Response of serum concentrations of folates to dietary supplements of folic acid given to ewes during gestation

1999 ◽  
Vol 79 (3) ◽  
pp. 387-389 ◽  
Author(s):  
C. L. Girard ◽  
F. Castonguay ◽  
J. J. Matte
Keyword(s):  
Folic Acid ◽  
Key Words ◽  
Dietary Supplements ◽  
Vitamin B ◽  
Serum Concentrations

Serum folates were determined during the 24 h following the ingestion of 0, 130, 260 or 520 mg of folic acid at 12, 61 and 131 d of gestation in 38 ewes. The response of serum folates increased with the dose ingested (P < 0.0001) but decreased as gestation progressed (P < 0.005). Key words: Ewe, dietary supplements, folic acid, vitamin B12

Changes in serum concentrations of folates, pyridoxal, pyridoxal-5-phosphate and vitamin B12 during lactation of dairy cows fed dietary supplements of folic acid

1999 ◽  
Vol 79 (1) ◽  
pp. 107-114 ◽  
Author(s):  
C. L. Girard ◽  
J. J. Matte
Keyword(s):  
Folic Acid ◽  
Dairy Cows ◽  
Dietary Supplements ◽  
Dairy Cow ◽  
Vitamin B ◽  
Early Lactation ◽  
Serum Concentrations ◽  
Ruminal Microorganisms ◽  
Time Parity ◽  
B Complex Vitamins

The present experiment was undertaken to determine the effects of dietary supplements of folic acid (FA) administered from 4 wk prepartum to 305 d of lactation on serum concentrations of folates, vitamin B12, pyridoxal-5-phosphate (P-5-P) and pyridoxal. In addition, concentrations of blood hemoglobin and packed cell volume (PCV) were determined. Sixty-three Holstein cows were assigned to 22 incomplete blocks according to lactation number, milk production and body weight (BW). Within each block, cows received 0, 2 and 4 mg FA d−1 kg−1 BW. Dietary supplements of FA increased serum concentrations of folates (time × FA, P = 0.0001); the highest concentrations were observed during the first two months of lactation in cows fed supplementary FA. The lowest serum concentrations of vitamin B12 were also observed during the first two months of lactation, and the concentrations were lower in primiparous than in multiparous cows (time × parity, P = 0.03). Serum concentrations of P-5-P and pyridoxal were not affected by the dietary supplements of FA (P > 0.1). In multiparous cows, dietary supplements of FA had no effect on changes of hemoglobin and PCV during the lactation (time × FA, P > 0.13). In primiparous cows, PCV and hemoglobin were lower in control cows at parturition whereas by 24 wk of lactation, they were higher in cows fed the highest amount of FA. The lowest values of hemoglobin and PCV were observed during the first two months of lactation. These results give an indication that supply of B-complex vitamins by ruminal microorganisms could be suboptimal for high-producing dairy cows, for example, in early lactation when fed a diet with a high proportion of concentrates. More research is needed to determine the metabolic consequences of these variations. Key words: Dairy cow, vitamin B6, vitamin B12, folic acid, lactation

scholarly journals Serum homocysteine and folate concentrations among a US cohort of adolescents before and after folic acid fortification

2012 ◽  
Vol 15 (10) ◽  
pp. 1818-1826 ◽  
Author(s):  
Daniel A Enquobahrie ◽  
Henry A Feldman ◽  
Deanna H Hoelscher ◽  
Lyn M Steffen ◽  
Larry S Webber ◽  
...  
Keyword(s):  
Folic Acid ◽  
Cardiovascular Health ◽  
Serum Folate ◽  
Vitamin B ◽  
Serum Concentrations ◽  
Folic Acid Fortification ◽  
Serum Homocysteine ◽  
Cereal Grain ◽  
Before And After ◽  
Average Serum

