scholarly journals Association between Adiponectin Gene Polymorphism and Environmental Risk Factors of Type 2 Diabetes Mellitus among the Chinese Population in Hohhot

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Meng Cui ◽  
Yumin Gao ◽  
Yanping Zhao ◽  
Hui Pang ◽  
Le Chen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Environmental Risk ◽  
Gene Polymorphisms ◽  
Central Obesity ◽  
Environmental Risk Factors ◽  
Adiponectin Gene

Objective. The aim of this study was to investigate the association between adiponectin gene polymorphisms rs10937273, rs1501299, rs182052, rs2241767, and rs266729 and environmental risk factors of type 2 diabetes mellitus (T2DM) in Hohhot. The study explored different models of gene-environment interactions, aimed at providing approaches for the prevention and control of T2DM in combination with the characteristics of the local population. Methods. A case-control study was conducted including 406 Chinese participants, comprising 203 cases and 203 controls from various hospitals. Adiponectin (ADIPOQ) gene polymorphisms rs10937273, rs1501299, rs182052, rs2241767, and rs266729 were detected using an improved multiple ligation detection reaction technique. Generalized multifactor dimensionality reduction (GMDR) and logistic regression were conducted to analyze the associations between adiponectin gene polymorphisms and T2DM, as well as the interactions between adiponectin gene polymorphisms and environmental factors. Results. ADIPOQ gene polymorphisms rs10937273, rs1501299, rs182052, rs2241767, and rs266729 were associated with type 2 diabetes. Based on the haplotype of the five adiponectin gene single-nucleotide polymorphism (SNP) loci, we found that G-G-A-A-C was a susceptible haplotype of T2DM (P<0.05). Interaction analyses demonstrated associations between rs1501299 and central obesity (consistency=80%, P=0.011) and between rs266729 and rs182052 and central obesity (consistency=70%, P=0.011). Conclusions. Our findings indicate that there is an interaction between the ADIPOQ gene and central obesity, which provides new insights into the prevention and treatment of T2DM.

Adiponectin gene polymorphisms as a predictor for development of type 2 diabetes mellitus in Iraqi population

Gene ◽  
2018 ◽  
Vol 662 ◽  
pp. 118-122 ◽  
Author(s):  
Majid Kadhum Hussain ◽  
Falah Abdulhasan Deli ◽  
Abdul Hussein A. Algenabi ◽  
Khalid H. Abdul-Rudha
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Gene Polymorphisms ◽  
Adiponectin Gene

scholarly journals Endothelin-1 Gene Polymorphisms rs5370, rs1476046, and rs3087459 are not Associated with Diabetic Nephropathy in Caucasians with Type 2 Diabetes Mellitus

Folia Medica ◽  
2017 ◽  
Vol 59 (3) ◽  
pp. 261-269 ◽  
Author(s):  
Maja Šeruga ◽  
Stojan Kariž ◽  
Jana Makuc ◽  
Matej Završnik ◽  
Ines Cilenšek ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Gene Polymorphisms ◽  
Significant Difference ◽  
Study Population ◽  
Lines Of Evidence

AbstractBackground:Diabetic nephropathy (DN) is a major microvascular complication of type 2 diabetes mellitus (T2DM). Several lines of evidence implicate the endothelin (ET) system in the pathophysiology of DN. The aim of the present study was to analyze if genetic polymorphisms of the ET-1 (EDN1) gene affect susceptibility to DN in Caucasians with T2DM.Materials and methods:The study population consisted of 651 Caucasian subjects with T2DM of more than 10 years’ duration: 276 patients with DN (cases) and 375 patients without evidence of DN (controls). Polymorphisms in ET-1 (EDN1) gene, rs5370, rs1476046, and rs3087459, were studied.Results:Genotype distributions of the studied polymorphisms showed no significant difference between cases and controls.Conclusions:We provide evidence that the rs5370, rs1476046, and rs3087459 polymorphisms ofEDN1gene are not risk factors for DN in Caucasians with T2DM.

scholarly journals The Association of Antioxidants Gene Polymorphisms (SOD2 Ala16Val, GPx1 Pro198Leu, GSTP1 Ile105Val, and Cat −21 A/T) and Risk of Type 2 Diabetes Mellitus

2020 ◽  
Vol 8 (A) ◽  
pp. 781-786
Author(s):  
Mutiara Indah Sari ◽  
Siti Syarifah ◽  
Milahayati Daulay ◽  
Zaimah Z. Tala
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Gene Polymorphisms ◽  
Recessive Model ◽  
Increased Risk ◽  
Gstp1 Ile105val ◽  
Cat Gene

