scholarly journals Leukemia cutis preceding bone marrow relapse in acute monocytic leukemia

2016 ◽  
Vol 82 (6) ◽  
pp. 713 ◽  
Author(s):  
Najmaddin Khoshnaw ◽  
BelalA Muhammad
Keyword(s):  
Bone Marrow ◽  
Acute Monocytic Leukemia ◽  
Monocytic Leukemia ◽  
Leukemia Cutis

Translocation (X;20)(q13;q13.3): Report of Three Additional Cases.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 4264-4264
Author(s):  
Chandrika Sreekantaiah
Keyword(s):  
Bone Marrow ◽  
Myeloid Leukemia ◽  
Bone Marrow Aspiration ◽  
Unknown Etiology ◽  
Acute Monocytic Leukemia ◽  
Monocytic Leukemia ◽  
Presenting Symptoms ◽  
Recurrent Translocation ◽  
History Of

We report a recurrent translocation (X;20)(q13;q13.3) in three patients. The translocation was the sole chromosomal abnormality in all three patients and the number of cells with the abnormality varied from three to seventeen out of twenty metaphases analyzed for each patient. The patients were all female with ages ranging from 66 to 83. The presenting symptoms were variable but all included a history of anemia. Bone marrow aspiration showed acute monocytic leukemia in one patient and normocellular bone marrow with no detectable morphologic or immunophenotypic evidence of neoplasm in the other two. Only eight cases with the translocation have previously been reported. Seven of these cases had either myelodysplastic syndrome or acute myeloid leukemia and one patient had pancytopenia of unknown etiology. Repeated bone marrow evaluations on this patient showed no dyspoietic changes. The t(X;20) has clearly been established as a nonrandom abnormality, however, the clinical significance of the translocation is not clear. Close follow up of these patients is therefore essential. Characterization at the molecular level will also help to determine the genes involved and the mechanism of their action.

scholarly journals Aleukemic Leukemia Cutis Manifesting with Disseminated Nodular Eruptions and a Plaque Preceding Acute Monocytic Leukemia: A Case Report

2011 ◽  
Vol 4 (3) ◽  
pp. 547-554 ◽  
Author(s):  
Ipek Yonal ◽  
Fehmi Hindilerden ◽  
Raif Coskun ◽  
Oner Ibrahim Dogan ◽  
Meliha Nalcaci
Keyword(s):  
Case Report ◽  
Acute Monocytic Leukemia ◽  
Monocytic Leukemia ◽  
Aleukemic Leukemia Cutis ◽  
Leukemia Cutis

scholarly journals Leukemia Cutis – A Case Report

2018 ◽  
Vol 10 (4) ◽  
pp. 119-123
Author(s):  
Dušan Mihajlović ◽  
Miroslav Dinić ◽  
Željko Mijušković ◽  
Nenad Petrov ◽  
Olga Radić Tasić ◽  
...  
Keyword(s):  
Blood Cells ◽  
Punch Biopsy ◽  
Acute Monocytic Leukemia ◽  
Peripheral Blood Cells ◽  
Monocytic Leukemia ◽  
Diffuse Infiltration ◽  
Skin Punch Biopsy ◽  
Leukemia Cutis ◽  
Immunophenotypic Analysis ◽  
Made In

Abstract Leukemia cutis is a specific skin lesion which is characterized by diffuse infiltration of neoplastic cells and can occur in all types of leukemia. Leukemia cutis can have varied cutaneous presentations such as papules, macules, nodules, plaques and ulcers. We report a case of 52-year-old woman who presented with erythematous macules and papules over her trunk, thighs and upper arms. A skin punch biopsy showed monomorphic, perivascular and periadnexal infiltration by the cells positive for CD45, CD15, CD68 and lysozyme. According to the subsequent bone marrow biopsy and immunophenotypic analysis of peripheral blood cells, the diagnosis of acute monocytic leukemia (FAB AML-M5b) was made. In our case, the first clinical sign suggestive of the diagnosis of leukemia was the presence of erythematous macules and papules. Therefore, we believe that leukemia cutis should be taken into consideration in the differential diagnosis of maculopapular rush on the trunk, upper arms and leg

Pernicious Anemia Mimicking MDS by Del(3p) in Cytogenetics and Monocytic Leukemia in Trephine Biopsy by Highly Expression of CD163 Positive Cells

