scholarly journals Increased Serum Cu/Zn SOD in Individuals with Clinical Depression Normalizes after Zinc and Anti-oxidant Therapy

2010 ◽  
Vol 3 ◽  
pp. NMI.S5044 ◽  
Author(s):  
A.J. Russo
Keyword(s):  
Superoxide Dismutase ◽  
Serum Concentration ◽  
Serum Levels ◽  
Clinical Depression ◽  
Healthy Controls ◽  
Age And Gender ◽  
Anti Oxidant ◽  
And Gender

Aim To assess serum Cu/Zn SOD (Superoxide Dismutase) concentration in individuals with clinical depression. Subjects and Methods Serum from 36 individuals diagnosed with clinical depression and 18 healthy controls were tested for Cu/Zn SOD serum concentration using ELISAs. Results Serum Cu/Zn SOD levels of depressed individuals (both with and without secondary anxiety) were significantly higher than age and gender similar controls. We also found that, post anti-oxidant therapy, Cu/Zn SOD levels normalized to the level of normal healthy controls. Discussion These results suggest an association between Cu/Zn SOD serum levels and clinical depression.

scholarly journals Increased Serum Cu/Zn Superoxide Dismutase in Individuals with Anxiety

2010 ◽  
Vol 3 ◽  
pp. PRI.S5180 ◽  
Author(s):  
A.J. Russo
Keyword(s):  
Superoxide Dismutase ◽  
Anxiety Disorder ◽  
Serum Concentration ◽  
Serum Levels ◽  
Age And Gender ◽  
Immunosorbent Assays ◽  
And Gender

The aim of this study was to assess serum Cu/Zn SOD (Superoxide Dismutase) concentration in individuals with anxiety disorder. Serum from 16 individuals diagnosed with anxiety (no secondary depression) and 18 age and gender matched controls were tested for Cu/Zn SOD serum concentration using Enzyme Linked Immunosorbent Assays (ELISAs). Serum Cu/Zn SOD levels of anxiety individuals were significantly higher than age and gender matched controls. These results suggest an association between Cu/Zn SOD serum levels and Anxiety Disorder.

Increased Serum Cu/Zn SOD in Individuals with Bipolar Disorder

2010 ◽  
Vol 3 ◽  
pp. PRI.S5527
Author(s):  
A.J. Russo
Keyword(s):  
Bipolar Disorder ◽  
Superoxide Dismutase ◽  
Serum Concentration ◽  
Serum Levels ◽  
Age And Gender ◽  
And Gender

Aim To assess serum Cu/Zn SOD (Superoxide Dismutase) concentration in individuals with bipolar disorder. Subjects and methods Serum from 20 individuals diagnosed with bipolar disorder and 20 age and gender similar controls were tested for Cu/Zn SOD serum concentration using ELISAs. Results Serum Cu/Zn SOD levels of individuals with bipolar disorder were significantly higher than age and gender matched controls. Discussion These results suggest an association between Cu/Zn SOD serum levels and bipolar disorder.

scholarly journals The Level of Vitamin A and Selenium of Cystic Echinococcosis in Aba and Garze Tibetan Autonomous Prefecture , Sichuan, China

2020 ◽  
Author(s):  
Cheng Li ◽  
Yongqi Bai ◽  
Mingcai Zeng ◽  
Yong Luo ◽  
Chumu Luorong ◽  
...  
Keyword(s):  
Vitamin A ◽  
Cystic Echinococcosis ◽  
Serum Levels ◽  
Sichuan Province ◽  
Healthy Controls ◽  
Age And Gender ◽  
Female Ratio ◽  
Socioeconomic Burden ◽  
And Gender ◽  
Male To Female

Abstract Background Cystic echinococcus (CE), endemic in Asia, causes disease resulting in a high socioeconomic burden. Methods Eighty-nine echinococcosis patients and 274 controls from the Aba and Garze Tibetan Autonomous Prefecture of Sichuan province in China were recruited. The serum levels of Selenium (Se) and vitamin A (VA) of the cases and controls were detected and stratified by age and gender. Results The results showed that the male to female ratio of the patients was 1:1.97. The echinococcosis patients were mainly adults. It was confirmed that the serum levels of VA and age were correlated. Compared with the healthy controls, the serum levels of Se and VA of the cases significantly declined in both children and adults. Conclusions It was confirmed that the serum levels of Se and VA were interrelated with the prevalence of echinococcosis.

scholarly journals Neurotrophins, cytokines, oxidative parameters and funcionality in Progressive Muscular Dystrophies

2015 ◽  
Vol 87 (3) ◽  
pp. 1809-1818 ◽  
Author(s):  
CLARISSA M. COMIM ◽  
GISIANE B. MATHIA ◽  
ANDREZA HOEPERS ◽  
LISIANE TUON ◽  
FLÁVIO KAPCZINSKI ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Muscular Dystrophy ◽  
Inflammatory Cytokine ◽  
Serum Levels ◽  
Superoxide Dismutase Activity ◽  
Age And Gender ◽  
Tnf Α ◽  
Cytokine Levels ◽  
And Gender ◽  
Anti Inflammatory Cytokine

