Increased Serum Cu/Zn SOD in Individuals with Bipolar Disorder

2010 ◽  
Vol 3 ◽  
pp. PRI.S5527
Author(s):  
A.J. Russo
Keyword(s):  
Bipolar Disorder ◽  
Superoxide Dismutase ◽  
Serum Concentration ◽  
Serum Levels ◽  
Age And Gender ◽  
And Gender

Aim To assess serum Cu/Zn SOD (Superoxide Dismutase) concentration in individuals with bipolar disorder. Subjects and methods Serum from 20 individuals diagnosed with bipolar disorder and 20 age and gender similar controls were tested for Cu/Zn SOD serum concentration using ELISAs. Results Serum Cu/Zn SOD levels of individuals with bipolar disorder were significantly higher than age and gender matched controls. Discussion These results suggest an association between Cu/Zn SOD serum levels and bipolar disorder.

scholarly journals Increased Serum Cu/Zn SOD in Individuals with Clinical Depression Normalizes after Zinc and Anti-oxidant Therapy

2010 ◽  
Vol 3 ◽  
pp. NMI.S5044 ◽  
Author(s):  
A.J. Russo
Keyword(s):  
Superoxide Dismutase ◽  
Serum Concentration ◽  
Serum Levels ◽  
Clinical Depression ◽  
Healthy Controls ◽  
Age And Gender ◽  
Anti Oxidant ◽  
And Gender

Aim To assess serum Cu/Zn SOD (Superoxide Dismutase) concentration in individuals with clinical depression. Subjects and Methods Serum from 36 individuals diagnosed with clinical depression and 18 healthy controls were tested for Cu/Zn SOD serum concentration using ELISAs. Results Serum Cu/Zn SOD levels of depressed individuals (both with and without secondary anxiety) were significantly higher than age and gender similar controls. We also found that, post anti-oxidant therapy, Cu/Zn SOD levels normalized to the level of normal healthy controls. Discussion These results suggest an association between Cu/Zn SOD serum levels and clinical depression.

scholarly journals Increased Serum Cu/Zn Superoxide Dismutase in Individuals with Anxiety

2010 ◽  
Vol 3 ◽  
pp. PRI.S5180 ◽  
Author(s):  
A.J. Russo
Keyword(s):  
Superoxide Dismutase ◽  
Anxiety Disorder ◽  
Serum Concentration ◽  
Serum Levels ◽  
Age And Gender ◽  
Immunosorbent Assays ◽  
And Gender

The aim of this study was to assess serum Cu/Zn SOD (Superoxide Dismutase) concentration in individuals with anxiety disorder. Serum from 16 individuals diagnosed with anxiety (no secondary depression) and 18 age and gender matched controls were tested for Cu/Zn SOD serum concentration using Enzyme Linked Immunosorbent Assays (ELISAs). Serum Cu/Zn SOD levels of anxiety individuals were significantly higher than age and gender matched controls. These results suggest an association between Cu/Zn SOD serum levels and Anxiety Disorder.

scholarly journals Decreased Serum Hepatocyte Growth Factor (HGF) in Individuals with Bipolar Disorder Normalizes after Zinc and Anti-oxidant Therapy

2010 ◽  
Vol 3 ◽  
pp. NMI.S5528 ◽  
Author(s):  
A.J. Russo
Keyword(s):  
Bipolar Disorder ◽  
Serum Concentration ◽  
Inductively Coupled Plasma ◽  
Serum Levels ◽  
Age And Gender ◽  
Inductively Coupled ◽  
Plasma Mass Spectrometry ◽  
And Gender ◽  
Zinc Levels ◽  
Bipolar Patients

Aim To assess serum HGF concentration in individuals with bipolar disorder and investigate the efficacy of zinc therapy on these levels. Subjects and Methods Serum from 35 individuals diagnosed with bipolar disorder and 19 age and gender similar controls were tested for HGF concentration using ELISAs, and copper and zinc plasma levels using inductively-coupled plasma-mass spectrometry. Results HGF serum levels of individuals with bipolar disorder were significantly lower than age and gender similar controls ( P = 0.0021). HGF serum concentration was significantly lower in Bipolar patients pre-therapy ( P = 0.0009) and HGF levels normalized post-therapy. Zinc levels in these same individuals also normalized ( P = 0.0046) and patient's perceived severity of Bipolar symptoms significantly decreased after therapy ( P = 0.0003). We also found a significant direct correlation between Zinc and HGF serum concentration in the bipolar patients ( P = 0.04). Discussion These results suggest an association between low HGF levels and bipolar disorder and also demonstrate that zinc therapy may be associated with the normalization of HGF levels and decrease in severity of disease.

scholarly journals Neurotrophins, cytokines, oxidative parameters and funcionality in Progressive Muscular Dystrophies

