scholarly journals The effect of lipoic acid in the prevention of myocardial infarction in diabetic rats

2018 ◽  
Vol 119 (10) ◽  
pp. 664-669 ◽  
Author(s):  
E. Ozgun ◽  
G. Sayilan Ozgun ◽  
U. Usta ◽  
S. Eskiocak ◽  
N. Sut ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Lipoic Acid ◽  
Diabetic Rats

Serum levels of insulin and leptin in lipoic acid- treated and nontreated experimentally diabetic rats

2008 ◽  
Vol 18 (1) ◽  
pp. 87-95
Author(s):  
M. A. Kandeil ◽  
K. A. Amin ◽  
K. M. A. Hassanin ◽  
K. M. Ali ◽  
Eman T. Mohammed
Keyword(s):  
Lipoic Acid ◽  
Serum Levels ◽  
Diabetic Rats

scholarly journals Sodium–glucose co‐transporter 2 inhibition with empagliflozin improves cardiac function in non‐diabetic rats with left ventricular dysfunction after myocardial infarction

2019 ◽  
Vol 21 (7) ◽  
pp. 862-873 ◽  
Author(s):  
Salva R. Yurista ◽  
Herman H.W. Silljé ◽  
Silke U. Oberdorf‐Maass ◽  
Elisabeth‐Maria Schouten ◽  
Mario G. Pavez Giani ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Cardiac Function ◽  
Left Ventricular Dysfunction ◽  
Ventricular Dysfunction ◽  
Diabetic Rats ◽  
Left Ventricular

Long-Term Alpha-Lipoic Acid (ALA) Antioxidant Therapy Reduces Damage in the Cardiovascular System of Streptozotocin-Induced Diabetic Rats

2021 ◽  
pp. 1-15
Author(s):  
Cristiane Simões Coelho Britto Ramos ◽  
Vivian Alves Pereira da Silva ◽  
Lanna Beatriz Neves Silva Corrêa ◽  
Renato de Souza Abboud ◽  
Gilson Teles Boaventura ◽  
...  
Keyword(s):  
Cardiovascular System ◽  
Lipoic Acid ◽  
Diabetic Rats ◽  
Antioxidant Therapy ◽  
Alpha Lipoic Acid

scholarly journals Effect of alpha-lipoic acid on antioxidant gene expression and kidney injury in alloxan-induced diabetic rats

2018 ◽  
Vol 8 (1) ◽  
pp. 6-6 ◽  
Author(s):  
Parisa Jamor ◽  
Hassan Ahmadvand ◽  
Hesam Ashoory ◽  
Esmaeel Babaeenezhad
Keyword(s):  
Gene Expression ◽  
Lipoic Acid ◽  
Kidney Injury ◽  
Diabetic Rats ◽  
Pcr Analysis ◽  
Control Group ◽  
Diabetic Patients ◽  
Alpha Lipoic Acid ◽  
The Impact ◽  
Gpx Activity

Background: Myeloperoxidase (MPO) is involved in the initiation, progression, and complications of atherosclerosis in diabetic patients. Objectives: In the current study, the impact of alpha-lipoic acid (LA), a natural antioxidant and a cofactor in the enzyme complexes on MPO, catalase (CAT) and glutathione peroxidase (GPx) activity, glutathione (GSH) and malondialdehyde (MDA) level, histopathology of kidney and expression of antioxidant enzymes, superoxide dismutase (SOD), GPx and CAT which are involved in the detoxification of reactive oxygen species (ROS), was evaluated in alloxan-induced diabetic rats. Materials and Methods: In this study, 30 male Rattus norvegicus rats randomly divided into three groups; control (C), non-treated diabetic (NTD), and LA-treated diabetics (LATD) was induced by alloxan monohydrate (100mg/kg; subcutaneous [SC]). Then treatment was performed with alphaLA (100 mg/kg intraperitoneal (i.p) daily to 6 weeks). Blood sample of animals collected to measure levels of MPO, CAT and GPx activity GSH and MDA. Kidney paraffin sections were prepared to estimate histological studies and to measure quantitative gene expression SOD, GPX and CAT in kidney. Results: Induction of diabetes led to a significant increase in MPO and MDA, reduced GSH level and GPx and CAT activities (P < 0.05). However, treatment with alpha-LA led to a significant elevation in GPx, CAT and GSH levels with a reduction in MPO activities and MDA levels (P < 0.05). Furthermore, the real-time reverse transcriptase-polymerase chain reaction (RT-PCR) analysis results showed increased expressions of GPx, CAT and SOD enzyme in the treatment group compared with the diabetic control group. Histopathological lesions such as increased glomerular volume and lymphocyte infiltration were attenuated in the alpha-LA treated group. Conclusions: Our findings indicated that alpha-LA supplementation is effective in preventing complications induced by oxidative stress and atherosclerosis in diabetic rats.

The Effect of Alpha-Lipoic Acid on the Protection of Epidermal Nerve Fibers and Microcapillaries in the Streptozotocin-Induced Diabetic Rats

2007 ◽  
Vol 31 (6) ◽  
pp. 488
Author(s):  
Ming Han Piao ◽  
Heung Yong Jin ◽  
Sun Kyung Song ◽  
Seun Mi Kang ◽  
So Young Kim ◽  
...  
Keyword(s):  
Lipoic Acid ◽  
Diabetic Rats ◽  
Nerve Fibers ◽  
Alpha Lipoic Acid
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