We investigated the levels of brain derived-neurotrophic factor (BDNF), cytokines and oxidative parameters in serum and tried to correlate them with the age and functionality of patients with Progressive Muscle Dystrophies (PMD). The patients were separated into six groups (case and controls pared by age and gender), as follows: Duchenne Muscular Dystrophy (DMD); Steinert Myotonic Dystrophy (SMD); and Limb-girdle Muscular Dystrophy type-2A (LGMD2A). DMD patients (±17.9 years old) had a decrease of functionality, an increase in the IL-1β and TNF-α levels and a decrease of IL-10 levels and superoxide dismutase activity in serum. SMD patients (±25.8 years old) had a decrease of BDNF and IL-10 levels and superoxide dismutase activity and an increase of IL-1β levels in serum. LGMD2A patients (±27.7 years old) had an decrease only in serum levels of IL-10. This research showed the first evidence of BDNF involvement in the SMD patients and a possible unbalance between pro-inflammatory and anti-inflammatory cytokine levels, along with decreased superoxide dismutase activity in serum of DMD and SMD patients.

scholarly journals Decreased Serum Hepatocyte Growth Factor (HGF) in Individuals with Bipolar Disorder Normalizes after Zinc and Anti-oxidant Therapy

2010 ◽  
Vol 3 ◽  
pp. NMI.S5528 ◽  
Author(s):  
A.J. Russo
Keyword(s):  
Bipolar Disorder ◽  
Serum Concentration ◽  
Inductively Coupled Plasma ◽  
Serum Levels ◽  
Age And Gender ◽  
Inductively Coupled ◽  
Plasma Mass Spectrometry ◽  
And Gender ◽  
Zinc Levels ◽  
Bipolar Patients

Aim To assess serum HGF concentration in individuals with bipolar disorder and investigate the efficacy of zinc therapy on these levels. Subjects and Methods Serum from 35 individuals diagnosed with bipolar disorder and 19 age and gender similar controls were tested for HGF concentration using ELISAs, and copper and zinc plasma levels using inductively-coupled plasma-mass spectrometry. Results HGF serum levels of individuals with bipolar disorder were significantly lower than age and gender similar controls ( P = 0.0021). HGF serum concentration was significantly lower in Bipolar patients pre-therapy ( P = 0.0009) and HGF levels normalized post-therapy. Zinc levels in these same individuals also normalized ( P = 0.0046) and patient's perceived severity of Bipolar symptoms significantly decreased after therapy ( P = 0.0003). We also found a significant direct correlation between Zinc and HGF serum concentration in the bipolar patients ( P = 0.04). Discussion These results suggest an association between low HGF levels and bipolar disorder and also demonstrate that zinc therapy may be associated with the normalization of HGF levels and decrease in severity of disease.

scholarly journals Physical Activity and Quality of Life in Hemodialysis Patients and Healthy Controls: A Cross-Sectional Study

2021 ◽  
Vol 18 (4) ◽  
pp. 1978
Author(s):  
Tjaša Filipčič ◽  
Špela Bogataj ◽  
Jernej Pajek ◽  
Maja Pajek
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Everyday Life ◽  
Habitual Physical Activity ◽  
Healthy Controls ◽  
Age And Gender ◽  
Comorbidity Score ◽  
Sf 36 ◽  
And Gender

Hemodialysis (HD) patients have lower functional abilities compared to healthy people, and this is associated with lower physical activity in everyday life. This may affect their quality of life, but research on this topic is limited. Therefore, the present study aimed to determine the relationship between habitual physical activity and quality of life in HD patients and healthy controls. Ninety-three HD patients and 140 controls participated in the study. Quality of life was assessed using a 36-item medical outcomes study short-form health survey (SF-36). Human Activity Profile (HAP) was used to assess habitual physical activity. The adjusted activity score (AAS) from HAP, age, gender, fat tissue index (FTI), lean tissue index (LTI), and Davies comorbidity score were analyzed as possible predictors of the Physical Component Summary (PCS) of the SF-36. Three sequential linear models were used to model PCS. In Model 1, PCS was regressed by gender and age; in Model 2 the LTI, FTI, and Davies comorbidity scores were added. Model 3 also included AAS. After controlling for age and gender (ModelHD 1: p = 0.056), LTI, FTI, and Davies comorbidity score effects (ModelHD 2: p = 0.181), the AAS accounted for 32% of the variation in PCS of HD patients (ModelHD 3: p < 0.001). Consequently, the PCS of HD patients would increase by 0.431 points if the AAS increased by one point. However, in healthy controls, AAS had a lower impact than in the HD sample (B = 0.359 vs. 0.431), while the corresponding effects of age and gender (ModelH 1: p < 0.001), LTI, FTI, and Davies comorbidity score (ModelH 2: p < 0.001) were adjusted for. The proportion of variation in PCS attributed to AAS was 14.9% (ModelH 3: p < 0.001). The current study results showed that physical activity in everyday life as measured by the HAP questionnaire is associated to a higher degree with the quality of life of HD patients than in healthy subjects. Routine physical activity programs are therefore highly justified, and the nephrology community should play a leading role in this effort.

