to study the sensitizer dependent penetration-depth.

Near-infrared light-controlled circularly polarized luminescence of self-organized emissive helical superstructures assisted by upconversion nanoparticles

2020 ◽  
Vol 56 (88) ◽  
pp. 13649-13652 ◽  
Author(s):  
Ao Juan ◽  
Hao Sun ◽  
Jinghui Qiao ◽  
Jinbao Guo
Keyword(s):  
Near Infrared ◽  
Infrared Light ◽  
Upconversion Nanoparticles ◽  
Near Infrared Light ◽  
Excitation Light ◽  
Circularly Polarized ◽  
Self Organized ◽  
Circularly Polarized Luminescence ◽  
Polarized Luminescence ◽  
First Time

The reversible switching of circularly polarized luminescence in a self-organized emissive helical superstructure using 980 nm NIR excitation light with different power intensities is reported for the first time.

BIOPHYSICAL SIMULATION TOOL PARTRAC: MODELLING PROTON BEAMS AT THERAPY-RELEVANT ENERGIES

2019 ◽  
Vol 186 (2-3) ◽  
pp. 172-175 ◽  
Author(s):  
Werner Friedland ◽  
Pavel Kundrát ◽  
Janine Becker ◽  
Markus Eidemüller
Keyword(s):  
Dna Damage ◽  
Penetration Depth ◽  
Radiation Effects ◽  
Bragg Peak ◽  
High Energy ◽  
Simulation Tool ◽  
Radiation Physics ◽  
Proton Beams ◽  
Biological Effectiveness ◽  
Penetration Depths

ABSTRACT The biophysical simulation tool PARTRAC has been primarily developed to model radiation physics, chemistry and biology on nanometre to micrometre scales. However, the tool can be applied in simulating radiation effects in an event-by-event manner over macroscopic volumes as well. Benchmark simulations are reported showing that PARTRAC does reproduce the macroscopic Bragg peaks of proton beams, although the penetration depths are underestimated by a few per cent for high-energy beams. PARTRAC also quantifies the increase in DNA damage and its complexity along the beam penetration depth. Enhanced biological effectiveness is predicted in particular within distal Bragg peak parts of therapeutic proton beams.

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