Lipoic acid and diabetes: Effect of dihydrolipoic acid administration in diabetic rats and rabbits

1984 ◽  
Vol 6 (1) ◽  
pp. 37-46 ◽  
Author(s):  
C. V. Natraj ◽  
V. M. Gandhi ◽  
K. K. G. Menon
Keyword(s):  
Lipoic Acid ◽  
Diabetic Rats ◽  
Dihydrolipoic Acid ◽  
Acid Administration

scholarly journals Effect of Fidarestat andα-Lipoic Acid on Diabetes-Induced Epineurial Arteriole Vascular Dysfunction

2004 ◽  
Vol 5 (2) ◽  
pp. 123-135 ◽  
Author(s):  
M. A. Yorek ◽  
L. J. Coppey ◽  
J. S. Gellett ◽  
E. P. Davidson ◽  
D. D. Lund
Keyword(s):  
Body Weight ◽  
Combination Therapy ◽  
Lipoic Acid ◽  
Vascular Dysfunction ◽  
Motor Nerve ◽  
Diabetic Rats ◽  
Motor Nerve Conduction Velocity ◽  
Dihydrolipoic Acid ◽  
Higher Doses ◽  
Neural Dysfunction

In the present study, the authors examined whether treating streptozotocin-induced diabetic rats with the combination ofα-lipoic acid and fidarestat, an aldose reductase inhibitor, can promote the formation of dihydrolipoic acid in diabetic animals and thereby enhance the efficacy ofα-lipoic acid as monotherapy toward preventing diabetic vascular and neural dysfunction.Treating diabetic rats with the combination of 0.25%α-lipoic acid (in the diet) and fidarestat (3 mg/kg body weight) prevented the diabetesinduced slowing of motor nerve conduction velocity and endoneurial blood flow. This therapy also significantly improved acetylcholine-mediated vasodilation in epineurial arterioles of the sciatic nerve compared to nontreated diabetic rats. Treating diabetic rats with 0.25%α-lipoic acid and fidarestat (3 mg/kg body weight) was equally or more effective in preventing vascular and neural dysfunction than was monotherapy of diabetic rats with higher doses ofα-lipoic acid or fidarestat. Treating diabetic rats with the combination of 0.25%α-lipoic acid and fidarestat (3 mg/kg body weight) significantly improved several markers of oxidative stress and increased the serum levels of bothα-lipoic acid and dihydrolipoic acid. These studies suggest that combination therapy consisting ofα-lipoic acid and fidarestat may be more efficacious in preventing diabetes-induced vascular and neural dysfunction in peripheral tissue compared to monotherapy, which requires higher doses to be equally effective. The effect of this combination therapy may in part be due to the increased production and/or level of dihydrolipoic acid.

Serum levels of insulin and leptin in lipoic acid- treated and nontreated experimentally diabetic rats

2008 ◽  
Vol 18 (1) ◽  
pp. 87-95
Author(s):  
M. A. Kandeil ◽  
K. A. Amin ◽  
K. M. A. Hassanin ◽  
K. M. Ali ◽  
Eman T. Mohammed
Keyword(s):  
Lipoic Acid ◽  
Serum Levels ◽  
Diabetic Rats

Long-Term Alpha-Lipoic Acid (ALA) Antioxidant Therapy Reduces Damage in the Cardiovascular System of Streptozotocin-Induced Diabetic Rats

2021 ◽  
pp. 1-15
Author(s):  
Cristiane Simões Coelho Britto Ramos ◽  
Vivian Alves Pereira da Silva ◽  
Lanna Beatriz Neves Silva Corrêa ◽  
Renato de Souza Abboud ◽  
Gilson Teles Boaventura ◽  
...  
Keyword(s):  
Cardiovascular System ◽  
Lipoic Acid ◽  
Diabetic Rats ◽  
Antioxidant Therapy ◽  
Alpha Lipoic Acid

scholarly journals Can Lipoic Acid Attenuate Cardiovascular Disturbances Induced by Ethanol and Disulfiram Administration Separately or Jointly in Rats?