scholarly journals Age- and Gender-Related Differences in LDL-Cholesterol Management in Outpatients with Type 2 Diabetes Mellitus

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Giuseppina Russo ◽  
Basilio Pintaudi ◽  
Carlo Giorda ◽  
Giuseppe Lucisano ◽  
Antonio Nicolucci ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Serum Levels ◽  
Diabetes Duration ◽  
Lipid Lowering ◽  
Age And Gender ◽  
Chd Risk ◽  
And Gender

Background. Dyslipidemia contribute to the excess of coronary heart disease (CHD) risk observed in women with type 2 diabetes (T2DM). Low density lipoprotein-cholesterol (LDL-C) is the major target for CHD prevention, and T2DM women seem to reach LDL-C targets less frequently than men.Aim. To explore age- and gender-related differences in LDL-C management in a large sample of outpatients with T2DM.Results. Overall, 415.294 patients (45.3% women) from 236 diabetes centers in Italy were included. Women were older and more obese, with longer diabetes duration, higher total-cholesterol, LDL-C, and HDL-C serum levels compared to men (P<0.0001). Lipid profile was monitored in ~75% of subjects, women being monitored less frequently than men, irrespective of age. More women did not reach the LDL-C target as compared to men, particularly in the subgroup treated with lipid-lowering medications. The between-genders gap in reaching LDL-C targets increased with age and diabetes duration, favouring men in all groups.Conclusions. LDL-C management is worst in women with T2DM, who are monitored and reach targets less frequently than T2DM men. Similarly to men, they do not receive medications despite high LDL-C. These gender discrepancies increase with age and diabetes duration, exposing older women to higher CHD risk.

Hair Magnesium content and its relation to Serum Magnesium level in children with Idiopathic Epilepsy

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Hamed Mahmoud Shatla ◽  
Mariam Fathy Abdel Maksoud ◽  
Raghda Mohamed Hesham Zaitoun ◽  
Alaa Rabie Abdel Baset Mahmoud
Keyword(s):  
Serum Magnesium ◽  
Serum Levels ◽  
Magnesium Content ◽  
Magnesium Level ◽  
Idiopathic Epilepsy ◽  
Age And Gender ◽  
Control Subjects ◽  
Significant Difference ◽  
And Gender ◽  
Patients With Epilepsy

Abstract Objective To measure the level of hair Mg, as well as its level in serum, in patients with epilepsy and compare them to the levels found in non-epileptic age and gender matched children, and to explore any potential correlation between either serum or hair level of magnesium and seizure characteristics in children with idiopathic epilepsy. Methods An observational cross-sectional study including 50 children with idiopathic epilepsy and 100 non-epileptic age and gender matched control subjects. Cases were subjected to full history taking, examination and measurements of serum and hair levels of magnesium, control subjects only had their serum and hair level of magnesium measured as for the cases. Results The mean serum magnesium was 29.11 ± 13.42 ug/ml for cases and 27.67 ± 7.24 ug/ml for controls and the median hair level of magnesium was 42.22 ug/g with IQR of 25.9 - 56.82 for cases and 38.6 ug/g with IQR of 25.21 - 61.25 for controls. No statistically significant difference was observed between both groups as regards either serum or hair magnesium levels. No statistically significant correlation was observed between either hair or serum levels of magnesium and seizure characteristics though the correlations were nearing statistical significance for the hair magnesium content. Conclusion Hair magnesium level may be better correlated to seizure characteristics and control than serum levels in patients with epilepsy.

scholarly journals Respiratory changes in Parkinson's disease may be unrelated to dopaminergic dysfunction

2012 ◽  
Vol 70 (11) ◽  
pp. 847-851 ◽  
Author(s):  
Luciana Ulhôa Guedes ◽  
Juliana Melo Rodrigues ◽  
Aline Andrioni Fernandes ◽  
Francisco E. Cardoso ◽  
Verônica Franco Parreira
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Statistical Analysis ◽  
Healthy Controls ◽  
Maximal Inspiratory Pressure ◽  
Age And Gender ◽  
Dopaminergic Dysfunction ◽  
And Gender ◽  
Student’S T ◽  
Student’S T Test

OBJECTIVE: To investigate the maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) in patients with Parkinson's disease (PD) during the on and off periods of levodopa and to compare with healthy controls. METHODS: Twenty-six patients were analyzed with Hoehn and Yahr scores (2-3) and 26 age and gender matched-controls. Statistical analysis was performed with Student's t-test for paired and independent samples. RESULTS: MIP and MEP values in patients were significantly lower than the values obtained in controls both for off and on stages -excepted for MIP in women (p=0.28). For patients with PD, the studied parameters did not differ between stages on and off, with the exception of MEP in women (p=0.00). CONCLUSIONS: Patients with PD have respiratory pressure lower than controls, even in early stages of the disease, and dopamine replacement has little impact over these respiratory pressures. These findings suggest that respiratory changes in PD may be unrelated to dopaminergic dysfunction.

Sign in / Sign up

Export Citation Format

Share Document