The The COmprehensive Registry and rEsearch on Heart Failure (CORE-HF) : 2 years report from single-center Indonesian heart failure clinic registry

Introduction: Heart failure (HF) remains a rising global epidemic which lacking population-based data, especially in Indonesia. The COmprehensive Registry and rEsearch on Heart Failure (CORE-HF) is a single-center registry of Sebelas Maret HF Clinic as part of the ongoing national HF registry under InaHF. This paper designed to give an overview of HF epidemiological data, thus improves HF service quality, especially at Surakarta region. Methods: The CORE-HF is a cohort, prospective, single-center registry which enrolls all patients with chronic HF. Subjects were recruited consecutively from the outpatient clinic of Sebelas Maret HF Clinic at UNS Academic Hospital. Both enrollment and follow-up have been performed since January 2018 until present. Variables recorded consist of basic characteristics, baseline risk factors, subjective indicators, objective diagnostic assessments, pharmacological therapy, and outcome indicators. Results: HFrEF has a significant association towards a higher number of rehospitalization and all-cause mortality at any time (p<0.001). The 12 and 24-months cardiac related rehospitalization occurred significantly more in HFrEF group compared to other groups (p<0.001), whereas rehospitalization in HFpEF dominated by non-cardiac cause (p=0.381). Cumulative all cause mortality is significantly highest in HFrEF group for any period of time (p<0.001). Conclusion: As a part of InaHF National HF registry, the CORE-HF registry focuses in chronic HF and designed to give an overview of HF epidemiological data, especially at Surakarta region. Together with HF Clinic system, we assure not only the optimal GDMT for all indicative patients, but also patient’s compliance.

Comparison of the effects of radiotherapy doses of 50.4 Gy and 60 Gy on outcomes of chemoradiotherapy for thoracic esophageal cancer: subgroup analysis based on the Comprehensive Registry of Esophageal Cancer in Japan from 2009 to 2011 by the Japan Esophageal Society

Background In definitive chemoradiotherapy (CRTx) for esophageal cancer, a radiotherapy (RT) dose of 50.4 Gy in 28 fractions has been the standard in many countries, while 60 Gy in 30 fractions has been frequently used in Japan. To clarify the optimal RT dose in CRTx for esophageal cancer, we compared clinical outcomes with the two doses using data from the Comprehensive Registry of Esophageal Cancer in Japan by the Japan Esophageal Society (JES). Methods Of the patients enrolled in the registry for 2015–2017 surveys (patients treated between 2009 and 2011), 996 patients who received definitive CRTx with 50.4 Gy or 60 Gy for thoracic esophageal cancer were eligible for analysis. Results The complete response (CR) rates in the 50.4 Gy and 60 Gy groups were 49.1% and 46.4%, respectively (p = 0.5851). The 5-year overall survival (OS) rates in the 50.4 Gy group and 60 Gy group for stages I, II/III and IV were 64.2% and 57.2%, 35.0% and 27.0%, and 18.0% and 15.3%, respectively. Since no significant difference was found between the two groups, the 50.4 Gy group was not inferior to the 60 Gy group with regard to OS. Conclusions The analysis revealed that the 50.4 Gy group had a non-inferior outcome in comparison with the 60 Gy group for stages I, II/III and IV thoracic esophageal cancer. These results were obtained from a large database for the first time in Japan.

Community curation of bioinformatics software and data resources

The corpus of bioinformatics resources is huge and expanding rapidly, presenting life scientists with a growing challenge in selecting tools that fit the desired purpose. To address this, the European Infrastructure for Biological Information is supporting a systematic approach towards a comprehensive registry of tools and databases for all domains of bioinformatics, provided under a single portal (https://bio.tools). We describe here the practical means by which scientific communities, including individual developers and projects, through major service providers and research infrastructures, can describe their own bioinformatics resources and share these via bio.tools.