Blood chemistry profiles of DMBA-induced mammary tumor in female sprague dawley rats

2019 ◽  
Author(s):  
Padlianah ◽  
Mutmainnah Arif ◽  
Ika Yustisia
Keyword(s):  
Mammary Tumor ◽  
Blood Chemistry ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Rasam (South Indian Spice Soup) - Attenuates the Mammary Tumor Induction Magnitude of 7,12-Dimethylbenz[a] anthracene in Sprague–Dawley Rats

2020 ◽  
Vol 16 (5) ◽  
pp. 467
Author(s):  
MuthuKumaradoss Mohanmarugaraja ◽  
Agilandeswari Devarajan ◽  
MuthuKumaradoss Kathiravan
Keyword(s):  
Mammary Tumor ◽  
Sprague Dawley ◽  
Tumor Induction ◽  
South Indian ◽  
Sprague Dawley Rats

scholarly journals Potency of Murraya koenigii Leaves as Anti-Cancer Mammary in 7,12 dimethylbenz(α) anthracene (DMBA) induced-Sprague Dawley Rats

2020 ◽  
Vol 151 ◽  
pp. 01058
Author(s):  
Siti Aisyah ◽  
Ekowati Handharyani ◽  
Nurliani Bermawie ◽  
Agus Setiyono
Keyword(s):  
Mammary Tumor ◽  
Tumor Size ◽  
Histopathological Examination ◽  
Tumor Development ◽  
Collagen Fibers ◽  
Female Rats ◽  
Sprague Dawley ◽  
Murraya Koenigii ◽  
Sprague Dawley Rat ◽  
Sprague Dawley Rats

The purpose of the research was to study the potency of Murraya koenigii leaves extract to overcome the mammary tumor in Sprague Dawley rat. Thirty-five female rats were divided into seven groups: control (P1), tumor without therapy (P2), methotrexate group (P3), curative groups (P4 and P5) were given extract after the tumor was formed, and preventive groups (P6 and P7) were given extract before the tumor was formed with dose of 300 and 400 mg/kg, respectively. The induction of mammary tumor in rats were carried out using 7,12 dimethylbenz(α) anthracene (DMBA) subcutaneously. Bodyweight and tumor size were measured every week for 4 weeks. At the end of treatment, rats were euthanized and mammary glands were collected for histopathological examination. The result showed tumor size in P2 was significantly higher (p<0.05) than in other groups. On the other hand, tumor size in P4 and P6 were significantly smaller (p<0.05) compared to P5 and P7. Histopathological changes showed PMN cells, 1-3 layers of cuboid epithelial and solid collagen fibers proliferation in P2, while in P3 to P7 showed moderate collagen fibers proliferation. In conclusion, the administration of the extract at a dose of 300 mg/kg can decelerate tumor development in Sprague Dawley rat mammary gland.

scholarly journals Effect of Vitex agnus Extract on MNU Induced Mammary Tumor of Sprague Dawley Rats

2017 ◽  
Vol 9 (3) ◽  
pp. 367-370 ◽  
Author(s):  
Maninder Kour ◽  
Vinodini Nithyananda Madom Anantharaya ◽  
Kumar Megur Ramakrishna Bhat ◽  
Shrijeet Chakraborti ◽  
Bhagyalakshmi Kodavanji
Keyword(s):  
Mammary Tumor ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Ninety-Day Toxicity Study of Alpha-Iso-Methylionone in Rats

2012 ◽  
Vol 31 (6) ◽  
pp. 595-601 ◽  
Author(s):  
Valerie T. Politano ◽  
Aurelia A. Lapczynski ◽  
Gretchen Ritacco ◽  
Anne Marie Api
Keyword(s):  
Blood Chemistry ◽  
Tubular Epithelium ◽  
Histopathological Changes ◽  
Sprague Dawley ◽  
Renal Tubular Epithelium ◽  
Sprague Dawley Rats ◽  
Adverse Effect Level ◽  
Liver And Kidney ◽  
Effect Level ◽  
Renal Tubular

Alpha-iso-methylionone (AIM), a fragrance ingredient, was evaluated for systemic toxicity in rats. Male and female Sprague Dawley rats were administered 0, 5, 30, or 500 mg/kg/d AIM via gavage for 90 days. Statistically significant changes in blood chemistry parameters (reduced aspartate aminotransferase [AST], and increased cholesterol, creatinine, and total protein) were observed in both sexes at 500 mg/kg/d. There were statistically significant increases in liver and kidney weights in both sexes and in spleen weights in males at 500 mg/kg/d. Adaptive hepatocyte enlargement was observed in both sexes at 500 mg/kg/d. Globular accumulations of eosinophilic material were observed in the renal tubular epithelium in males at ≥30 mg/kg/d. Thyroid and bone marrow histopathological changes were observed in males at 500 mg/kg/d. The no-observed-effect level was 5 mg/kg/d for males and 30 mg/kg/d for females. Based on histopathological changes in the kidney in males, the no-observed-adverse-effect level was 30 mg/kg/d.

