Effects of Calpain-10 and Adiponectin Gene Polymorphisms on Insulin Secretion and Resistance in Patients with Type 2 Diabetes Mellitus

2010 ◽  
Vol 11 (3) ◽  
pp. 229
Author(s):  
Jeong Woo Han ◽  
Woo Ho Shim ◽  
Eun Hae Lee ◽  
Young Mi Lee ◽  
Min Goo Kim ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Insulin Secretion ◽  
Gene Polymorphisms ◽  
Adiponectin Gene ◽  
Calpain 10

scholarly journals Calpain-10 gene polymorphisms and risk of type 2 diabetes mellitus in Mexican mestizos

2015 ◽  
Vol 14 (1) ◽  
pp. 2205-2215 ◽  
Author(s):  
V.J. Picos-Cárdenas ◽  
E. Sáinz-González ◽  
A. Miliar-García ◽  
A. Romero-Zazueta ◽  
R. Quintero-Osuna ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Gene Polymorphisms ◽  
Calpain 10 ◽  
Mexican Mestizos

Adiponectin gene polymorphisms as a predictor for development of type 2 diabetes mellitus in Iraqi population

Gene ◽  
2018 ◽  
Vol 662 ◽  
pp. 118-122 ◽  
Author(s):  
Majid Kadhum Hussain ◽  
Falah Abdulhasan Deli ◽  
Abdul Hussein A. Algenabi ◽  
Khalid H. Abdul-Rudha
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Gene Polymorphisms ◽  
Adiponectin Gene

Association of calpain 10 gene polymorphisms with type 2 diabetes mellitus in Southern Indians

Metabolism ◽  
2010 ◽  
Author(s):  
Dhanasekaran Bodhini ◽  
Venkatesan Radha ◽  
Saurabh Ghosh ◽  
Krishna R. Sanapala ◽  
Partha P. Majumder ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Gene Polymorphisms ◽  
Calpain 10

scholarly journals Association between Adiponectin Gene Polymorphism and Environmental Risk Factors of Type 2 Diabetes Mellitus among the Chinese Population in Hohhot

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Meng Cui ◽  
Yumin Gao ◽  
Yanping Zhao ◽  
Hui Pang ◽  
Le Chen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Environmental Risk ◽  
Gene Polymorphisms ◽  
Central Obesity ◽  
Environmental Risk Factors ◽  
Adiponectin Gene

Objective. The aim of this study was to investigate the association between adiponectin gene polymorphisms rs10937273, rs1501299, rs182052, rs2241767, and rs266729 and environmental risk factors of type 2 diabetes mellitus (T2DM) in Hohhot. The study explored different models of gene-environment interactions, aimed at providing approaches for the prevention and control of T2DM in combination with the characteristics of the local population. Methods. A case-control study was conducted including 406 Chinese participants, comprising 203 cases and 203 controls from various hospitals. Adiponectin (ADIPOQ) gene polymorphisms rs10937273, rs1501299, rs182052, rs2241767, and rs266729 were detected using an improved multiple ligation detection reaction technique. Generalized multifactor dimensionality reduction (GMDR) and logistic regression were conducted to analyze the associations between adiponectin gene polymorphisms and T2DM, as well as the interactions between adiponectin gene polymorphisms and environmental factors. Results. ADIPOQ gene polymorphisms rs10937273, rs1501299, rs182052, rs2241767, and rs266729 were associated with type 2 diabetes. Based on the haplotype of the five adiponectin gene single-nucleotide polymorphism (SNP) loci, we found that G-G-A-A-C was a susceptible haplotype of T2DM (P<0.05). Interaction analyses demonstrated associations between rs1501299 and central obesity (consistency=80%, P=0.011) and between rs266729 and rs182052 and central obesity (consistency=70%, P=0.011). Conclusions. Our findings indicate that there is an interaction between the ADIPOQ gene and central obesity, which provides new insights into the prevention and treatment of T2DM.

Mitochondrial D-Loop gene polymorphisms in the patients with type 2 diabetes mellitus

2009 ◽  
Vol 31 (3) ◽  
pp. 265-272 ◽  
Author(s):  
Fang-Jian CHEN ◽  
Hong YU ◽  
Fan FAN ◽  
Jian-Xin LU
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Gene Polymorphisms ◽  
D Loop

Echinops Spp. Polysaccharide B Ameliorates Metabolic Abnormalities in a Rat Model of Type 2 Diabetes Mellitus

2020 ◽  
Vol 19 (1) ◽  
pp. 106-114
Author(s):  
Guang Hao ◽  
Xiaoyu Ma ◽  
Mengru Jiang ◽  
Zhenzhen Gao ◽  
Ying Yang
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Insulin Secretion ◽  
Insulin Receptor ◽  
Skeletal Muscles ◽  
Insulin Receptor Substrate ◽  
Sprague Dawley

This study examined the in vivo effects of Echinops spp. polysaccharide B on type 2 diabetes mellitus in Sprague-Dawley rats. We constructed a type 2 diabetes mellitus Sprague-Dawley rat models by feeding a high-fat and high-sugar diet plus intraperitoneal injection of a small dose of streptozotocin. Using this diabetic rat model, different doses of Echinops polysaccharide B were administered orally for seven weeks. Groups receiving Xiaoke pill and metformin served as positive controls. The results showed that Echinops polysaccharide B treatment normalized the weight and blood sugar levels in the type 2 diabetes mellitus rats, increased muscle and liver glycogen content, improved glucose tolerance, increased insulin secretion, and reduced glucagon and insulin resistance indices. More importantly, Echinops polysaccharide B treatment upregulated the expression of insulin receptor in the liver, skeletal muscles, and pancreas, and significantly improved the expression levels of insulin receptor substrate-2 protein in the liver and pancreas, as well as it increased insulin receptor substrate-1 expression in skeletal muscles. These two proteins play crucial roles in increasing insulin secretion and in controlling type 2 diabetes mellitus. The findings of the present study suggest that Echinops polysaccharide B could improve the status of diabetes in type 2 diabetes mellitus rats, which may be achieved by improving insulin resistance. Our study provides a new insight into the development of a natural drug for the control of type 2 diabetes mellitus.

Kcne2 deletion impairs insulin secretion and causes type 2 diabetes mellitus

2017 ◽  
Vol 31 (6) ◽  
pp. 2674-2685 ◽  
Author(s):  
Soo Min Lee ◽  
Jasmine Baik ◽  
Dara Nguyen ◽  
Victoria Nguyen ◽  
Shiwei Liu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Insulin Secretion
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