AbstractObjectiveWe assessed serum homocysteine (tHcy) and folate concentrations among US adolescents before and after fortification of cereal-grain products with folic acid, and associations with demographic, behavioural and physiological factors.DesignObservational study conducted among participants of a randomized trial.SettingThe Child and Adolescent Trial for Cardiovascular Health (CATCH) study.SubjectsAdolescents (n2445) in grades 8 (pre-fortification, mean age 14 years) and 12 (post-fortification, mean age 18 years).ResultsAverage serum concentrations of tHcy, folate and vitamin B6increased by 17 %, 16 % and 14 %, respectively, while serum concentrations of vitamin B12decreased by 11 % post-fortification. Folic acid fortification provided, on average, an additional intake of 118 μg folate/d. Male sex (P< 0·0001) and white race (P= 0·0008) were associated with significantly greater increases in tHcy concentration, while increases in BMI (P= 0·006) and serum folate concentration (P< 0·0001) were associated with significant decreases in tHcy concentration. Female sex (P< 0·0001), non-smoking (P< 0·0001), use of multivitamins (P< 0·0001) and higher dietary intake of folate (P= 0·001) were associated with significantly greater increases in serum folate concentrations. From grade 8 to grade 12, the upward age trend in serum tHcy concentration was uninterrupted in its course (P> 0·50); whereas serum folic acid concentration showed a downward trend that incurred a discrete jump upward (17 % higher;P< 0·0001) with fortification. These trends differed significantly for malesv. females (P< 0·001 for interaction).ConclusionsFortification had a significant impact on improving folate status but not serum tHcy concentrations among US adolescents.

BLOOD SERUM CONCENTRATIONS OF FOLATES AND VITAMIN B12 DURING GROWTH PERIOD OF WHITE VEAL CALVES

1988 ◽  
Vol 68 (2) ◽  
pp. 455-460 ◽  
Author(s):  
C. L. GIRARD ◽  
J. J. MATTE
Keyword(s):  
Vitamin B12 ◽  
Blood Serum ◽  
Key Words ◽  
Growth Period ◽  
Age Effect ◽  
Vitamin B ◽  
Serum Concentrations ◽  
Lower Serum ◽  
Veal Calves ◽  
Milk Replacers

Variations of hemoglobin, hematocrit, folates and vitamin B12 concentrations in blood serum were studied during the rearing period of 62 rapidly growing (1.6 kg d−1) white veal calves. The animals were fed exclusively with milk replacers during the 110 d rearing period. Hemoglobin and hematocrit decreased linearly with time (P < 0.0001). There was an age effect (P < 0.0001) on serum concentrations of vitamin B12 and folates during the rearing period. The serum concentrations of vitamin B12 increased during the first 3 wk from 214.8 pg mL−1 to 422.6 pg mL−1 and then were stable until the 13th week of the rearing period. Serum concentrations of folates decreased during the 3 wk from 11.3 ng mL−1 to 5.1 ng mL−1 and then increased to reach a stable concentration of about 14 ng mL−1 from 6 wk to the end of the rearing period. Males had significantly lower serum folates concentrations than females (P < 0.0001) but their serum profiles during the rearing period were similar. Further studies will be necessary to elucidate the consequences of a decrease in serum folates during the starting period on the growth performance of white veal calves. Key words: White veal calves, blood serum folates, vitamin B12

scholarly journals Retention, stability, iron bioavailability and sensory evaluation of extruded rice fortified with iron, folic acid and vitamin B 12

2020 ◽  
Vol 16 (S3) ◽  
Author(s):  
Yvette Wilda Jyrwa ◽  
Ravindranadh Palika ◽  
Swetha Boddula ◽  
Naveen Kumar Boiroju ◽  
Radhika Madhari ◽  
...  
Keyword(s):  
Folic Acid ◽  
Sensory Evaluation ◽  
Iron Bioavailability ◽  
Vitamin B ◽  
Vitamin B 12 ◽  
Iron Folic Acid

Comparison of supplemental cobalt form on fibre digestion and cobalamin concentrations in cattle

2017 ◽  
Vol 155 (5) ◽  
pp. 832-838 ◽  
Author(s):  
R. C. WATERMAN ◽  
W. L. KELLY ◽  
C. K. LARSON ◽  
M. K. PETERSEN
Keyword(s):  
Crude Protein ◽  
Dry Matter ◽  
National Research Council ◽  
Residual Effect ◽  
Vitamin B ◽  
Serum Concentrations ◽  
Forage Digestibility ◽  
Randomized Experimental Design ◽  
To Receive

