scholarly journals Melanocytic lesions with peripheral globules: still a pitfall in the differential diagnosis of melanoma

2021 ◽  
Vol 35 (5) ◽  
pp. 1040-1040
Author(s):  
E. Lazaridou ◽  
C. Fotiadou ◽  
Z. Apalla
Keyword(s):  
Differential Diagnosis ◽  
Melanocytic Lesions

scholarly journals Primary pineal malignant melanoma

2011 ◽  
Vol 1 (2) ◽  
pp. 31 ◽  
Author(s):  
Oderay Mabel Cedeño Díaz ◽  
Roberto Garcia Leal ◽  
Cesar La Cruz Pelea
Keyword(s):  
Differential Diagnosis ◽  
Radiation Therapy ◽  
Malignant Melanoma ◽  
World Literature ◽  
Rare Entity ◽  
Rare Tumour ◽  
Melanocytic Lesions ◽  
The World ◽  
Supracerebellar Infratentorial Approach ◽  
Visual Abnormalities

Primary pineal malignant melanoma is a rare entity, with only thirteen cases reported in the world literature to date. We report a case of a 70-year-old man, who consulted with gait disturbance of six months duration, associated in the last month with dizziness, visual abnormalities and diplopia. No other additional melanocytic lesions were found elsewhere. The magnetic resonance showed a 25 mm expansive mass in the pineal gland that was associated with hydrocephaly, ventricular and transependimary oedema. The lesion was partially excised by a supracerebellar infratentorial approach. The histological examination revealed a melanoma. The patient received radiation therapy, but died of disease 16 weeks later. We herein review the literature on this rare tumour and comment on its clinical, radiological and histopathological features and differential diagnosis.

Differential diagnosis of heavily pigmented melanocytic lesions: challenges and diagnostic approach

2015 ◽  
Vol 68 (12) ◽  
pp. 963-970 ◽  
Author(s):  
Phyu P Aung ◽  
Kudakwashe K Mutyambizi ◽  
Richard Danialan ◽  
Doina Ivan ◽  
Victor G Prieto
Keyword(s):  
Differential Diagnosis ◽  
Spindle Cell ◽  
Carney Complex ◽  
Melanin Pigment ◽  
Lymphocytic Infiltrate ◽  
Histological Features ◽  
Pigmented Lesion ◽  
Melanocytic Lesions ◽  
Blue Naevus ◽  
Mitotic Figures

The differential diagnosis of heavily pigmented melanocytic neoplasms includes melanoma (especially animal type), melanosis of partially or completely regressed melanoma, blue naevus (BN), pigmented Spitzoid lesions, recurrent naevus, combined naevus, pigmented spindle cell naevus, epithelioid blue naevus of the Carney complex/pigmented epithelioid melanocytoma, deep penetrating naevus, hyperpigmented scar after surgery of melanoma in which there are also melanophages and hyperpigmentation due to the minocycline, a tattoo or a hyperpigmented scar. Pathologists face challenges when evaluating a pigmented lesion, especially in a small superficial biopsy, because it is difficult to access important histopathological features to differentiate benign versus malignant melanocytic lesions. The histological features that favour a diagnosis of melanoma include dimension (>6 mm), asymmetry, poor circumscription, irregular confluent nests, confluent lentiginous junctional melanocytic proliferation, lack of maturation with descent in the dermis, suprabasal pagetoid melanocytes, asymmetrical distribution of melanin pigment, cytological atypia, dermal mitotic figures, asymmetrical dermal lymphocytic infiltrate and necrosis.

Animal-type melanoma: dog or wolf? A review of the literature and a case report

2018 ◽  
Vol 20 ◽  
Author(s):  
Luigia Stefania Stucci ◽  
Raffaele Palmirotta ◽  
Domenica Lovero ◽  
Erica Silvestris ◽  
Paola Cafforio ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Scientific Literature ◽  
Current Knowledge ◽  
Molecular Data ◽  
The Other ◽  
Review Of The Literature ◽  
Biological Behaviour ◽  
Melanocytic Lesions ◽  
Human Animal

