Researching Reactions to Capsule Cigarettes Using Choice Modeling Methods

2020 ◽  
Keyword(s):  
Choice Modeling ◽  
Modeling Methods

scholarly journals Using the Contingent Grouping Method to Value Forest Attributes

ISRN Forestry ◽  
2013 ◽  
Vol 2013 ◽  
pp. 1-8
Author(s):  
Pere Riera ◽  
Joan Mogas ◽  
Raul Brey
Keyword(s):  
Stated Preference ◽  
Choice Modeling ◽  
Welfare Loss ◽  
Land Productivity ◽  
Modeling Methods ◽  
Valuation Method ◽  
Contingent Choice ◽  
Marginal Values ◽  
Grouping Method ◽  
Afforestation Program

This paper presents the first application of a recently proposed stated preference valuation method called contingent grouping. The method is an alternative to other choice modeling methods such as contingent choice or contingent ranking. It was applied to an afforestation program in the northeast of Spain. The attributes included (and the marginal values estimated per individual) were allowing picnicking in the new forests (€2.47), sequestering 1000 tons of CO2 (€0.04), delaying the loss of land productivity by 100 years, due to erosion in the new forests area (€0.783), and allowing four-wheel driving (€6.5), which is perceived as a welfare loss.

Image Analysis of Intramembrane Particles in Freeze-Fractured Biomembranes Using Computer Simulation Techniques

1975 ◽  
Vol 33 ◽  
pp. 214-215
Author(s):  
D.J. Benefiel ◽  
R.S. Weinstein
Keyword(s):  
Membrane Proteins ◽  
Freeze Fracture ◽  
Integral Membrane Proteins ◽  
Systematic Evaluation ◽  
Intramembrane Particles ◽  
Modeling Methods ◽  
Simulation Techniques ◽  
Freeze Fracture Electron Microscopy ◽  
Fracture Electron ◽  
Computer Simulation Techniques

Intramembrane particles (IMP or MAP) are components of most biomembranes. They are visualized by freeze-fracture electron microscopy, and they probably represent replicas of integral membrane proteins. The presence of MAP in biomembranes has been extensively investigated but their detailed ultrastructure has been largely ignored. In this study, we have attempted to lay groundwork for a systematic evaluation of MAP ultrastructure. Using mathematical modeling methods, we have simulated the electron optical appearances of idealized globular proteins as they might be expected to appear in replicas under defined conditions. By comparing these images with the apearances of MAPs in replicas, we have attempted to evaluate dimensional and shape distortions that may be introduced by the freeze-fracture technique and further to deduce the actual shapes of integral membrane proteins from their freezefracture images.

Consumer Choice Modeling via TOPSIS

2009 ◽  
Author(s):  
Suresh K. Bhatt ◽  
Namita Bhatnagar ◽  
S. S. Appadoo
Keyword(s):  
Consumer Choice ◽  
Choice Modeling

Evaluation of the functional tension of foreign medical student’s organisms in adapting to educational activities

2020 ◽  
pp. 755-755
Author(s):  
N. K. Smagulov ◽  
A. A. Adilbekova ◽  
N. V. Gitenis
Keyword(s):  
Mathematical Modeling ◽  
Foreign Students ◽  
Educational Process ◽  
Educational Activities ◽  
Modeling Methods ◽  
Functional Stress

The use of mathematical modeling methods allowed us to develop criteria for functional stress for assessing and predicting the level of functional stress of foreign students in the process of adaptation to the educational process.

FEATURES OF ORGANOPHOSPHATES IMMOBILIZATION VIA STREPTAVIDIN-BIOTIN SYSTEM FOR EXPERIMENTS ON SELECTION OF APTAMERS

2020 ◽  
pp. 12-20
Author(s):  
D. A. Belinskaya ◽  
Yu. V. Chelusnova ◽  
V. V. Abzianidze ◽  
N. V. Goncharov
Keyword(s):  
Polyethylene Glycol ◽  
Organophosphorus Compounds ◽  
Binding Energies ◽  
Rna Aptamers ◽  
Main Method ◽  
Modeling Methods ◽  
Molecular Dynamics Methods ◽  
Systematic Evolution ◽  
Exponential Enrichment ◽  
Selection Of

Poisoning with organophosphorus compounds occupy one of the leading places in exotoxicosis. At the first stage, the detoxification of organophosphates can be provided with the help of DNA or RNA aptamers that bind the poison in the bloodstream. Currently, the main method of searching for aptamers is the experimental method of systematic evolution of ligands by exponential enrichment (SELEX). In the process of aptamer selection, the target molecule must be immobilized via the streptavidin-biotin complex. Since the poison molecule is small in size, to increase its availability for binding to aptamer, it is necessary to use a spacer between organophosphorus compounds and biotin. The aim of this work was to optimize the selection of aptamers for organophosphorus compounds by increasing the availability of a poison molecule immobilized via the streptavidin-biotin complex on the example of paraoxon. For this purpose, three spacers between organophosphorus compounds and biotin were tested using molecular modeling methods: three links of polyethylene glycol (3-PEG), four links of polyethylene glycol (4-PEG) and aminohexyl. The conformation of the biotinylated paraoxon complex with streptavidin and the interaction of paraoxon with the binding fragment of the aptamer were modeled using molecular docking and molecular dynamics methods. The ability of biotinylated paraoxon to bind to the aptamer has been evaluated by analyzing the surface area of the paraoxon available to the solvent, as well as by calculating the free binding energies. It has been shown that only in the case of aminohexyl immobilized paraoxon can contact the aptamer. At the final stage, the synthesis of paraoxon bound to biotin via aminohexyl was carried out.

Investigation of Isoindolo[2,1-a]quinoxaline-6-imines as Topoisomerase I Inhibitors with Molecular Modeling Methods

2017 ◽  
Vol 13 (3) ◽  
Author(s):  
Balazs Balogh ◽  
Anna Carbone ◽  
Virginia Spanò ◽  
Alessandra Montalbano ◽  
Paola Barraja ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Topoisomerase I ◽  
Modeling Methods ◽  
Topoisomerase I Inhibitors
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