T47D cell-inhibiting indonesian medicinal plants and active constituents of Alpinia galanga rhizome

2018 ◽  
Vol 14 (56) ◽  
pp. 359
Author(s):  
Azis Saifudin ◽  
Muhammad Dai ◽  
Arini Fadhilah ◽  
Juwita Rahmawati ◽  
AlfianMahardika Forentin ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
T47d Cell ◽  
Active Constituents ◽  
Alpinia Galanga

scholarly journals Studies on Active Constituents in Medicinal Plants Using the Receptor Binding Assay. II. : Dopamine 2 Receptor

1988 ◽  
Vol 108 (5) ◽  
pp. 450-453
Author(s):  
TOSIHIKO SUMIDA ◽  
HIROYUKI SUGIMOTO ◽  
TOHRU FUWA ◽  
KAZUO YAMASAKI ◽  
OSAMU TAKEDA ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Receptor Binding ◽  
Binding Assay ◽  
Active Constituents ◽  
Receptor Binding Assay ◽  
Dopamine 2 Receptor

scholarly journals Antiparasitic Metabolites from Hyptis brevipes, a Tacana Medicinal Plant

2019 ◽  
Vol 14 (1) ◽  
pp. 1934578X1901400 ◽  
Author(s):  
Ivan Limachi ◽  
Claudia Condo ◽  
Camila Palma ◽  
Nelida Nina ◽  
Efrain Salamanca ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Nmr Spectroscopy ◽  
Medicinal Plants ◽  
Medicinal Plant ◽  
Trypanosoma Cruzi ◽  
Hela Cells ◽  
Giardia Lamblia ◽  
Structure Elucidation ◽  
Intestinal Parasites ◽  
Active Constituents

A bioassay screening against protozoa parasites of several Tacana medicinal plants gave Hyptis brevipes (Id'ene eidhue), traditionally used as decoction for intestinal parasites, as the most active extract. In this work we did a bioguided isolation of active constituents found in leaves. Structure elucidation was carried out by NMR spectroscopy and MS spectrometry analyses. Active constituents showed differentiated activity towards Giardia lamblia, Trypanosoma cruzi, several Leishmania strains, Plasmodium falciparum and cytotoxicity against HeLa cells. Brevipolide H (1) was the less cytotoxic and best antiparasitic, while the catechol derivative (2) the most active and cytotoxic.

scholarly journals Turmeric and Ginger as Health Protective Food Sources - An Integrative Review

2021 ◽  
Vol 24 (02) ◽  
Author(s):  
P.A.L. Jayathilake ◽  
M. A. Jayasinghe ◽  
J. Walpita ◽  
K.P.R.I. Dilani
Keyword(s):  
Medicinal Plants ◽  
Traditional Medicine ◽  
Human Health ◽  
Human Body ◽  
Broad Spectrum ◽  
Antimicrobial Properties ◽  
Food Sources ◽  
Active Constituents ◽  
Protective Food ◽  
Pharmacological Potential

Most of the medicinal plants utilized in traditional medicine are spices. Majority of those spices are widely used for aroma, flavour and colour in cuisine though they behave as appetizers, digestives, preventives and aphrodisiacs. Their antimicrobial properties are in a broad spectrum that provides a considerable immunity development within the human body. This review summarizes the beneficial characteristics of major active constituents in turmeric and ginger and their presumed pharmacological potential to safeguard human health.Keywords: Turmeric, Ginger, Curcumin, Human health, Active Ingredients, Nanotechnology

scholarly journals Alpinia galanga Derived Phytochemicals against Shikimate Dehydrogenase Causing Peptic Ulcer

2020 ◽  
pp. 117-119
Author(s):  
Sonali Parida ◽  
Sutapa Nayak ◽  
Seema Suvadarshini ◽  
G. K. Panigrahi ◽  
Sitaram Swain ◽  
...  
Keyword(s):  
Health Care ◽  
Peptic Ulcer ◽  
Medicinal Plants ◽  
Shikimate Dehydrogenase ◽  
Alpinia Galanga ◽  
Discovery Studio ◽  
Docking Method ◽  
Microbial Action ◽  
Different Parts ◽  
Molecular Docking Method

