scholarly journals “Vitamin D” as a profile marker for cardiovascular diseases

2019 ◽  
Vol 22 (1) ◽  
pp. 47 ◽  
Author(s):  
Deepak Oberoi ◽  
Vinit Mehrotra ◽  
Anurag Rawat
Keyword(s):  
Vitamin D ◽  
Cardiovascular Diseases

scholarly journals The Impact of Micronutrients-Calcium, Vitamin D, Selenium, Zinc in Cardiovascular Health: A Mini Review

2021 ◽  
Vol 12 ◽  
Author(s):  
Harini Narayanam ◽  
Suresh V. Chinni ◽  
Sumitha Samuggam
Keyword(s):  
Vitamin D ◽  
Trace Elements ◽  
Cardiovascular Diseases ◽  
Observational Studies ◽  
Cardiovascular Health ◽  
Main Concern ◽  
Sudden Increase ◽  
Cardiac Health ◽  
Health And Disease ◽  
The Impact

The role of micronutrients in health and disease has increased the curiosity and interest among researchers. The prime focus of this review is the significance of trace elements- calcium, vitamin D, selenium and zinc with cardiovascular health. WHO identified cardiovascular diseases (CVD) as the leading cause of deaths globally. Identifying the risk factors that could be modified and creating new treatment strategies remains to be the main concern for CVD prevention. The data that showed the relationship between trace elements and various ways in which they may contribute to cardiovascular health and disease from clinical trials and observational studies were collected from databases such as PubMed and Embase. Based on these collected data, it shows that either high or low circulating serum levels can be associated with the development of cardiovascular diseases. Micronutrients through diet contribute to improved cardiac health. However, due to our current lifestyle, there is a huge dependency on dietary supplements. Based on the observational studies, it is evident that supplements cause sudden increase in the circulating levels of the nutrients and result in cardiovascular damage. Thus, it is advisable to restrict the use of supplements, owing to the potent risks it may cause. In order to understand the exact mechanism between micronutrients and cardiac health, more clinical studies are required.

scholarly journals Relationship Between Advanced Glycation End Products and Their Receptor, sRAGE and Cardiovascular Diseases Risk in Adults with T2D and Vitamin D Insufficiency/deficiency (FS12-08-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Justina Owusu ◽  
Fatma Huffman ◽  
Juan Liuzzi ◽  
Tan Li ◽  
Vijaya Narayanan
Keyword(s):  
Blood Pressure ◽  
Vitamin D ◽  
Cardiovascular Diseases ◽  
Advanced Glycation End Products ◽  
Serum Levels ◽  
Vitamin D Insufficiency ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products ◽  
The Relationship

Abstract Objectives Advanced Glycation End Products, (AGEs) and their soluble receptor (sRAGE) have been implicated in the development of complications and mortality among individuals with type 2 diabetes (T2D). There is limited information on the relationship between AGEs and sRAGE and risk of cardiovascular diseases (CVD) in minority groups, who have a higher burden of T2D. The relationship between AGEs and sRAGE and CVD risks in adults with T2D and vitamin D insufficiency/deficiency was assessed in a minority population. Methods A cross sectional study of Hispanics and African Americans with T2D (n = 64, 41 women and 23 men, mean age = 54 ± 9) recruited from two clinics in Miami Dade. Systolic (SBP) and diastolic blood pressure (DBP), weight and height measurement and serum lipid profile were completed. ELISA kits were used to assess serum levels of AGEs (Biotang Inc/TSZ Elisa, Waltham, MA, USA) and sRAGE (Biotang Inc/TSZ Elisa, Waltham, MA, USA). Multiple linear regression was used to assess association between AGEs, sRAGE and CVD risks. Results A negative and significant association between AGEs and high-density lipoprotein cholesterol (HDL-C)(B = −0.551, P = 0.029) was found. The relationship between AGEs and HDL-C persisted after adjusting for covariates (P < 0.05). sRAGE was significantly associated with SBP (B = 0.015, P = 0.025) and diastolic blood pressure DBP (B = 0.0271, P = 0.037). Results loss significance when association between sRAGE and DBP and SBP were adjusted for covariates such as age, body mass index (BMI), smoking and alcohol intake. Conclusions Our results suggest that AGEs and sRAGE are related to markers of cardiovascular risk such as HDL-C, SBP and DBP in the study population of African Americans and Hispanics with T2D and vitamin D insufficiency/deficiency. Measures on reducing serum levels of AGEs and improving sRAGE and vitamin D are warranted in these populations for risk reduction of CVD. Funding Sources Partial funding for this research was provided through an NIH/NIDDK sponsored grant.