SUMMARYCobalt (Co) is essential for rumen microbial metabolism to synthesize methane, acetate and methionine. It also serves as a structural component of vitamin B12(cobalamin), which functions as a coenzyme in energy metabolism. A study was conducted to determine if Co form (carbonatev. glucoheptonate) supplemented above the National Research Council requirements would improve digestibility of a low-quality forage diet and change serum cobalamin concentrations. Nineteen ruminally cannulated cows (577 ± 13 kg) were fed individually in a completely randomized experimental design. Cows were fed a grass hay diet that contained (79·2 g/kg crude protein, 565 g/kg total digestible nutrients, 633·2 g/kg neutral detergent fibre (NDF), 874·2 g/kg dry matter) at a rate of 0·02% of body weight on a as fed basis for a 62-day study, which consisted of three periods; acclimation (AC), treatment (TR) and residual (RE). Measurements taken in the AC period were used as covariates for analysis in the TR and RE periods. Cows were stratified by age (5 ± 0·4 years) and lactational history, and assigned to receive 12·5 mg supplemental Co in one of two forms: (1) 27·2 mg of Co carbonate (CC,n= 11 cows) or (2) 50 mg of Co glucoheptonate (CGH,n= 8 cows). Supplement was administered daily via a gelatin capsule placed directly into the rumen 2 h after feeding. During the last 96 h of each period, forage digestibility was measured using anin situnylon bag technique. Blood samples were collected 4 and 6 h following feeding, and 24 h before the end of each period. A treatment × period interaction was detected forin situorganic matter (OM) disappearance at 96 h; (TR period: 684 and 708 ± 81 g/kg; RE period: 676 and 668 ± 75 g/kg, for CC and CGH, respectively). Once inclusion of Co in the CGH group was removed, OM disappearance was reduced by 4·01% compared with 0·82% in the CC cows. The NDF disappearance (OM basis) was less for the TR compared with the RE at 48 h (629 and 652 ± 39 g/kg, respectively). However, by 96 h NDF disappearance was greater for TR than the RE (704 and 689 ± 44 g/kg; respectively). No differences were detected for cobalamin serum concentrations or rate of fibre fermentation. The outcomes of the current research signify that there may be a slight residual effect of Co supplementation on fermentation; there was also an indication that Co source may enhance the overall extent of fermentation.

EXCRETION OF 4(5)-AMINO-5(4)-IMIDAZOLECARBOXAMIDE AND FORMIMINO-L-GLUTAMIC ACID IN FOLIC ACID AND VITAMIN B12 DEFICIENT RATS

1965 ◽  
Vol 43 (8) ◽  
pp. 1367-1374 ◽  
Author(s):  
P. L. McGeer ◽  
N. P. Sen ◽  
D. A. Grant
Keyword(s):  
Folic Acid ◽  
Glutamic Acid ◽  
Fold Increase ◽  
Urocanic Acid ◽  
Vitamin B ◽  
Deficient Diet ◽  
Intraperitoneal Dose ◽  
Group A ◽  
Acid Load ◽  
Deficient Group

The excretion of 4(5)-amino-5(4)-imidazolecarboxamide (AIC) in the urines of normal rats, rats raised on a folic acid deficient diet, and rats raised on a vitamin B12 deficient diet was measured. The AIC excretion was elevated 3-fold above normal in the B12 deficient group and 1.5-fold above normal in the folic acid deficient group.No evidence could be found that the raised AIC excretion was associated with a block in the conversion of AIC to purines. The recovery of radioactive AIC in the urine after an intraperitoneal dose of 2 μmoles AIC per kg was not increased over normal in any of the deficient groups, and was significantly less than normal in the B12-deficient group. Most of the urinary radioactivity in all groups was in allantoin, uric acid, and purines.When a load of 220 μmoles of AIC per kg was administered there was no difference between the vitamin B12 deficient and the normal groups in AIC recovery in the urine. When a load of 220 μmoles of urocanic acid per kg was administered, however, the B12-deficient group had an 18-fold increase over normal in Figlu excretion, and the folic acid deficient group a 17-fold increase. Thus, a substantial block in formimino-L-glutamic acid (Figlu) metabolism, but not in AIC metabolism, existed in the vitamin-deficient groups.Feeding a B12-deficient group a 2% methionine supplement reduced the Figlu excretion after a urocanic acid load to less than half that observed in B12-deficient groups without methionine supplementation, but had no influence on the AIC excretion.

