Acral subcorneal hematoma: Additional dermoscopic findings differentiating it from acral melanocytic lesions

2021 ◽  
Vol 25 (1) ◽  
pp. 18
Author(s):  
AhmedH Nassar ◽  
AbdullahS Abu-Aliat ◽  
SohaA Hawwam
Keyword(s):  
Melanocytic Lesions

Association of HERV-K and LINE-1 hypomethylation with reduced disease-free survival in melanoma patients

Epigenomics ◽  
2020 ◽  
Vol 12 (19) ◽  
pp. 1689-1706
Author(s):  
Maurizio Cardelli ◽  
Remco van Doorn ◽  
Lares Larcher ◽  
Michela Di Donato ◽  
Francesco Piacenza ◽  
...  
Keyword(s):  
Independent Predictor ◽  
Disease Free Survival ◽  
Endogenous Retrovirus ◽  
Human Endogenous Retrovirus ◽  
Free Survival ◽  
Melanocytic Lesions ◽  
Long Interspersed Nuclear Elements ◽  
Melanoma Patients ◽  
And Gender ◽  
Disease Free

Aim: To evaluate CpG methylation of long interspersed nuclear elements 1 (LINE-1) and human endogenous retrovirus K (HERV-K) retroelements as potential prognostic biomarkers in cutaneous melanoma. Materials & methods: Methylation of HERV-K and LINE-1 retroelements was assessed in resected melanoma tissues from 82 patients ranging in age from 14 to 88 years. In addition, nevi from eight patients were included for comparison with nonmalignant melanocytic lesions. Results: Methylation levels were lower in melanomas than in nevi. HERV-K and LINE-1 methylation were decreased in melanoma patients with clinical parameters associated with adverse prognosis, while they were independent of age and gender. Hypomethylation of HERV-K (but not LINE-1) was an independent predictor of reduced disease-free survival. Conclusion: HERV-K hypomethylation can be a potential independent biomarker of melanoma recurrence.

scholarly journals Femtosecond laser‐assisted excision of conjunctival melanocytic lesions: Cosmetic and long‐term outcomes

2021 ◽  
Author(s):  
Victoria Grace Dimacali ◽  
Yu‐Chi Liu ◽  
Hon Shing Ong ◽  
Darren S. J. Ting ◽  
Jodhbir S. Mehta
Keyword(s):  
Femtosecond Laser ◽  
Long Term Outcomes ◽  
Melanocytic Lesions

scholarly journals Genome-wide copy number variations as molecular diagnostic tool for cutaneous intermediate melanocytic lesions: a systematic review and individual patient data meta-analysis

2021 ◽  
Author(s):  
Chiel F. Ebbelaar ◽  
Anne M. L. Jansen ◽  
Lourens T. Bloem ◽  
Willeke A. M. Blokx
Keyword(s):  
Systematic Review ◽  
Sensitivity And Specificity ◽  
Copy Number ◽  
Individual Patient Data ◽  
Meta Analysis ◽  
Copy Number Variations ◽  
Patient Data ◽  
Melanocytic Lesions ◽  
Genome Wide ◽  
Malignant Lesions

AbstractCutaneous intermediate melanocytic neoplasms with ambiguous histopathological features are diagnostically challenging. Ancillary cytogenetic techniques to detect genome-wide copy number variations (CNVs) might provide a valuable tool to allow accurate classification as benign (nevus) or malignant (melanoma). However, the CNV cut-off value to distinguish intermediate lesions from melanoma is not well defined. We performed a systematic review and individual patient data meta-analysis to evaluate the use of CNVs to classify intermediate melanocytic lesions. A total of 31 studies and 431 individual lesions were included. The CNV number in intermediate lesions (median 1, interquartile range [IQR] 0–2) was significantly higher (p<0.001) compared to that in benign lesions (median 0, IQR 0–1) and lower (p<0.001) compared to that in malignant lesions (median 6, IQR 4–11). The CNV number displayed excellent ability to differentiate between intermediate and malignant lesions (0.90, 95% CI 0.86–0.94, p<0.001). Two CNV cut-off points demonstrated a sensitivity and specificity higher than 80%. A cut-off of ≥3 CNVs corresponded to 85% sensitivity and 84% specificity, and a cut-off of ≥4 CNVs corresponded to 81% sensitivity and 91% specificity, respectively. This individual patient data meta-analysis provides a comprehensive overview of CNVs in cutaneous intermediate melanocytic lesions, based on the largest pooled cohort of ambiguous melanocytic neoplasms to date. Our meta-analysis suggests that a cut-off of ≥3 CNVs might represent the optimal trade-off between sensitivity and specificity in clinical practice to differentiate intermediate lesions from melanoma.

A prospective, comprehensive registry that integrates the molecular analysis of pediatric and adolescent melanocytic lesions

Cancer ◽  
2021 ◽  
Author(s):  
Alberto S. Pappo ◽  
Valerie McPherson ◽  
Haitao Pan ◽  
Fang Wang ◽  
Lu Wang ◽  
...  
Keyword(s):  
Molecular Analysis ◽  
Melanocytic Lesions ◽  
Comprehensive Registry

Survival in small choroidal melanocytic lesions with risk factors managed by initial observation until detection of tumour growth

2021 ◽  
Vol 49 (3) ◽  
pp. 251-259
Author(s):  
Laura Vigués‐Jorba ◽  
Rahul Morwani ◽  
Daniel Lorenzo ◽  
Maria C. Baradad‐Jurjo ◽  
Luis Arias ◽  
...  
Keyword(s):  
Risk Factors ◽  
Tumour Growth ◽  
Initial Observation ◽  
Melanocytic Lesions
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