2015 ◽  
Vol 87 (3) ◽  
pp. 1809-1818 ◽  
Author(s):  
CLARISSA M. COMIM ◽  
GISIANE B. MATHIA ◽  
ANDREZA HOEPERS ◽  
LISIANE TUON ◽  
FLÁVIO KAPCZINSKI ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Muscular Dystrophy ◽  
Inflammatory Cytokine ◽  
Serum Levels ◽  
Superoxide Dismutase Activity ◽  
Age And Gender ◽  
Tnf Α ◽  
Cytokine Levels ◽  
And Gender ◽  
Anti Inflammatory Cytokine

We investigated the levels of brain derived-neurotrophic factor (BDNF), cytokines and oxidative parameters in serum and tried to correlate them with the age and functionality of patients with Progressive Muscle Dystrophies (PMD). The patients were separated into six groups (case and controls pared by age and gender), as follows: Duchenne Muscular Dystrophy (DMD); Steinert Myotonic Dystrophy (SMD); and Limb-girdle Muscular Dystrophy type-2A (LGMD2A). DMD patients (±17.9 years old) had a decrease of functionality, an increase in the IL-1β and TNF-α levels and a decrease of IL-10 levels and superoxide dismutase activity in serum. SMD patients (±25.8 years old) had a decrease of BDNF and IL-10 levels and superoxide dismutase activity and an increase of IL-1β levels in serum. LGMD2A patients (±27.7 years old) had an decrease only in serum levels of IL-10. This research showed the first evidence of BDNF involvement in the SMD patients and a possible unbalance between pro-inflammatory and anti-inflammatory cytokine levels, along with decreased superoxide dismutase activity in serum of DMD and SMD patients.

scholarly journals Age- and Gender-Related Differences in LDL-Cholesterol Management in Outpatients with Type 2 Diabetes Mellitus

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Giuseppina Russo ◽  
Basilio Pintaudi ◽  
Carlo Giorda ◽  
Giuseppe Lucisano ◽  
Antonio Nicolucci ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Serum Levels ◽  
Diabetes Duration ◽  
Lipid Lowering ◽  
Age And Gender ◽  
Chd Risk ◽  
And Gender

Background. Dyslipidemia contribute to the excess of coronary heart disease (CHD) risk observed in women with type 2 diabetes (T2DM). Low density lipoprotein-cholesterol (LDL-C) is the major target for CHD prevention, and T2DM women seem to reach LDL-C targets less frequently than men.Aim. To explore age- and gender-related differences in LDL-C management in a large sample of outpatients with T2DM.Results. Overall, 415.294 patients (45.3% women) from 236 diabetes centers in Italy were included. Women were older and more obese, with longer diabetes duration, higher total-cholesterol, LDL-C, and HDL-C serum levels compared to men (P<0.0001). Lipid profile was monitored in ~75% of subjects, women being monitored less frequently than men, irrespective of age. More women did not reach the LDL-C target as compared to men, particularly in the subgroup treated with lipid-lowering medications. The between-genders gap in reaching LDL-C targets increased with age and diabetes duration, favouring men in all groups.Conclusions. LDL-C management is worst in women with T2DM, who are monitored and reach targets less frequently than T2DM men. Similarly to men, they do not receive medications despite high LDL-C. These gender discrepancies increase with age and diabetes duration, exposing older women to higher CHD risk.

Hair Magnesium content and its relation to Serum Magnesium level in children with Idiopathic Epilepsy

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Hamed Mahmoud Shatla ◽  
Mariam Fathy Abdel Maksoud ◽  
Raghda Mohamed Hesham Zaitoun ◽  
Alaa Rabie Abdel Baset Mahmoud
Keyword(s):  
Serum Magnesium ◽  
Serum Levels ◽  
Magnesium Content ◽  
Magnesium Level ◽  
Idiopathic Epilepsy ◽  
Age And Gender ◽  
Control Subjects ◽  
Significant Difference ◽  
And Gender ◽  
Patients With Epilepsy

Abstract Objective To measure the level of hair Mg, as well as its level in serum, in patients with epilepsy and compare them to the levels found in non-epileptic age and gender matched children, and to explore any potential correlation between either serum or hair level of magnesium and seizure characteristics in children with idiopathic epilepsy. Methods An observational cross-sectional study including 50 children with idiopathic epilepsy and 100 non-epileptic age and gender matched control subjects. Cases were subjected to full history taking, examination and measurements of serum and hair levels of magnesium, control subjects only had their serum and hair level of magnesium measured as for the cases. Results The mean serum magnesium was 29.11 ± 13.42 ug/ml for cases and 27.67 ± 7.24 ug/ml for controls and the median hair level of magnesium was 42.22 ug/g with IQR of 25.9 - 56.82 for cases and 38.6 ug/g with IQR of 25.21 - 61.25 for controls. No statistically significant difference was observed between both groups as regards either serum or hair magnesium levels. No statistically significant correlation was observed between either hair or serum levels of magnesium and seizure characteristics though the correlations were nearing statistical significance for the hair magnesium content. Conclusion Hair magnesium level may be better correlated to seizure characteristics and control than serum levels in patients with epilepsy.

