Rasam (South Indian Spice Soup) - Attenuates the Mammary Tumor Induction Magnitude of 7,12-Dimethylbenz[a] anthracene in Sprague–Dawley Rats

2020 ◽  
Vol 16 (5) ◽  
pp. 467
Author(s):  
MuthuKumaradoss Mohanmarugaraja ◽  
Agilandeswari Devarajan ◽  
MuthuKumaradoss Kathiravan
Keyword(s):  
Mammary Tumor ◽  
Sprague Dawley ◽  
Tumor Induction ◽  
South Indian ◽  
Sprague Dawley Rats

scholarly journals Potency of Murraya koenigii Leaves as Anti-Cancer Mammary in 7,12 dimethylbenz(α) anthracene (DMBA) induced-Sprague Dawley Rats

2020 ◽  
Vol 151 ◽  
pp. 01058
Author(s):  
Siti Aisyah ◽  
Ekowati Handharyani ◽  
Nurliani Bermawie ◽  
Agus Setiyono
Keyword(s):  
Mammary Tumor ◽  
Tumor Size ◽  
Histopathological Examination ◽  
Tumor Development ◽  
Collagen Fibers ◽  
Female Rats ◽  
Sprague Dawley ◽  
Murraya Koenigii ◽  
Sprague Dawley Rat ◽  
Sprague Dawley Rats

The purpose of the research was to study the potency of Murraya koenigii leaves extract to overcome the mammary tumor in Sprague Dawley rat. Thirty-five female rats were divided into seven groups: control (P1), tumor without therapy (P2), methotrexate group (P3), curative groups (P4 and P5) were given extract after the tumor was formed, and preventive groups (P6 and P7) were given extract before the tumor was formed with dose of 300 and 400 mg/kg, respectively. The induction of mammary tumor in rats were carried out using 7,12 dimethylbenz(α) anthracene (DMBA) subcutaneously. Bodyweight and tumor size were measured every week for 4 weeks. At the end of treatment, rats were euthanized and mammary glands were collected for histopathological examination. The result showed tumor size in P2 was significantly higher (p<0.05) than in other groups. On the other hand, tumor size in P4 and P6 were significantly smaller (p<0.05) compared to P5 and P7. Histopathological changes showed PMN cells, 1-3 layers of cuboid epithelial and solid collagen fibers proliferation in P2, while in P3 to P7 showed moderate collagen fibers proliferation. In conclusion, the administration of the extract at a dose of 300 mg/kg can decelerate tumor development in Sprague Dawley rat mammary gland.

Mammary and renal tumor induction by low doses of adriamycin in Sprague-Dawley rats

1987 ◽  
Vol 8 (8) ◽  
pp. 1149-1153 ◽  
Author(s):  
J.J. Jang ◽  
M. Takahashi ◽  
R. Hasegawa ◽  
F. Furukawa ◽  
K. Toyoda ◽  
...  
Keyword(s):  
Renal Tumor ◽  
Low Doses ◽  
Sprague Dawley ◽  
Tumor Induction ◽  
Sprague Dawley Rats

scholarly journals Effect of Vitex agnus Extract on MNU Induced Mammary Tumor of Sprague Dawley Rats

2017 ◽  
Vol 9 (3) ◽  
pp. 367-370 ◽  
Author(s):  
Maninder Kour ◽  
Vinodini Nithyananda Madom Anantharaya ◽  
Kumar Megur Ramakrishna Bhat ◽  
Shrijeet Chakraborti ◽  
Bhagyalakshmi Kodavanji
Keyword(s):  
Mammary Tumor ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Prevention of Mammary Tumor Development through Neuroimmunomodulation in the Spleen and Lymph Nodes of Old Female Sprague-Dawley Rats by L-Deprenyl

2013 ◽  
Vol 20 (3) ◽  
pp. 141-151 ◽  
Author(s):  
Srinivasan ThyagaRajan ◽  
Lily Tran ◽  
Christine A. Molinaro ◽  
Daila S. Gridley ◽  
David L. Felten ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Mammary Tumor ◽  
Tumor Development ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Spleen And Lymph Nodes

The Effect of N-Methyl-N-Nitrosourea (MNU) and Dimethylbenzanthracene (DMBA) in Developing the Mammary Tumor in Wistar Albino and Sprague Dawley Rats-A Comparative Study

2017 ◽  
Vol 23 (3) ◽  
pp. 1758-1762
Author(s):  
Maninder Kour ◽  
N. A Vinodini ◽  
Kumar M. R Bhat ◽  
Shrijeet Chakraborti ◽  
A. K Nayanatara
Keyword(s):  
Comparative Study ◽  
Mammary Tumor ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

In vivo anti-tumor efficacy of Croton oblongifolius in DMBA induced mammary tumor in rats

2017 ◽  
Author(s):  
Gowrav Adiga P. ◽  
N. B. Shridhar ◽  
Jagadeesh S. Sanganal ◽  
Suguna Rao ◽  
N. Shilpa ◽  
...  
Keyword(s):  
Mammary Tumor ◽  
Stem Bark ◽  
Dependent Manner ◽  
Sprague Dawley ◽  
Treatment Groups ◽  
Sprague Dawley Rats ◽  
Croton Oblongifolius ◽  
Anti Tumor Activity ◽  
Dose Dependent

The present study was designed to evaluate anti-tumor activity of the methanolic extract of stem bark of Croton oblongifolius in Sprague Dawley rats. The tumor was induced in rats by DMBA given orally and intramammarily and challenging with plant extract. After obtaining suitable mass of tumor, the extract was gavaged to rats @ 200, 500 and 800 mg/kg which showed reduction in mammary tumor volume in dose-dependent manner, which was supported by histopathological observations of the treatment groups.

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