Phytochemicals can be derived from different parts of plants. Different medicinal plants and their phytoextracts have shown anti-microbial action. These medicinal plants play a key role in human health care. Phytochemicals from Alpinia galanga plant extract are traditionally used to cure Peptic Ulcer. The objective of the study is to identify the phytochemical of Alpinia galanga capable of curing Peptic Ulcer. Molecular docking method applied using “Biovia Discovery Studio”. “High positive values of -CDOCKER energy and -CDOCKER interaction energy” suggested that Alpinia galanga derived Phytochemicals cannot act effectively against Peptic Ulcer caused by Helicobacter pylori.

scholarly journals Plants as Immunity Enhancers: A Review

2021 ◽  
Vol 23 (08) ◽  
pp. 92-106
Author(s):  
◽  
Payal Mittal ◽  
Keyword(s):  
Immune System ◽  
Medicinal Plants ◽  
Research Area ◽  
Present Review ◽  
Active Principle ◽  
Active Constituents ◽  
Herbal Plants ◽  
Ancient Times

It is an evident from ancient times that herbs and medicinal plants have the potential to cure a variety of diseases. Some plants boosts our immunity and make our immune system more powerful to fight againt various diseases. The medicinal effects shown by the plants are due to active principle compound present in them and they work in the same manner as the conventioal drugs. Indian herbs and medicinal plants show miraculous effects against wide variety of diseases and disorders in humansand can be better called as “elixers of life”. Currently, the interest is increasing with high pace in the use of active constituents of medicinal plants as modulator or enhancer of complex immune system. From the literature of various studies carried out in the research area , it is culminated that many of the chemicals in the form of alkaloids, flavanoids, anti-oxidants, tannins, terpenes, and glycoside products are responsible to empower the immunmodulator effect. Keeping in mind , the appreciating potential of active constituents of medicinal plants and their derived drugs, present review is an attemptto globally popularize the herbal plants with Immunomodulator Activity.

scholarly journals Medicinal Plants Used in the Management of Psychosis

2021 ◽  
Author(s):  
Sunday Oritsetimenyin Otimenyin ◽  
Lydia Doosuur Ior
Keyword(s):  
Medicinal Plants ◽  
Adverse Effects ◽  
Conventional Treatment ◽  
Molecular Mechanisms ◽  
Mental Health Problems ◽  
Holistic Approach ◽  
Active Constituents ◽  
Alternative Medicines ◽  
The Central Nervous System ◽  
Typical And Atypical Antipsychotics

Substantial number of studies has been conducted to find alternatives or treatments for psychosis. Psychosis represents a variety of mental disorders characterized by the presence of delusions, hallucinations and grossly disorganized thinking in a clear sensorium. Psychosis is burdensome and difficult to treat given the inability of the typical and atypical antipsychotics to adequately manage it, accompanied by numerous disturbing adverse effects. Therefore, many with chronic mental health problems justifiably feel disappointed by the apparent ineffectiveness of conventional treatment and naturally search for a more holistic approach to treatment and alternative medicines having less or no side-effects. Plants are rich in secondary metabolites which have the ability to interact with the Central nervous system (CNS) to produce effects that can be beneficial for the management of psychosis, these phytochemicals are believed to have minimal adverse effects. A review of some of the medicinal plants used as antipsychotics, indicated that many medicinal plants possess antipsychotic effects that can improve the treatment of psychosis. Apparently, further studies are necessary in order to isolate the active constituents, ascertain their molecular mechanisms and safety, and also to test them in clinical studies for the development of new pharmacotherapies for psychosis.

scholarly journals RECENT ADVANCES IN APPLICATIONS OF ACTIVE CONSTITUENTS OF SELECTED MEDICINAL PLANTS OF DHOFAR, SULTANATE OF OMAN

2018 ◽  
Vol 11 (4) ◽  
pp. 28
Author(s):  
Israr Ul Hassan ◽  
Mohammed Idrees ◽  
Gowhar Ahmad Naikoo ◽  
Luay Rashan ◽  
Abdelbary Elhissi ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Secondary Metabolism ◽  
Review Article ◽  
Wild Plants ◽  
Primary Metabolism ◽  
Plant Biodiversity ◽  
Sultanate Of Oman ◽  
Active Constituents ◽  
Medicinal Properties ◽  
Selection Of