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 5038-5038
Author(s):  
Stefani Parmentier ◽  
Jörg Meinel ◽  
Christiane Jakob ◽  
Anke Frömmel ◽  
Brigitte Mohr ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Vitamin B12 ◽  
Pernicious Anemia ◽  
Vitamin B12 Deficiency ◽  
Acute Monocytic Leukemia ◽  
Monocytic Leukemia ◽  
Normal Range ◽  
Cytogenetic Aberration ◽  
B12 Deficiency ◽  
Blast Cells

Abstract Abstract 5038 Case Report We report of a 53 year old woman who presented repeatedly with syncopes over a period of 3 months. Laboratory results revealed severe pancytopenia (Hb 4.6 mmol/l (7.4 g/dl), WBC 1.22 Gpt/L, platelet count 13 Gpt/L) and severe hemolysis (haptoglobin < 0.20 g/l, normal range 0.3–2.0 g/l; LDH 33.1 μmol/s*l, normal range 2.25–3.55 μmol/s*l). Routine examination of the bone marrow aspirate showed typical features of megaloblastic erythropoiesis, which could be confirmed by a low serum cobalamin level (53 pg/ml, normal 211–911 pg/ml) and the presence of anti-intrinsic factor antibody (16.84 U/ml). Additionally, atrophic gastritis was seen in biopsies taken of gastric mucosa. The diagnosis of pernicious anemia was suspected and the patient treated with cobalamin. Except for hemoglobin, the peripheral blood counts recovered within one week. Meanwhile, cytogenetics from the bone marrow revealed metaphases with del(3p) and histopathological results were suspicious of an increased number of blast cells with highly expression of CD163 possibly mimicking MDS or (acute) monocytic leukemia. Therefore, bone marrow examination was repeated two weeks after recovery, which still showed dysplastic changes paralleling hematopoietic recovery but no increased number of blast cells. Additionally, the cytogenetic aberration had disappeared. Discussion Diagnostic work-up for megaloblastic anemia rarely includes cytogenetic analysis of bone marrow cells. Therefore, the finding of a transient cytogenetic aberration has possibly not reported frequently before in the literature. In our case, the initial finding of del(3p) appears to be due to ineffective hematopoiesis caused by vitamin B12 deficiency which leads to impaired DNA synthesis and genomic instability. This might be an explanation for this cytogenetic abnormality which disappeared after substitution of cobalamin. CD163 is exclusively expressed on monocytes and macrophages and with signs of (slightly) increased blast counts might mimic (acute) monocytic leukemia. However, in pernicious anemia with severe hemolysis as seen in this case it might reflect an acute phase reaction, as CD163 represents a signal-inducing macrophage receptor that scavenges haemoglobin by mediating endocytosis of haptoglobin-hemoglobin complexes. In conclusion, vitamin B12 deficiency might be associated with cytogenetic abnormalities and thus in addition to the bone marrow morphology feign certain haematological diseases. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Cytochemical, functional, and proliferative characteristics of promonocytes and monocytes from patients with monocytic leukemia

Blood ◽  
1983 ◽  
Vol 62 (2) ◽  
pp. 298-304 ◽  
Author(s):  
R van Furth ◽  
TL van Zwet
Keyword(s):  
Bone Marrow ◽  
Peripheral Blood ◽  
Predictive Value ◽  
Mononuclear Phagocytes ◽  
Acute Monocytic Leukemia ◽  
Blood Monocytes ◽  
Monocytic Leukemia ◽  
Peripheral Blood Monocytes ◽  
Normal Individuals ◽  
The Mean

Abstract This article deals with a prospective study on the cytochemical, functional, and proliferative characteristics of promonocytes and bone marrow and peripheral blood monocytes of 20 patients with acute monocytic leukemia and 7 patients with chronic monocytic leukemia. The results show a wide variation in the peroxidase and esterase activities in these cells, whereas the percentages of mononuclear phagocytes with Fc gamma and C3b receptors did not differ appreciably from those in normal individuals. A discriminant analysis of these data and corresponding data from normal individuals showed that a below-normal peroxidase activity of circulating monocytes has predictive value for the presence of monocytic leukemia; a below-normal esterase activity has less, but nevertheless some, predictive value in this respect. An increase in the percentage of circulating monocytes, a decrease in the percentage of Fc gamma or C3b receptors, and a decline in the ability to phagocytose bacteria has no predictive value for the presence of monocytic leukemia. The mean percentage of patients' promonocytes that incorporated 3H-thymidine amounted to 80.9%, which is close to the control value in normal individuals. The mean values for the labeling indices of cultured bone marrow and peripheral blood monocytes are 1.0% and 0.74%, respectively; when 3H-thymidine was added to whole blood, the labeling index of the monocytes amounted to 3.6%. These percentages are only a little higher than those found for monocytes of normal individuals. These results indicate that the majority of the circulating monocytes in acute and chronic monocytic leukemia are not actively dividing or blast cells.

