Calcium supplements with vitamin D do not increase risk of cardiovascular diseases: Results from a randomized controlled trial

Bone ◽  
2011 ◽  
Vol 48 ◽  
pp. S76
Author(s):  
L. Rejnmark⁎ ◽  
P. Vestergaard ◽  
L. Mosekilde
Keyword(s):  
Vitamin D ◽  
Randomized Controlled Trial ◽  
Cardiovascular Diseases ◽  
Controlled Trial ◽  
Calcium Supplements ◽  
Randomized Controlled ◽  
Increase Risk

scholarly journals Effect of 12-weeks elastic band resistance training on MyomiRs and osteoporosis markers in elderly women with Osteosarcopenic obesity: a randomized controlled trial

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ebrahim Banitalebi ◽  
Majid Mardaniyan Ghahfarrokhi ◽  
Mortaza Dehghan
Keyword(s):  
Vitamin D ◽  
Randomized Controlled Trial ◽  
Type I Collagen ◽  
Assessment Tool ◽  
Elderly Women ◽  
Controlled Trial ◽  
Type I ◽  
Elastic Band ◽  
Randomized Controlled ◽  
Osteosarcopenic Obesity

Abstract Background Interorgan communication networks established during exercise in several different tissues can be mediated by several exercise-induced factors. Therefore, the present study aimed to investigate the effects of resistance-type training using elastic band-induced changes of myomiRs (i.e., miR-206 and miR-133), vitamin D, CTX-I, ALP, and FRAX® score in elderly women with osteosarcopenic obesity (OSO). Methods In this randomized controlled trial, 63 women (aged 65–80 years) with Osteosarcopenic Obesity were recruited and assessed, using a dual-energy X-ray absorptiometry instrument. The resistance-type training via elastic bands was further designed three times per week for 12-weeks. The main outcomes were Fracture Risk Assessment Tool score, bone mineral content, bone mineral density, vitamin D, alkaline phosphatase, C-terminal telopeptides of type I collagen, expression of miR-206 and miR-133. Results There was no significant difference between the study groups in terms of the Fracture Risk Assessment Tool score (p = 0.067), vitamin D (p = 0.566), alkaline phosphatase (p = 0.334), C-terminal telopeptides of type I collagen (p = 0.067), microR-133 (p = 0.093) and miR-206 (p = 0.723). Conclusion Overall, the results of this study illustrated 12-weeks of elastic band resistance training causes a slight and insignificant improvement in osteoporosis markers in women affected with Osteosarcopenic Obesity. Trial registration Randomized controlled trial (RCT) (Iranian Registry of Clinical Trials, trial registration number: IRCT20180627040260N1. Date of registration: 27/11/2018.

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