Prevention of Mammary Tumor Development through Neuroimmunomodulation in the Spleen and Lymph Nodes of Old Female Sprague-Dawley Rats by L-Deprenyl

2013 ◽  
Vol 20 (3) ◽  
pp. 141-151 ◽  
Author(s):  
Srinivasan ThyagaRajan ◽  
Lily Tran ◽  
Christine A. Molinaro ◽  
Daila S. Gridley ◽  
David L. Felten ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Mammary Tumor ◽  
Tumor Development ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Spleen And Lymph Nodes

scholarly journals UJI TOKSIK SUSPENSI SEL PUNCA CD34+ MANUSIA PADA TIKUS SPRAGUE DAWLEY (SD)

2019 ◽  
Vol 8 (2) ◽  
Author(s):  
Basuki Supartono
Keyword(s):  
Cord Blood ◽  
Good Condition ◽  
Blood Chemistry ◽  
Sprague Dawley ◽  
Human Cord Blood ◽  
Rejection Reaction ◽  
Hematopoietic Stem ◽  
Sprague Dawley Rats ◽  
Cd34 Cells ◽  
Cord Blood Cd34

Introduction :  Research of CD34+ cells intervention to rats is not yet done. This researchis the latest research which investigated the toxic reaction of CD34+ hematopoietic stem cell intervention in non engineered rats.Methods : 3 Sprague Dawley rats, male, 7 months, 285+18,5 g. Rat 1 : received intraartricular injection of human peripheral blood CD34+ cells (105 cells). Rat 2 : received intraartricular injection of human cord blood CD34+ cells (105 cells). Rat 3 : received intraartricular injection of human cord blood CD34+ cells (106 cells), hyaluronic acid and grown factors. All rats were examined hematological, blood chemistry parameters and microscopic of the liver and kidney.Result : All rats showed good condition. There is slight increasing parameter in hematological and blood chemistry but liver and kidney in normal microscopic condition. No hiperacute rejection reaction : edema, systemic bleeding. There is no hyper acute and acute reaction.Conclusion :  Human CD34+ cells suspension with or without scaffold and growth factors does not cause toxicity reaction in naïve Sprague Dawley rats. 

scholarly journals Toxicity Sub chronic Water Extract Meretrix meretrix Linnaeus In Vivo on Sprague dawley Rats

2016 ◽  
Vol 19 (2) ◽  
pp. 177 ◽  
Author(s):  
Azwin Apriandi ◽  
Kustiariyah Tarman ◽  
Purwantiningsih Sugita
Keyword(s):  
Feed Intake ◽  
Sea Water ◽  
Water Extract ◽  
Blood Chemistry ◽  
Meretrix Meretrix ◽  
Sprague Dawley ◽  
Normal Category ◽  
Sprague Dawley Rats ◽  
Liver And Kidney

Meretrix meretrix is one of the shells of sea water are widely utilized by people as food. This clam<br />also has many properties and benefits, so in this study tested the effect of the water extract of Meretrix<br />meretrix against blood chemistry profile Sprague Dawley rats with the method (OECD 413: 2009). Based on<br />observations obtained growth, feed intake, weight of liver and kidney in normal conditions. Levels of urea,<br />creatinine, cholesterol between the control mice treated with A/0.1 and A/1 were not significantly different<br />(p&gt; 0.05) while the levels of bilirubin and albumin between control mice treated with A/0.1 and A/1 results<br />significantly different (p&lt;0.05), but all blood chemistry parameters tested is still in the normal category.<br /><br />

scholarly journals Hypolipidemic and Hypoglycaemic Effect of Wholemeal Bread with Amaranth (Amaranthus dubius Mart. ex Thell.) on Sprague Dawley Rats

Foods ◽  
2020 ◽  
Vol 9 (6) ◽  
pp. 707 ◽  
Author(s):  
Adriana Beatriz Sánchez-Urdaneta ◽  
Keyla Carolina Montero-Quintero ◽  
Pedro González-Redondo ◽  
Edgar Molina ◽  
Belkys Bracho-Bravo ◽  
...  
Keyword(s):  
Blood Lipids ◽  
Total Cholesterol Level ◽  
Risk Index ◽  
Density Lipoprotein ◽  
Blood Chemistry ◽  
Lipoprotein Cholesterol ◽  
Abdominal Circumference ◽  
Elevated Blood ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

The effect of consuming breads made with wheat flour and Amaranth (Amaranthus dubius Mart. ex Thell.) wholemeal flour on Sprague Dawley rats with hyperlipidaemia and hyperglycaemia induced through feeding was studied. Four diets were provided: control (CD: Ratarina®), commercial bread (CBD), bread with 100 g·kg−1 (ABD10) and 200 g·kg−1 (ABD20) amaranth flour. Zoometric and blood chemistry parameters were measured before and after consuming the diets. A completely random factorial design of 2 × 4 × 2 was used. The factors were blood lipids and glucose level (normal, N and elevated, E), diet (CD, CBD, ABD10 and ABD20) and sex (female, F and male, M). The rats consuming ABD10 and ABD20 diets presented the lowest glucose values, although with no differences (p > 0.05) between the groups of elevated blood lipids and glucose rats (E). Triglyceride concentrations decreased in ABD10 and ABD20 treatments in comparison with CD, elevated blood lipids and glucose (E) rats, while ABD10 rats showed lower total cholesterol level than normal (N) rats. The high-density lipoprotein cholesterol values increased in the ABD10 and ABD20 groups (p < 0.05), while it did lower for very low-density lipoprotein cholesterol and cardiac risk index (p < 0.05). In ABD10 and ABD20 treatments, the abdominal circumference decreased in both sexes (p < 0.05) between weeks 23 and 31. In conclusion, consumption of bread with amaranth improved lipid profiles of rats and could help to prevent metabolic and cardiovascular diseases.

Sign in / Sign up

Export Citation Format

Share Document