An unusual initial manifestation of acute myeloid leukemia

2016 ◽  
Vol 28 (4) ◽  
pp. 418-420
Author(s):  
Sonali R Gawai ◽  
VG Binesh ◽  
Ambooken Betsy ◽  
KT Jisha
Keyword(s):  
Myeloid Leukemia ◽  
Bone Marrow Aspirate ◽  
Acute Monocytic Leukemia ◽  
Low Grade ◽  
Monocytic Leukemia ◽  
Peripheral Smear ◽  
Initial Manifestation ◽  
Leukemia Cutis ◽  
Genital Ulcers ◽  
Generalized Lymphadenopathy

Leukemia cutis is seen in around 20% of acute monocytic leukemia. They usually present as papules or nodules or infiltrated plaques but ulceration is uncommon. A 28-year-old female presented with multiple painless indurated genital ulcers of three weeks’ duration with low-grade fever, gum hyperplasia, and generalized lymphadenopathy. Tissue smear from the edge of the ulcer showed atypical monocytes suggestive of leukemic infiltrate which was further confirmed by peripheral smear and bone marrow aspirate. Herein, we report a case of acute monocytic leukemia (AML) with leukemia cutis presenting initially with genital ulcers simulating chancre.

scholarly journals Leukemia cutis in a patient with acute monocytic leukemia diagnosed simultaneously with hepatocellular carcinoma: A case study

2013 ◽  
Vol 6 (5) ◽  
pp. 1319-1322
Author(s):  
DONG KEUN SEOK ◽  
SAE YOON KEE ◽  
SOON YOUNG KO ◽  
JUNG HWA LEE ◽  
HYE YOUNG KIM ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Acute Monocytic Leukemia ◽  
Monocytic Leukemia ◽  
Leukemia Cutis

scholarly journals HEMOPHAGOCYTOSIS BY BLASTS IN A CHILD WITH ACUTE MONOCYTIC LEUKEMIA AFTER CHEMOTHERAPY

2021 ◽  
Vol 39 ◽  
Author(s):  
Mariela Granero Farias ◽  
Priscila Aparecida Correa Freitas ◽  
Fabiane Spagnol ◽  
Meriene Viquetti de Souza ◽  
Ana Paula Alegretti ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Chemotherapy Regimen ◽  
Normal Karyotype ◽  
University Hospital ◽  
Leukemic Cells ◽  
Abnormal Behavior ◽  
Acute Monocytic Leukemia ◽  
Monocytic Leukemia ◽  
Diagnostic Profile ◽  
Rare Malignancy

ABSTRACT Objective: To describe the case of a child who presented hemophagocytic lymphohistiocytosis (HLH) associated with acute monocytic leukemia after chemotherapy, with hemophagocytosis caused by leukemic cells. Case description: In a university hospital in Southern Brazil, a 3-year-old female was diagnosed with acute monocytic leukemia with normal karyotype. The chemotherapy regimen was initiated, and she achieved complete remission six months later, relapsing after four months with a complex karyotype involving chromosomes 8p and 16q. The bone marrow showed vacuolated blasts with a monocytic aspect and evidence of hemophagocytosis. The child presented progressive clinical deterioration and died two months after the relapse. Comments: HLH is a rare and aggressive inflammatory condition characterized by cytopenias, hepatosplenomegaly, fever, and hemophagocytosis in the bone marrow, lymph nodes, spleen, and liver. Although rare, malignancy-associated HLH (M-HLH) is fatal. The patient in this case report met five out of the eight established criteria for HLH. The evolution of the patient’s karyotype, regardless of the diagnostic profile, seemed secondary to the treatment for acute monocytic leukemia. In this case, the cytogenetic instability might have influenced the abnormal behavior of leukemic cells. This is a rare case of HLH in a child with acute monocytic leukemia.

scholarly journals Salvage chemotherapy for the treatment of Leukemia cutis in a patient with acute monocytic leukemia

2019 ◽  
Vol 6 (1) ◽  
pp. 2970-2973
Author(s):  
Mehrdad Payandeh ◽  
Afshin Karami ◽  
Noorodin Karami ◽  
Soode Enayati ◽  
Mehrnoush Aeinfar
Keyword(s):  
Salvage Chemotherapy ◽  
Acute Monocytic Leukemia ◽  
Monocytic Leukemia ◽  
Leukemia Cutis
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