AbstractThe human animal type melanoma (ATM) is a rare subtype of melanoma characterised by the proliferation of pigmented dermal epithelioid and spindled melanocytes. However, this variant of melanoma is still lacking a precise nosography definition and classification for the difficulty to be distinguished from other more common melanocytic lesions, as well as for its peculiar biological behaviour. On the other hand, the contribution of scientific literature to this issue is fragmented and limited to the description of very few cases. Starting from the presentation of a case with abnormally aggressive clinical features, here we revisit the current knowledge on ATM from its dermatologic patterns, epidemiology, demography and histopathology to the clinical management. Peculiar accuracy has also been reserved to several histopathologic criteria, which are critical for the differential diagnosis from other melanocytic diseases in junction with molecular data deriving from recent cytogenetic and mutational characterisation of this tumour.

scholarly journals Early diagnosis of melanoma by surface microscopy (dermatoscopy)

1996 ◽  
Vol 114 (4) ◽  
pp. 1220-1221 ◽  
Author(s):  
Francisco Macedo Paschoal
Keyword(s):  
Differential Diagnosis ◽  
Early Diagnosis ◽  
Simple Technique ◽  
Skin Lesions ◽  
Accurate Diagnosis ◽  
Diagnostic Sensitivity ◽  
Melanocytic Lesions ◽  
Surface Microscopy ◽  
Pigmented Skin Lesions

The main objective of surface microscopy is the early and accurate diagnosis of melanoma in its initial phases of evolution and infiltration. Since the development of the dermatoscope in the 1990's, surface microscopy has become a simple technique. Differential diagnosis of pigmented skin lesions can be achieved with a diagnostic sensitivity of about 90 percent, and the proper differentiation of pigmented melanocytic and non-melanocytic lesions, and malignant and benign melanocytic lesions, may also be safely determined.

scholarly journals Artificial Intelligence in Dermatopathology: New Insights and Perspectives

2021 ◽  
Vol 8 (3) ◽  
pp. 418-425
Author(s):  
Gerardo Cazzato ◽  
Anna Colagrande ◽  
Antonietta Cimmino ◽  
Francesca Arezzo ◽  
Vera Loizzi ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Machine Learning ◽  
Differential Diagnosis ◽  
State Of The Art ◽  
The State ◽  
Embryonic Stage ◽  
Future Perspectives ◽  
Review Of The Literature ◽  
Melanocytic Lesions ◽  
Modern Era

In recent years, an increasing enthusiasm has been observed towards artificial intelligence and machine learning, involving different areas of medicine. Among these, although still in the embryonic stage, the dermatopathological field has also been partially involved, with the attempt to develop and train algorithms that could assist the pathologist in the differential diagnosis of complex melanocytic lesions. In this article, we face this new challenge of the modern era, carry out a review of the literature regarding the state of the art and try to determine promising future perspectives.

Dermoscopy in Pigmented Squamous Cell Carcinoma

2009 ◽  
Vol 13 (6) ◽  
pp. 326-329 ◽  
Author(s):  
Vincenzo de Giorgi ◽  
Barbara Alfaioli ◽  
Federica Papi ◽  
Agata Janowska ◽  
Marta Grazzini ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Differential Diagnosis ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Potential Role ◽  
Diagnostic Errors ◽  
Skin Lesions ◽  
Melanocytic Lesion ◽  
Melanocytic Lesions ◽  
Pigmented Skin Lesions

Background: The diagnosis of squamous cell carcinoma (SCC) is, generally, a clinical diagnosis, but in some cases, when the lesion is pigmented, as in our case, the differential diagnosis between pigmented SCC and other pigmented skin lesions, in particular melanocytic lesions, is difficult. Dermoscopy may improve the early diagnosis of SCC and thus play a role in its preoperative classification. However, its potential role has been hampered so far by the fact that little is known about the dermoscopic features of pigmented SCC. Objective: We report the case of a rare pigmented SCC dermoscopically mimicking a melanocytic lesion whose dermoscopic features have been investigated. Conclusion: On the basis of the literature and our experience, pigmented SCC can present dermoscopic features typical of melanocytic lesions, such as radial streaks, globules, and homogeneous blue pigmentation, and can lead dermatologists to diagnostic errors.

scholarly journals Melanocytic or Not? Dermoscopy and Reflectance Confocal Microscopy for Lesions Difficult to Diagnose: A Cross-Sectional Diagnostic Accuracy Study