2019 ◽  
Vol 2019 ◽  
pp. 1-10
Author(s):  
Anna Bilska-Wilkosz ◽  
Magdalena Kotańska ◽  
Magdalena Górny ◽  
Barbara Filipek ◽  
Małgorzata Iciek
Keyword(s):  
Blood Pressure ◽  
Rat Liver ◽  
Lipoic Acid ◽  
Aldh Activity ◽  
Dihydrolipoic Acid ◽  
Treatment Groups ◽  
Intracellular Compartments ◽  
Electrocardiogram Ecg ◽  
First Time ◽  
All Treatment

The exogenous lipoic acid (LA) is successfully used as a drug in the treatment of many diseases. It is assumed that after administration, LA is transported to the intracellular compartments and reduced to dihydrolipoic acid (DHLA) which is catalyzed by NAD(P)H-dependent enzymes. The purpose of this study was to investigate whether LA can attenuate cardiovascular disturbances induced by ethanol (EtOH) and disulfiram (DSF) administration separately or jointly in rats. For this purpose, we measured systolic and diastolic blood pressure, recorded electrocardiogram (ECG), and estimated mortality of rats. We also studied the activity of aldehyde dehydrogenase (ALDH) in the rat liver. It was shown for the first time that LA partially attenuated the cardiac arrhythmia (extrasystoles and atrioventricular blocks) induced by EtOH and reduced the EtOH-induced mortality of animals, which suggests that LA may have a potential for use in cardiac disturbance in conditions of acute EtOH intoxication. The administration of EtOH, LA, and DSF separately or jointly affected the ALDH activity in the rat liver since a significant decrease in the activity of the enzyme was observed in all treatment groups. The results indicating that LA is an inhibitor of ALDH activity are very surprising.

scholarly journals The effect of lipoic acid in the prevention of myocardial infarction in diabetic rats

2018 ◽  
Vol 119 (10) ◽  
pp. 664-669 ◽  
Author(s):  
E. Ozgun ◽  
G. Sayilan Ozgun ◽  
U. Usta ◽  
S. Eskiocak ◽  
N. Sut ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Lipoic Acid ◽  
Diabetic Rats

scholarly journals Effect of alpha-lipoic acid on antioxidant gene expression and kidney injury in alloxan-induced diabetic rats

2018 ◽  
Vol 8 (1) ◽  
pp. 6-6 ◽  
Author(s):  
Parisa Jamor ◽  
Hassan Ahmadvand ◽  
Hesam Ashoory ◽  
Esmaeel Babaeenezhad
Keyword(s):  
Gene Expression ◽  
Lipoic Acid ◽  
Kidney Injury ◽  
Diabetic Rats ◽  
Pcr Analysis ◽  
Control Group ◽  
Diabetic Patients ◽  
Alpha Lipoic Acid ◽  
The Impact ◽  
Gpx Activity

Background: Myeloperoxidase (MPO) is involved in the initiation, progression, and complications of atherosclerosis in diabetic patients. Objectives: In the current study, the impact of alpha-lipoic acid (LA), a natural antioxidant and a cofactor in the enzyme complexes on MPO, catalase (CAT) and glutathione peroxidase (GPx) activity, glutathione (GSH) and malondialdehyde (MDA) level, histopathology of kidney and expression of antioxidant enzymes, superoxide dismutase (SOD), GPx and CAT which are involved in the detoxification of reactive oxygen species (ROS), was evaluated in alloxan-induced diabetic rats. Materials and Methods: In this study, 30 male Rattus norvegicus rats randomly divided into three groups; control (C), non-treated diabetic (NTD), and LA-treated diabetics (LATD) was induced by alloxan monohydrate (100mg/kg; subcutaneous [SC]). Then treatment was performed with alphaLA (100 mg/kg intraperitoneal (i.p) daily to 6 weeks). Blood sample of animals collected to measure levels of MPO, CAT and GPx activity GSH and MDA. Kidney paraffin sections were prepared to estimate histological studies and to measure quantitative gene expression SOD, GPX and CAT in kidney. Results: Induction of diabetes led to a significant increase in MPO and MDA, reduced GSH level and GPx and CAT activities (P < 0.05). However, treatment with alpha-LA led to a significant elevation in GPx, CAT and GSH levels with a reduction in MPO activities and MDA levels (P < 0.05). Furthermore, the real-time reverse transcriptase-polymerase chain reaction (RT-PCR) analysis results showed increased expressions of GPx, CAT and SOD enzyme in the treatment group compared with the diabetic control group. Histopathological lesions such as increased glomerular volume and lymphocyte infiltration were attenuated in the alpha-LA treated group. Conclusions: Our findings indicated that alpha-LA supplementation is effective in preventing complications induced by oxidative stress and atherosclerosis in diabetic rats.

The Effect of Alpha-Lipoic Acid on the Protection of Epidermal Nerve Fibers and Microcapillaries in the Streptozotocin-Induced Diabetic Rats

2007 ◽  
Vol 31 (6) ◽  
pp. 488
Author(s):  
Ming Han Piao ◽  
Heung Yong Jin ◽  
Sun Kyung Song ◽  
Seun Mi Kang ◽  
So Young Kim ◽  
...  
Keyword(s):  
Lipoic Acid ◽  
Diabetic Rats ◽  
Nerve Fibers ◽  
Alpha Lipoic Acid
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