scholarly journals Examination of hepato-renal functions and lipid panel among pregnant women with preeclampsia in Sétif, Algeria

2020 ◽  
Author(s):  
Romyla Bourouba
Keyword(s):  
Pregnant Women ◽  
Lipid Profile ◽  
Fetal Mortality ◽  
Plasma Sodium ◽  
Targeted Prevention ◽  
Serum Aminotransferase ◽  
Renal Functions ◽  
Renal Biomarkers ◽  
Lipid Panel ◽  
Glutamyl Transferase

Preeclampsia (PE) is a multisystem pregnancy disease inflecting maternal, fetal mortality and morbidity. This case-control study aims to determine the biochemical changes in lipid profile, hepatic and renal functions among sixty preeclamptic women compared to sixty age-matching normotensive pregnant women from the Maternity Hospital in Sétif, Algeria. Several biomarkers were collected and have been determined by appropriate kits. Association between various parameters was evaluated using Pearson’s correlation coefficient, with significance at P<0.05. The PE women showed a significant increase in serum aminotransferase, gamma-glutamyl-transferase, alkaline phosphatase, as well as total cholesterol, triglycerides, urea, uric acid, and creatinine levels. However, a significant decrease in platelets, total protein, albumin, and plasma sodium levels were found in PE group. A positive correlation between aminotransferases and renal biomarkers was observed.PE has deleterious effects on liver and renal functions, and could be predicted by evaluating hepatic and renal biomarkers as well as lipid profile in the early stage of disease, for targeted prevention strategies in our population. Further studies on genetic assessment in cases of PE are needed for a better understanding of this disease’s pathophysiology in Algeria.

scholarly journals Examination of hepato-renal functions and lipid panel among pregnant women with preeclampsia in Sétif, Algeria

2020 ◽  
Vol 93 (2) ◽  
Author(s):  
Romyla Bourouba ◽  
Kaouthar Benantar ◽  
Chaima Ayati ◽  
Lina Hedna ◽  
Kenza Gherbi ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Lipid Profile ◽  
Fetal Mortality ◽  
Plasma Sodium ◽  
Gamma Glutamyl Transferase ◽  
Serum Aminotransferase ◽  
Renal Functions ◽  
Renal Biomarkers ◽  
Lipid Panel ◽  
Glutamyl Transferase

Preeclampsia (PE) is a multisystem pregnancy disease inflecting maternal and fetal mortality and morbidity. This case-control study aims to determine the biochemical changes in lipid profile, hepatic and renal functions among sixty late-onset preeclamptic women compared to sixty age-matching normotensive pregnant women from the Maternity Hospital in Sétif, Algeria. Several biomarkers were collected and have been determined by appropriate kits. Association between various parameters was evaluated using Pearson’s correlation coefficient, with significance at p<0.05. The PE women showed a significant increase in serum aminotransferase, gamma-glutamyl-transferase, alkaline phosphatase, as well as total cholesterol, triglycerides, urea, uric acid, and creatinine levels. However, a significant decrease in platelets, total protein, albumin, and plasma sodium levels was found in PE group. A positive correlation between aminotransferases and renal biomarkers was observed. PE has deleterious effects on liver and renal functions, and complication’s progression could be predicted by evaluating hepatic and renal biomarkers as well as lipid profile. Further studies on maternal and neonatal outcomes in cases of PE are needed for a better understanding of this disease’s pathophysiology in Algeria.

scholarly journals Perfluoroalkyl substances and lipid profile in exposed pregnant women in the Veneto Region, Italy

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
T Dalla Zuanna ◽  
G Barbieri ◽  
G Pitter ◽  
M Zare Jeddi ◽  
F Daprà ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Lipid Profile ◽  
Plasma Concentrations ◽  
Density Lipoprotein ◽  
Additive Models ◽  
Lipoprotein Cholesterol ◽  
Perfluoroalkyl Substances ◽  
Surveillance Program ◽  
Veneto Region ◽  
Exposed Population