BACKGROUND: Antioxidant gene polymorphism is one of the genetic risk factors associated with type 2 diabetes mellitus (T2DM) incidence. AIM: This study was to analyze the association of superoxide dismutase 2 (SOD2) Ala16VAl, glutathione peroxidase (GPx1) Pro198Leu, glutathione S-transferase Pi1 (GSTP1) Ile105Val, and Cat −21 A/T gene polymorphisms and risk of T2DM. METHODS: We genotyped deoxyribonucleic acid of 120 T2DM patients and 80 healthy control by polymerase chain reaction and restriction fragment length polymorphism method, using a specific restriction enzyme. RESULTS: This study showed that the Val/Val of SOD2 was significantly associated with an increased risk of T2DM compared to the Ala/Ala+Ala/Val (p = 0.011; odds ratio [OR] = 2.220; confidence interval [CI] = 1.234–3.992). The TT genotype of Cat gene was also significantly associated with an increased risk of T2DM compared to the AA genotype (p = 0.027; OR = 5.000; CI = 1.079–23.176) and TT genotype to the AA+AT genotype (p = 0,030; OR = 4.738; CI = 1.039–21.600). However, there was no difference in all genetic models of GPx1 Pro198Leu and GSTP1 Ile105Val gene polymorphisms (p > 0.05). CONCLUSION: This study indicates that the Val/Val under the recessive model of SOD2 gene also TT genotype under the co-dominant model of Cat gene and TT genotype under the recessive model of Cat gene were associated with risk factors for T2DM occurrence.

scholarly journals Central obesity increases the risk of type 2 diabetes mellitus among urban adults

2016 ◽  
Vol 34 (3) ◽  
pp. 187
Author(s):  
Julianty Pradono ◽  
Nunik Kusumawardani ◽  
Delima Delima
Keyword(s):  
Physical Activity ◽  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Central Obesity ◽  
Economic Status ◽  
Multiple Logistic Regression Analysis ◽  
Urban Adults

Background<br />In Indonesia the number of persons with type 2 diabetes mellitus (T2DM) was 8.5 million in 2013, and is estimated to be 11.8 million in 2030. The aim of this study was to determine the major risk factors associated with T2DM prevalence in urban aged &gt;15 years.<br /><br />Methods<br />An observational study with cross-sectional design was used with the data from Riskesdas 2007 and 2013 on population aged &gt;15 years. Total respondents were 294,352 (2007) and 368,281 (2013). Data were collected by trained personnel through interviews, blood pressure and anthropometry measurements, and blood glucose and lipid tests. Odds ratio (OR) was used to test the relationship between T2DM and a number of other variables. Multiple logistic regression analysis was obtained to determine the main risk factor associated with T2DM prevalence.<br /><br />Results<br />Type 2 diabetes mellitus prevalence increased from 2.3% (2007) to 2.5% (2013). T2DM tended to be increased in the younger age groups. Low education, middle-to-high economic status, less physical activity, smoking &gt;200 cigarettes, and high risk blood lipid levels were strongly associated with T2DM prevalence. The main risk factors were inadequate physical activity (2007: OR 1.9;95% CI:1.16–2.98 and 2013: OR 2.44;95% CI: 1.57-3.78) and central obesity (2007: OR 1.8;95% CI:0.99–3.10, and 2013:OR 3.84; 95% CI: 2.49-5.93) after controlling for age, gender, employment and economic status.<br /><br />Conclusions<br />Type 2 diabetes mellitus prevalence in the population aged &gt;15 years increased within 5 years. Lack of physical activity and central obesity were the major risk factors of T2DM prevalence in urban adults.

scholarly journals Perilaku gaya hidup dan obesitas sebagai faktor risiko kejadian diabetes melitus tipe 2 di RSUD. Aji Batara Agung Dewa Sakti Samboja Kabupaten Kutai Kartanegara

2016 ◽  
Vol 32 (12) ◽  
pp. 461
Author(s):  
Neni Sundari ◽  
Fatwa Sari Tetra Dewi ◽  
Muhammad Robikhul Ikhsan
Keyword(s):  
Physical Activity ◽  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Physical Inactivity ◽  
Central Obesity ◽  
Multivariable Analysis ◽  
Healthy Behavior

Lifestyle behavior and obesity as risk factors for the occurrence of type 2 diabetes mellitus at RSUD Aji Batara Agung Dewa Sakti Samboja, Kutai KartanegaraPurposeThe aim of this study was to determine the correlation between knowledge of healthy behavior and obesity on the occurrence of type 2 diabetes mellitus.MethodsThis research was an observational-analytical- quantitative study with a case-control design. The study subjects were selected by purposive sampling totaling 212 outpatients and inpatients in the RSUD Aji Batara Agung Desa Sakti in which 106 patients were suffering type 2 diabetes and 106 control patients that were not suffering diabetes mellitus. All subjects were between 25-64 years old.ResultsKnowledge of healthy behavior was not statistically significant in the occurrence of type 2 diabetes mellitus while in the univariable data analysis, central obesity was statistically significant. This finding was closely related to the behavior of low physical inactivity but central obesity increased with age and the prevalence was greater in women. Multivariable analysis showed that central obesity, physical inactivity (moderate physical activity and low activity) and very high incomes were the main risk factors for type 2 diabetes mellitus.ConclusionThe occurrence of type 2 diabetes mellitus in the community needs to be reduced by improving healthy lifestyles, physical activity and patterns of healthy diet, by eating fruits and vegetables, and not drinking alcohol nor smoking.

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