Vitamin B12 deficiency is the dominant nutritional cause of hyperhomocysteinemia in a folic acid-fortified population

2005 ◽  
Vol 43 (10) ◽  
Author(s):  
Ralph Green ◽  
Joshua W. Miller
Keyword(s):  
United States ◽  
Folic Acid ◽  
Vitamin B12 Deficiency ◽  
The United States ◽  
Community Dwelling ◽  
Vitamin B ◽  
Prevalence Rates ◽  
Total Vitamin ◽  
Folic Acid Fortification ◽  
B12 Deficiency

AbstractPrevalence rates for folate deficiency and hyperhomocysteinemia have been markedly reduced following the introduction of folic acid fortification in the United States. We report the prevalence of hyperhomocysteinemia in a population of community-dwelling elderly Latinos in the post-folic acid fortification era. We measured homocysteine, total vitamin B

Nutrient content of liquid milk

1984 ◽  
Vol 51 (1) ◽  
pp. 37-50 ◽  
Author(s):  
K. John Scott ◽  
Dinah R. Bishop ◽  
Alicja Zechalko ◽  
John D. Edwards-Webb ◽  
Patricia A. Jackson ◽  
...  
Keyword(s):  
Folic Acid ◽  
Seasonal Variation ◽  
Pantothenic Acid ◽  
Nutrient Content ◽  
Vitamin B ◽  
Mean Values ◽  
Channel Island ◽  
Vitamin Content ◽  
The Mean ◽  
Β Carotene

SummaryA survey was undertaken to update and extend available information on the vitamin content of pasteurized milk as produced at processing dairies in mainland UK and to investigate regional, seasonal and breed effects. The concentration of total retinol in milk from non-Channel Island (NCI) breeds averaged 61·9 βg/100g in summer and 41·2 βg/100g in winter. Concentrations of β-carotene were 31·5 and 10·5 βg/100g in summer and winter respectively. Concentrations of retinol in milk from Channel Island (CI) breeds were similar, but concentrations of β-carotene were on average 3 times higher. The concentration of vitamin D3 in milk from NCI breeds was 0·033 βg/100g in summer and 0·026 βg/100g in winter. There was no marked seasonal variation in the mean concentration of total vitamin C (14·5 βg/ml). Values for the concentration of B vitamins (βg/ml) were: folic acid 0·060, vitamin B12 0·0042, riboflavin 1·78, nicotinic acid 0·71, pantothenic acid 3·60, biotin 0·020, thiamin 0·46 and vitamin B6 0·61. Seasonal variation in the concentration was most marked for folic acid (c.v. 17·4%) and to a lesser extent for vitamin B12 (c.v. 10·3%). The only breed differences in the B vitamin content were for riboflavin and folic acid, the mean values obtained for milk from CI breeds being respectively 20 and 10 % higher than those from NCI breeds.

Folic acid and vitamin B12 status of vervet monkeys used for nutritional research

1993 ◽  
Vol 27 (1) ◽  
pp. 59-64 ◽  
Author(s):  
F. S. Venter ◽  
H. Cloete ◽  
J. V. Seier ◽  
M. J. Faber ◽  
J. E. Fincham
Keyword(s):  
Folic Acid ◽  
Inverse Relationship ◽  
Atherogenic Diet ◽  
The Other ◽  
Vitamin B ◽  
Plasma Vitamin ◽  
Vervet Monkeys ◽  
Adult Males ◽  
Competitive Protein Binding ◽  
Apparently Healthy

Plasma and red blood cell (RBC) folic acid levels, as well as plasma vitamin B12 levels were determined in Vervet monkeys ( Cercopithecus aethiops). All the vervets were apparently healthy and without symptoms or lesions typical of folic acid and/or vitamin B12 deficiencies. Competitive protein binding radioassays were used to determine folate and vitamin B12 values in animals fed 4 different diets. The B12 levels for all the groups ranged between 866 and 5867 pg/ml and showed an inverse relationship with the FA measurements. The lowest mean RBC folic acid content in a group fed an atherogenic diet for 3 years was 12·8 ng/ml. For the other 3 diets, mean RBC folic acid levels were 90·7, 132·3 and 152·8 ng/ml, respectively. A megadose of 25·6 mg of folic acid per day for 99 days was given to 3 adult males. No obvious toxic effects were observed in these animals although mean RBC folic acid levels increased to 1013 ng/ml.

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