Thyroid functioning, adipocytokines, bone turnover and vitamin D - review of literature

2016 ◽  
Vol 6 (1) ◽  
pp. 0-0
Author(s):  
A. Koszowska ◽  
A. Brończyk-Puzoń ◽  
A. Dittfeld ◽  
J. Nowak ◽  
K. Kulik-Kupka ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cardiovascular Diseases ◽  
Bone Turnover ◽  
Whole Body ◽  
Fatty Tissue ◽  
Review Of Literature ◽  
Efficient Treatment ◽  
Thyroid Gland Function ◽  
Gland Function ◽  
Metabolic Dysfunctions

The most common public health problems include, among others, overweight, obesity, and cardiovascular diseases. In addition, the number of people with thyroid disturbances is still growing. Thyroid abnormalities can lead to many metabolic dysfunctions, including secondary osteoporosis, alterations in body mass, lipid profile, and insulin resistance. Recently, the studies have been focused on the connections between thyroid gland function, obesity, metabolic syndrome and cardiovascular diseases, as well as bone turnover. Fatty tissue plays an important role in whole body homeostasis. Adipose tissue hormones, such as leptin, resistin and adiponectin are proteins having immunomodulatory lproperties, and their balance is needed to control immune response, as well as inflammation processes. The following article constitutes a review of literature concerning thyroid function with regard to adipocytokines and vitamin D, as well as the influence of this gland on the skeletal system. For this purpose, Medline Pub Med base and Google Scholar were used. All the citied studies in this review article underline how much should be done to achieve more efficient treatment of thyroid disorders, specifically, how to prevent its complications, for instance, osteoporosis, over-weight, obesity or cardiovascular diseases.

Vitamin D Deficiency and Cardiovascular Diseases

2020 ◽  
Vol 12 (1) ◽  
pp. 27-37
Author(s):  
Yifei Wang ◽  
Shi Zhou ◽  
Shuai Lei ◽  
Liying Hao ◽  
Deri Sun ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cardiovascular Diseases ◽  
Vitamin D Deficiency ◽  
Cardiovascular Events ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Hormone Effects ◽  
Peptide Expression ◽  
Novel Strategy ◽  
Underlying Mechanisms

In recent years, there are increasing evidences of epidemiology and clinic which indicate that vitamin D deficiency has relationship with cardiovascular disease. It was found the levels of vitamin D were negatively correlated with cardiovascular events such as hypertension, heart failure, atrial fibrillation and coronary heart disease. This article reviews the connection between cardiovascular diseases and vitamin D, and explains the underlying mechanisms including regulating renin-angiotensin system or endothelial function, inhibition of natriuretic peptide expression or the release of parathyroid hormone, effects on inflammation or obesity, bioenergetics, activation of extracellular Ca2+, inhibition of oxidative stress, and so on. These mechanisms provide novel strategy for the treatment of these cardiovascular diseases.

Can oral vitamin D prevent the cardiovascular diseases among migrants in Australia? Provider perspective using Markov modelling

2015 ◽  
Vol 42 (6) ◽  
pp. 596-601 ◽  
Author(s):  
Thilanga Ruwanpathirana ◽  
Alice Owen ◽  
Andre MN Renzaho ◽  
Ella Zomer ◽  
Manoj Gambhir ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cardiovascular Diseases ◽  
Oral Vitamin ◽  
Markov Modelling ◽  
Provider Perspective

scholarly journals Effect of Hypovitaminosis D on Lipid Profile in Hypothyroid Patients in Saudi Arabia

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Awad S. Alsamghan ◽  
Safar A. Alsaleem ◽  
Mohammed A. S. Alzahrani ◽  
Ayyub Patel ◽  
Ayaz K. Mallick ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Cardiovascular Diseases ◽  
Total Cholesterol ◽  
Cell Function ◽  
Early Stage ◽  
Thyroid Stimulating Hormone ◽  
Vitamin D Levels ◽  
Hypothyroid Patients ◽  
Tsh Levels