 The Dhofar region of Oman is extremely opulent in plant biodiversity in comparison to other parts of the country. Most of the cultivated, medicinal and wild plants of the region are available in the mountainous side and hilly areas of Dhofar. The plants produce products from primary metabolism and others from secondary metabolism. On the basis of active constituents plants can be categorized into two groups:1. Medicinal plants and2. Aromatic plants.Over 250 complex chemicals have been recognized and extracted from herbal sources. In this review article, we discuss a selection of medicinal plants of the Dhofar region of Oman which are rich in active constituents and through recent reports discuss the application of the most active constituents. Among the medicinal plants of the Dhofar region, frankincense is also a well-known indicator of the region and has a unique position through its medicinal properties of its oil and gum resin.

scholarly journals Potential Antiosteoporotic Agents from Plants: A Comprehensive Review

2012 ◽  
Vol 2012 ◽  
pp. 1-28 ◽  
Author(s):  
Min Jia ◽  
Yan Nie ◽  
Da-Peng Cao ◽  
Yun-Yun Xue ◽  
Jie-Si Wang ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Health Hazard ◽  
Clinical Effectiveness ◽  
Pharmacological Properties ◽  
Medical Systems ◽  
Major Health ◽  
Comprehensive Review ◽  
Active Constituents ◽  
Pharmacological Data ◽  
Future Drug

Osteoporosis is a major health hazard and is a disease of old age; it is a silent epidemic affecting more than 200 million people worldwide in recent years. Based on a large number of chemical and pharmacological research many plants and their compounds have been shown to possess antiosteoporosis activity. This paper reviews the medicinal plants displaying antiosteoporosis properties including their origin, active constituents, and pharmacological data. The plants reported here are the ones which are commonly used in traditional medical systems and have demonstrated clinical effectiveness against osteoporosis. Although many plants have the potential to prevent and treat osteoporosis, so far, only a fraction of these plants have been thoroughly investigated for their physiological and pharmacological properties including their mechanism of action. An attempt should be made to highlight plant species with possible antiosteoporosis properties and they should be investigated further to help with future drug development for treating this disease.

scholarly journals Selectivity Index of Alpinia galanga Extract and 1’-Acetoxychavicol Acetate on Cancer Cell Lines

2019 ◽  
Vol 10 (2) ◽  
pp. 95
Author(s):  
Muhammad Da'i ◽  
Khairunnisa Azani Meilinasary ◽  
Andi Suhendi ◽  
Sari Haryanti
Keyword(s):  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Cell Lines ◽  
Cancer Cell ◽  
Ethanol Extract ◽  
T47d Cell ◽  
Cancer Cell Lines ◽  
Selectivity Index ◽  
Methanol Fraction ◽  
Alpinia Galanga

Previous research stated that galangal (Alpinia galanga) extract has a potential as cytotoxic agent with active compound of 1’-Acetoxychavicol Acetate (ACA). The objective of this study was to determine the selectivity of ethanol extract, ethyl acetate fraction, and methanol fraction of of galangal, and ACA on cancer cell lines. Cytotoxic activity was carried out using the MTT method on T47D breast cancer, WiDr colon cancer, HeLa cervical cancer, and Vero normal cell lines. The results showed that galangal ethanol extract and its fractions had selectivity index equal to or less than 2 on cancer cells. Meanwhile, ACA had selectivity index more than 3 on T47D cell and HeLa cell. ACA showed a strong cytotoxic activity against cancer cells T47D, HeLa, and WiDr with IC50 values of 3.14, 7.26, and 12.49 μg/ml, respectively. Based on data, it could be concluded that ACA was the most selective to inhibit T47D cell with a selectivity index of 6.6.Keywords: 1’-Acetoxychavicol acetate, galangal (Alpinia galanga), selective index, cytotoxic

Sign in / Sign up

Export Citation Format

Share Document