2021 ◽  
pp. e2021127
Author(s):  
Camila Scharf ◽  
Giuseppe Argenziano ◽  
Gabriella Brancaccio ◽  
Gaetano Licata ◽  
Andrea Ronchi ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Confocal Microscopy ◽  
Diagnostic Accuracy ◽  
High Specificity ◽  
Skin Lesions ◽  
Reflectance Confocal Microscopy ◽  
Melanocytic Lesion ◽  
Cross Sectional ◽  
Present Sample ◽  
Melanocytic Lesions

Background: Different techniques for non-invasive skin examination and early diagnosis of skin lesions are available nowadays, being dermoscopy and reflectance confocal microscopy (RCM) the most diffused ones. Several studies supported the complementary use of dermoscopy and RCM that improves diagnostic accuracy when dealing with melanocytic lesions. Objectives: To analyze RCM diagnostic accuracy in the differential diagnosis between melanocytic and non-melanocytic lesions. Methods: This is a cohort selected cross-sectional study conducted at the Dermatology Unit of the University of Campania L. Vanvitelli, Naples, Italy, from 2012 to 2020. We searched the image database for all excised lesions for which the clinical and dermatoscopic differential diagnosis was between melanocytic and non-melanocytic and for which an RCM examination was performed. Sensitivity, specificity, and diagnostic accuracy values ​​were estimated. Results: The study included 53 cases that were found to have disagreement between clinical, histological and RCM diagnosis, of which, in 31 cases the differential diagnosis was melanocytic vs non-melanocytic lesion. The RCM reached a specificity of 87% (95% CI: 0.73-1) and a sensitivity of 62.5% (95% CI: 0.29-0.96) in the present sample. Diagnostic accuracy was 80.6% (95% CI: 0.67-0.94). Conclusion: RCM has a high specificity in differentiating between difficult-to-diagnose melanocytic and non-melanocytic lesions.

scholarly journals Melanotic Macule in Conjunction with a Giant Cell Fibroma

2017 ◽  
Vol 18 (10) ◽  
pp. 981-985
Author(s):  
Samantha D Seitz ◽  
Thanhphuong N Dinh ◽  
Thomas YH Yoon
Keyword(s):  
Differential Diagnosis ◽  
Giant Cell ◽  
Oral Mucosa ◽  
Clinical History ◽  
Pyogenic Granuloma ◽  
Final Diagnosis ◽  
Etiologic Factor ◽  
Pigmented Lesions ◽  
Melanocytic Lesions ◽  
Histologic Evaluation

ABSTRACT Introduction The aim of this study is to describe a case of a melanotic macule found in conjunction with a giant cell fibroma (GCF). For oral pigmented lesions without an identifiable etiologic factor, critical factors in determining the differential diagnosis are clinical history, symmetry, and uniformity of the lesions. Potential differential diagnosis includes racial pigmentation, endocrine disturbance, Peutz–Jeghers syndrome, trauma, hemochromatosis, oral malignant melanoma, or idiopathic etiology and melanotic macules. Melanotic macules are the most common solitary pigmented melanocytic lesions in the oral mucosa, corresponding to 86.1% of melanocytic lesions of the mouth. Giant cell fibromas are reactive connective tissue lesions in the oral cavity. They were first described as a distinct entity in 1974 by Weathers and Callihan and make up around 5 to 10% of all oral mucosa fibrous lesions. They are commonly mistaken for other growths, such as pyogenic granuloma and fibroma, and diagnosis is accurately based on its distinctive histopathology. This article presents the clinicopathologic findings of a 15-year-old Hispanic male presenting for biopsy of a melanotic macule on the mandibular anterior buccal gingiva. Histologic evaluation of the specimen revealed that the lesion also contained a GCF. Pathologic lesions of the mouth should be carefully diagnosed. Conventionally, histologic evaluation is the gold standard to produce a final diagnosis. As evidenced in this article, multiple lesions may exist in a site and may be mistakenly diagnosed as a single entity. Clinical significance While each lesion has been reported individually, in reviewing the literature, no cases were reported in which both histopathologic findings of GCF and melanotic macule were present within the same lesion. How to cite this article Seitz SD, Dinh TN, Yoon TYH. Melanotic Macule in Conjunction with a Giant Cell Fibroma. J Contemp Dent Pract 2017;18(10):981-985.

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