topoisomerase i inhibitors Latest Research Papers

Synthesis of Hybrid Phosphorated Indenoquinolines and Biological Evaluation as Topoisomerase I Inhibitors and Antiproliferative agents

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2021.128517 ◽

2021 ◽

pp. 128517

Author(s):

María Fuertes ◽

Asier Selas ◽

Angela Trejo ◽

Birgitta R. Knudsen ◽

Francisco Palacios ◽

...

Keyword(s):

Topoisomerase I ◽

Biological Evaluation ◽

Antiproliferative Agents ◽

Topoisomerase I Inhibitors

Download Full-text

Design and synthesis of novel conformationally constrained 7,12-dihydrodibenzo[b,h][1,6] naphthyridine and 7H-Chromeno[3,2-c] quinoline derivatives as topoisomerase I inhibitors: in vitro screening, molecular docking and ADME predictions

Bioorganic Chemistry ◽

10.1016/j.bioorg.2021.105174 ◽

2021 ◽

pp. 105174

Author(s):

Ramakant A. Kardile ◽

Aniket P. Sarkate ◽

Avinash S. Borude ◽

Rajendra S. Mane ◽

Deepak K. Lokwani ◽

...

Keyword(s):

Molecular Docking ◽

Topoisomerase I ◽

Quinoline Derivatives ◽

In Vitro Screening ◽

Conformationally Constrained ◽

Design And Synthesis ◽

Topoisomerase I Inhibitors

Download Full-text

Design, synthesis, and anticancer activities of 8,9-substituted Luotonin A analogs as novel topoisomerase I inhibitors

Medicinal Chemistry Research ◽

10.1007/s00044-021-02749-y ◽

2021 ◽

Author(s):

Yuanhang Xiang ◽

Haiping Li ◽

Jun Wang ◽

Xiaozhi Peng ◽

Chunling Hu ◽

...

Keyword(s):

Topoisomerase I ◽

Anticancer Activities ◽

Design Synthesis ◽

Topoisomerase I Inhibitors ◽

Luotonin A

Download Full-text

Fused chromeno and quinolino[1,8]naphthyridines: synthesis and biological evaluation as topoisomerase I inhibitors and antiproliferative agents

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2021.116177 ◽

2021 ◽

pp. 116177

Author(s):

Endika Martín-Encinas ◽

Gloria Rubiales ◽

Birgitta R. Knudsen ◽

Francisco Palacios ◽

Concepción Alonso

Keyword(s):

Topoisomerase I ◽

Biological Evaluation ◽

Antiproliferative Agents ◽

Topoisomerase I Inhibitors ◽

Synthesis And Biological Evaluation

Download Full-text

Discovery of 4-alkoxy-2-aryl-6,7-dimethoxyquinolines as a new class of topoisomerase I inhibitors endowed with potent in vitro anticancer activity

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2021.113261 ◽

2021 ◽

Vol 215 ◽

pp. 113261

Author(s):

Mostafa M. Elbadawi ◽

Wagdy M. Eldehna ◽

Wenjie Wang ◽

Keli K. Agama ◽

Yves Pommier ◽

...

Keyword(s):

Anticancer Activity ◽

Topoisomerase I ◽

New Class ◽

Topoisomerase I Inhibitors

Download Full-text

Copper(I)-Catalyzed Nitrile-Addition/N-Arylation Ring-Closure Cascade: Synthesis of 5,11-Dihydro-6H-indolo[3,2-c]quinolin-6-ones as Potent Topoisomerase-I Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.0c00727 ◽

2021 ◽

Vol 64 (3) ◽

pp. 1435-1453

Author(s):

Wen-Yun Hsueh ◽

Ying-Shuan E. Lee ◽

Min-Sian Huang ◽

Chin-Hung Lai ◽

Yu-Sheng Gao ◽

...

Keyword(s):

Topoisomerase I ◽

Ring Closure ◽

Topoisomerase I Inhibitors

Download Full-text

A patent review of topoisomerase I inhibitors (2016-present)

Expert Opinion on Therapeutic Patents ◽

10.1080/13543776.2021.1879051 ◽

2021 ◽

Author(s):

Asier Selas ◽

Endika Martin-Encinas ◽

Maria Fuertes ◽

Carme Masdeu ◽

Gloria Rubiales ◽

...

Keyword(s):

Topoisomerase I ◽

Topoisomerase I Inhibitors ◽

Patent Review

Download Full-text

Concise synthesis and in vitro anticancer activity of benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-ones (BBPIs), topoisomerase I inhibitors based on the marine alkaloid lamellarin

Bioscience Biotechnology and Biochemistry ◽

10.1093/bbb/zbaa028 ◽

2021 ◽

Vol 85 (1) ◽

pp. 181-191

Author(s):

Fumito Ishibashi ◽

Tsutomu Fukuda ◽

Shijiao Zha ◽

Aya Hashirano ◽

Shotaro Hirao ◽

...