Background. Hypothyroidism is believed to be associated with dyslipidemia and is considered a risk factor for the development of atherosclerotic cardiovascular diseases (ASCVD). Vitamin D, due to its steroid hormone action, retains cell function and controls the metabolism of lipids. Therefore, the present study was carried out to show the association of the risk factors of ASCVD and deficiency of thyroid hormones and vitamin D levels since no previous studies have been performed on Saudi patients before. Methodology. A retrospective cohort study was carried out on 400 hypothyroid patients. Medical records of those patients were followed up and were classified as normal and hypothyroid patients according to their thyroid-stimulating hormone levels. TSH, vitamin D, and lipid profiles were determined using the ELISA technique. Result. Total cholesterol, triglyceride, and low-density lipoprotein cholesterol levels were significantly higher in hypothyroid patients than those in the normal group. We have found a significant correlation between TSH levels and the risk factors of ASCVD (total cholesterol, triglycerides, and LDL-C). Moreover, a significant correlation between vitamin D levels and the risk factors of ASCVD (total cholesterol, triglycerides, and LDL-C) has been found. In addition, there is a correlation between deficiency of Vit D and low-TSH levels (95% CI 1.092–4.05) indicating a higher risk for the development of ASCVD among those patients. Conclusion. Hypothyroid and vitamin D-deficient patients must be screened regularly at an early stage to predict and also to prevent cardiovascular diseases. Moreover, an adequate supply of vitamin D and TH should be given to those patients to prevent cardiovascular diseases at an early stage.

scholarly journals PARTICIPATION OF VITAMIN D IN PATHOGENESIS OF CARDIOVASCULAR DISEASES

2018 ◽  
Vol 63 (5) ◽  
pp. 43-50 ◽  
Author(s):  
A. N. Kolesnikov ◽  
A. V. Dubovaya ◽  
Yu. V. Udovitchenko
Keyword(s):  
Vitamin D ◽  
Cardiovascular Diseases ◽  
Cardiac Death ◽  
Cardiac Rhythm ◽  
Low Density Lipoproteins ◽  
Controlled Trials ◽  
Low Density ◽  
Randomized Controlled ◽  
Highly Correlated ◽  
Overall Mortality

The article presents data of experimental and clinical studies devoted to the influence of vitamin D on the origin and progression of the cardiovascular diseases: arterial hypertension, atherosclerosis, coronary heart disease, cardiac rhythm disturbances. The results of the studies indicate that a pronounced deficiency of vitamin D is highly correlated with sudden cardiac death, cardiovascular catastrophes, and overall mortality. The decrease in vitamin D is followed by an increase in total cholesterol, low-density lipoproteins and triglycerides, an increase in the heart rate and the level of systolic blood pressure. The Meta-analyzes of randomized controlled trials demonstrated that the addition of vitamin D to treatment and rehabilitation measures of the patients with cardiovascular disease helps to reduce overall mortality.

scholarly journals Vitamin D and atherosclerosis

2021 ◽  
Vol 12 (1) ◽  
pp. 99-108
Author(s):  
Vesna Lazić ◽  
Biljana Mijović ◽  
Miloš Maksimović ◽  
Olivera Rašević ◽  
Maida Mulić ◽  
...  
Keyword(s):  
Physical Activity ◽  
Vitamin D ◽  
Cardiovascular Diseases ◽  
Endothelial Dysfunction ◽  
World Health ◽  
Risk Marker ◽  
Increased Risk ◽  
The World ◽  
Calcium And Phosphorus ◽  
Health Organization

Cardiovascular diseases rank first on the mortality list globally or 31%. The basic measure of prevention in accordance with the recommendations of the World Health Organization is a change in risk lifestyle in terms of diet, physical activity, tobacco and alcohol consumption. Vitamin D was previously recognized as a regulator of calcium and phosphorus ratio, bone remodeling or the main controller of skeletal pathophysiology. However, vitamin D enjoys great interest in clinical and epidemiological research in terms of its possible impact on reducing the risk of cardiovascular diseases. Among other things, vitamin D deficiency is associated with an increased risk of endothelial dysfunction. Although the deficiency has been identified as a risk marker for cardiovascular diseases, the mechanism of action of vitamin D on the path from endothelial dysfunction to cardiovascular diseases has not been fully revealed. The findings in this segment of activity of vitamin D would be significant in terms of reducing morbidity and mortality from cardiovascular diseases.

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