scholarly journals Effects of age and gender on the serum levels of clozapine, olanzapine, risperidone, and quetiapine

2017 ◽  
Vol 136 (5) ◽  
pp. 455-464 ◽  
Author(s):  
I. Castberg ◽  
A. A. Westin ◽  
E. Skogvoll ◽  
O. Spigset
Keyword(s):  
Serum Levels ◽  
Age And Gender ◽  
And Gender

scholarly journals Age and sex-related changes in superoxide dismutase activity in bovine tissues

2018 ◽  
Vol 60 (No. 8) ◽  
pp. 367-374 ◽  
Author(s):  
M. Giergiel ◽  
M. Kankofer
Keyword(s):  
Superoxide Dismutase ◽  
Metabolic Rate ◽  
Skeletal Muscles ◽  
Sod Activity ◽  
Age And Gender ◽  
Age Related ◽  
Blotting Technique ◽  
And Gender ◽  
Gender Discrepancies ◽  
Page Electrophoresis

The influence of age, gender, and type of tissue on superoxide dismutase (SOD) activity in bovine organs and tissues was investigated. The investigated material consisted of fragments of tissues and organs (liver, heart, lung, kidney, skeletal muscles, and diaphragm) from healthy cows (n = 15), bulls (n = 15), and female calves (n = 12) collected immediately after slaughter at the slaughterhouse. The total SOD activity was measured in tissue and organ homogenates by spectrophotometric method. PAGE electrophoresis and Western blotting technique with specific anti-SOD antibodies as well as zymography confirmed the presence of enzymatic protein and SOD isoenzymes in examined tissues. The study revealed significant differences in SOD activity between organs and tissues, which might be connected with different metabolic rate. Age-related changes were also observed. SOD activity was twice higher in kidneys, lungs, heart of calves compared to other groups of animals. It was also noticed that SOD activity was higher in younger animals and decreased with ageing among the group of bulls. Gender-related differences were observed in lungs and diaphragm. It was concluded that SOD activity depends on sex steroids, which is reflected in age and gender discrepancies, as well as metabolic rate of tissues.

scholarly journals Serum Soluble CD89-IgA Complexes Are Elevated in IgA Nephropathy without Immunosuppressant History

2020 ◽  
Vol 2020 ◽  
pp. 1-6 ◽  
Author(s):  
Haiting Wu ◽  
Xiaoyan Wang ◽  
Zhe Yang ◽  
Qing Zhao ◽  
Yubing Wen ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Healthy Subjects ◽  
Sandwich Elisa ◽  
Clinical Manifestations ◽  
Serum Levels ◽  
Healthy Individuals ◽  
Oxford Classification ◽  
Age And Gender ◽  
Capture Antibody ◽  
And Gender

Purpose. CD89 (FcαRI), the receptor of IgA, can shed from cells to form complexes with IgA in serum and is supposed to participate in the pathogenesis of IgA nephropathy (IgAN). There are contradictory results on their utility in clinical practice. This study is aimed at investigating whether sCD89-IgA complexes can help in the diagnosis or evaluation of the disease. Methods. A sandwich ELISA was established using anti-CD89 as a capture antibody and HRP-conjugated anti-IgA as a detection antibody. This method was used to measure serum levels of sCD89-IgA complexes in IgAN patients without immunosuppressant history and healthy subjects. Correlations between serum levels of sCD89-IgA complexes and disease severity were analyzed. Results. Serum sCD89-IgA complexes increased with age (P<0.001). IgAN patients had higher sCD89-IgA complex levels compared with age- and gender-matched normal healthy individuals (P<0.001). Serum sCD89-IgAN significantly predicted IgAN diagnosis (AUC = 0.762 (0.640-0.883), P<0.001). But sCD89-IgA complexes did not correlate with baseline clinical manifestations, oxford classification, or renal function deteriorate speed. Conclusions. Serum sCD89-IgA complexes can guide diagnosis of IgAN in patients without immunosuppressant history, but provide limited help in clinicopathologic prediction.