Keyword(s):

Heck Reaction ◽

Topoisomerase I ◽

Normal Cell ◽

Ring System ◽

Marine Natural Product ◽

Anticancer Compounds ◽

Topoisomerase I Inhibitors ◽

Marine Alkaloid ◽

Intramolecular Heck Reaction

Abstract Benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-ones (BBPIs) are potent anticancer compounds having unique BBPIs ring system designed on the basis of the marine natural product lamellarin D. In this study, we describe an alternative synthesis of a 2-demethoxy series of BBPIs, employing van Leusen pyrrole synthesis and an intramolecular Heck reaction as the key reactions. Cytotoxicity of the derivatives against several cancer and normal cell lines is reported.

Download Full-text

Multi-Cohort Retrospective Validation of a Predictive Biomarker for Topoisomerase I Inhibitors

Clinical Colorectal Cancer ◽

10.1016/j.clcc.2020.11.005 ◽

2020 ◽

Author(s):

Koji Ando ◽

Al Ozonoff ◽

Shin-Yin Lee ◽

Michael Viosine ◽

Julian-Taylor Parker ◽

...

Keyword(s):

Topoisomerase I ◽

Predictive Biomarker ◽

Topoisomerase I Inhibitors

Download Full-text

The bromodomain and extra-terminal domain inhibitor JQ1 synergistically sensitizes human colorectal cancer cells to topoisomerase I inhibitors through repression of Mre11-mediated DNA repair pathway

Investigational New Drugs ◽

10.1007/s10637-020-01014-0 ◽

2020 ◽

Author(s):

Linping Lei ◽

Xuqin Xie ◽

Long He ◽

Keling Chen ◽

Zhaoying Lv ◽

...

Keyword(s):

Colorectal Cancer ◽

Dna Repair ◽

Cancer Cells ◽

Topoisomerase I ◽

Repair Pathway ◽

Human Colorectal Cancer ◽

Topoisomerase I Inhibitors ◽

Terminal Domain ◽

Colorectal Cancer Cells ◽

Human Colorectal Cancer Cells

Download Full-text

topoisomerase i inhibitors
Recently Published Documents

TOTAL DOCUMENTS

H-INDEX

Synthesis of Hybrid Phosphorated Indenoquinolines and Biological Evaluation as Topoisomerase I Inhibitors and Antiproliferative agents

Design and synthesis of novel conformationally constrained 7,12-dihydrodibenzo[b,h][1,6] naphthyridine and 7H-Chromeno[3,2-c] quinoline derivatives as topoisomerase I inhibitors: in vitro screening, molecular docking and ADME predictions

Design, synthesis, and anticancer activities of 8,9-substituted Luotonin A analogs as novel topoisomerase I inhibitors

Fused chromeno and quinolino[1,8]naphthyridines: synthesis and biological evaluation as topoisomerase I inhibitors and antiproliferative agents

Discovery of 4-alkoxy-2-aryl-6,7-dimethoxyquinolines as a new class of topoisomerase I inhibitors endowed with potent in vitro anticancer activity

Copper(I)-Catalyzed Nitrile-Addition/N-Arylation Ring-Closure Cascade: Synthesis of 5,11-Dihydro-6H-indolo[3,2-c]quinolin-6-ones as Potent Topoisomerase-I Inhibitors

A patent review of topoisomerase I inhibitors (2016-present)

Concise synthesis and in vitro anticancer activity of benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-ones (BBPIs), topoisomerase I inhibitors based on the marine alkaloid lamellarin

Multi-Cohort Retrospective Validation of a Predictive Biomarker for Topoisomerase I Inhibitors

The bromodomain and extra-terminal domain inhibitor JQ1 synergistically sensitizes human colorectal cancer cells to topoisomerase I inhibitors through repression of Mre11-mediated DNA repair pathway

Export Citation Format

topoisomerase i inhibitorsRecently Published Documents

TOTAL DOCUMENTS

H-INDEX

Synthesis of Hybrid Phosphorated Indenoquinolines and Biological Evaluation as Topoisomerase I Inhibitors and Antiproliferative agents

Design and synthesis of novel conformationally constrained 7,12-dihydrodibenzo[b,h][1,6] naphthyridine and 7H-Chromeno[3,2-c] quinoline derivatives as topoisomerase I inhibitors: in vitro screening, molecular docking and ADME predictions

Design, synthesis, and anticancer activities of 8,9-substituted Luotonin A analogs as novel topoisomerase I inhibitors

Fused chromeno and quinolino[1,8]naphthyridines: synthesis and biological evaluation as topoisomerase I inhibitors and antiproliferative agents

Discovery of 4-alkoxy-2-aryl-6,7-dimethoxyquinolines as a new class of topoisomerase I inhibitors endowed with potent in vitro anticancer activity

Copper(I)-Catalyzed Nitrile-Addition/N-Arylation Ring-Closure Cascade: Synthesis of 5,11-Dihydro-6H-indolo[3,2-c]quinolin-6-ones as Potent Topoisomerase-I Inhibitors

A patent review of topoisomerase I inhibitors (2016-present)

Concise synthesis and in vitro anticancer activity of benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-ones (BBPIs), topoisomerase I inhibitors based on the marine alkaloid lamellarin

Multi-Cohort Retrospective Validation of a Predictive Biomarker for Topoisomerase I Inhibitors

The bromodomain and extra-terminal domain inhibitor JQ1 synergistically sensitizes human colorectal cancer cells to topoisomerase I inhibitors through repression of Mre11-mediated DNA repair pathway

topoisomerase i inhibitors
Recently Published Documents