Osteopontin Predicts for Survival and Cystatin C-Based Estimated GFR Predicts for Renal Response to Therapy in Patients with Primary Systemic Amyloidosis

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 2731-2731
Author(s):  
Evangelos Terpos ◽  
Efstathios Kastritis ◽  
Evelina Charitaki ◽  
Michalis Michail ◽  
Georgios Boutsikas ◽  
...  
Keyword(s):  
Cystatin C ◽  
Univariate Analysis ◽  
Serum Levels ◽  
Response To Therapy ◽  
Systemic Amyloidosis ◽  
Cysteine Proteinase Inhibitor ◽  
Age And Gender ◽  
Renal Response ◽  
Heart Involvement ◽  
And Gender

Abstract Primary systemic amyloidosis (AL) is a multisystemic disorder resulting from an underlying plasma cell dyscrasia. Elevated serum N-terminal pro-brain natriuretic peptide (NT-proBNP) is considered as one of the most powerful prognostic markers in AL. Angiogenesis is a crucial step for disease progression in several malignancies, including multiple myeloma (MM). Osteopontin (OPN) is a glycophosphoprotein cytokine, which has significant role in cell adhesion, prevention of apoptosis, invasion, migration and tumor cell growth. OPN also participates in neo-angiogenesis process in malignancies, as in MM. Renal involvement is common in AL, resulting in renal impairment in a significant proportion of patients. Cystatin-C (Cys-C) is a cysteine-proteinase inhibitor, which is considered as a reliable endogenous marker of GFR. Furthermore, our group has shown that Cys-C is an independent prognostic factor in MM. The aim of this study was to evaluate the levels of OPN, Cys-C and angiogenesis cytokines in AL, explore possible correlations with clinical characteristics and known prognostic factors, as NT-proBNP, and compare the results with those of MM. Serum levels of angiopoietin-1 and -2 (Ang-1, Ang-2), VEGF, angiogenin, basic fibroblast growth factor (bFGF) and OPN were evaluated using ELISA methodology (R&D, Minneapolis, MN, USA, for all, except of OPN: IBL GmbH D, Hamburg, Gemany). Serum Cys-C was determined by particle enhanced immunonephelometry (Dade Behring, Liederbach, Germany), while serum NT-proBNP was evaluated using an electrochemiluminescensce immunoassay (Roche Diagnostics GmbH, Mannheim, Germany). Serum samples were collected from 82 previously untreated AL patients (39M/43F), 35 age- and gender-matched healthy controls and 35 newly diagnosed, untreated, MM patients of similar age and gender. The median age of AL patients was 63 years (range: 39–86 years), and the median number of involved organs was 2 (range: 1–4). Heart was involved in 45 (56%) patients, kidney in 61 (76%) and liver in 11 (14%) patients. Serum levels of OPN (&lt;0.01), VEGF (p&lt;0.001), bFGF (&lt;0.001), angiogenin (p&lt;0.001) and Ang-2 (p&lt;0.001) were significantly higher in AL patients than in controls; however Ang-1 levels did not differ between AL patients and controls (p=0.321), thus the ang1/ang2 ratio was lower in AL patients (p=0.036). Compared to MM patients, AL patients had significantly higher VEGF (p&lt;0.001), angiogenin (p&lt;0.001), and Ang-1 (p=0.001) levels but lower levels of Ang-2 (0.001) resulting in a significantly higher Ang-1/2 ratio (p&lt;0.001). OPN levels did not differ between AL and myeloma patients (p=0.169). OPN correlated with NT-proBNP levels in AL (r=0.342, p=0.004). Ang-2 levels were significantly higher in AL patients with heart involvement (p=0.008) resulting in lower Ang-1/2 ratio (p=0.03). Cys-C levels were higher in AL patients compared to both controls and MM patients (p&lt;0.0001). The eGFR estimated with the MDRD equation and 3 different equations that included Cys-C only; Cys-C and age; and Cys-C, creatinine and age (Stevens et al, Am J Kidney Dis2008;51:396–406) were 65, 44, 41 and 45 ml/min/1.73m2, respectively (p&lt;0.001). All eGFR evaluations were associated with the probability of renal response to therapy. However, in multivariate analysis, only the equation that included Cys-C, creatinine and age predicted indepedently for renal response to therapy (HR 8.8, 95% CI 1.2– 67, p=0.033). The median survival of this cohort of patients has not been reached yet; the 24-month survival rate was 66%. In univariate analysis high NT-proBNP levels (p&lt;0.001), heart involvement (p&lt;0.01), ejection fraction &lt;55% (p&lt;0.01), high serum OPN (p=0.01), performance status ≥2 (p=0.011), ≥2 involved organs (p=0.02), no organ response to therapy (p=0.023), urine albumin (&gt;3500 mg/24h; p=0.031), and no hematologic response to therapy (p=0.034) predicted for poor survival. However, NT-proBNP and OPN were both independently associated with survival in a multivariate model. This study suggests that angiogenesis cytokines are increased in AL, even compared to MM. More importantly, high OPN levels predicts for inferior survival, while eGFR based on Cys-C, creatinine and age predicts for renal response to therapy. NTproBNP remains a valuable predictive factor for survival in AL.

Sign in / Sign up

Export Citation Format

Share Document