Abstract Background Perfluoroalkyl substances (PFASs) are persistent and widespread environmental pollutants. Residents of a large area of the Veneto Region (North-Eastern Italy) were exposed to high concentrations of PFASs through drinking water from the late-1970s to 2013. PFASs have been consistently associated with raised serum lipids, but only few studies have been conducted among pregnant women, and none has stratified analyses by trimesters of gestation. Our main objective was to evaluate the association between perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) levels and lipid profiles in high-exposed pregnant women. Methods A cross-sectional analysis was conducted in 319 pregnant women (age 14-48 years) recruited in the Regional health surveillance program. Serum PFASs were measured by HPLC-MS/MS. Non-fasting serum total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C) were measured by enzymatic assays in automated analysers, and low-density lipoprotein cholesterol (LDL-C) was calculated. The associations between ln-transformed PFASs (and categorized into quartiles) and lipids were assessed using generalized additive models. Analyses were adjusted for potential confounders and stratified according to pregnancy trimester. Results In the first trimester, plasma concentrations of both PFOA and PFOS were positively associated with TC. However in the third trimester PFOA levels were instead inversely significantly associated with TC and LDL-C levels. Overall, both PFOA and PFOS were positively associated with HDL-C, and PFOA negatively with LDL-C. Conclusions In a small highly exposed population of pregnant women, the associations between PFASs concentrations and lipid profile were modified by trimester of gestation. Patterns late in pregnancy were different to the positive associations with LDL-C generally found. Differential transfer and bioaccumulation of lipids and PFAS in the placenta across gestation might explain our findings. Key messages This study provides evidence of different patterns of PFAS associations with lipids in pregnant women across the trimesters of gestation. The different patterns of association from general population studies sheds light on the role of fetal nutrition during pregnancy affecting both lipids and PFAS in serum.

scholarly journals The association between perfluoroalkyl substances and lipid profile in exposed pregnant women in the Veneto region, Italy

2021 ◽  
Vol 209 ◽  
pp. 111805
Author(s):  
Teresa Dalla Zuanna ◽  
David A. Savitz ◽  
Giulia Barbieri ◽  
Gisella Pitter ◽  
Maryam Zare Jeddi ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Lipid Profile ◽  
Perfluoroalkyl Substances ◽  
Veneto Region

scholarly journals Correlation of Gamma Glutamyl Transferase with Traditional Risk Markers of Cardiovascular Disease in Different Obesity Phenotypes

2021 ◽  
Author(s):  
Amit Kumar Meena ◽  
Sonali Sharma ◽  
Barkha Gupta ◽  
Asrar Ahmed
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Lipid Profile ◽  
Liver Enzymes ◽  
Tertiary Care ◽  
Gamma Glutamyl Transferase ◽  
Strong Positive Correlation ◽  
Positive Correlation ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase

Introduction: The increased prevalence of overweight, obesity, and metabolic syndrome has revealed that liver enzymes have a potential role as determinants of metabolic conditions such as, hyperlipidemia, and Cardiovascular Disease (CVD). Aim: The study aimed to investigate the correlation between liver enzymes with anthropometric indices of obesity and lipid profile in different obese phenotypes at a tertiary care. Materials and Methods: The present observational study was conducted on a total of 180 obese participants of either gender in the age group 18-59 years from December 2018 to May 2019. These were further divided into two phenotypic groups viz., Metabolically Healthy Obese (MHO group; n=90) and Metabolically Unhealthy Obese (MUHO group; n=90) according to NCEP ATP III criteria.Traditional cardiovascular risk factors were evaluated in the study participants through anthropometric viz., Body Mass Index (BMI), Waist Circumference (WC), Hip Circumference (HC), waist–hip ratio (WHR), blood pressure and biochemical investigations i.e., serum glucose, lipid profile and liver enzymes. Data was analysed by using Microsoft excel software. Results: Among 180 obese participants, 76 were males and 104 females with mean age 40.42±10.84 years. In MUHO phenotype, Gamma Glutamyl Transferase (GGT) showed a strong positive correlation with BMI (r=0.413, p=0.00001), lipid parameters viz., LDL-C (r=0.3785, p=0.0001), TC (r=0.2953, p=0.0023), TG (r=0.2623, p=0.006) and negative correlation with HDL-C (-r=0.3167, p=0.001). No significant correlation was found in MHO phenotype between liver enzymes, BMI and lipid profile parameters. Conclusion: The results of this study indicated that GGT shows a strong positive correlation with traditional risk factors in MUHO participants. Thus, raised GGT may be considered as a risk marker of CVD in MUHO phenotype.

scholarly journals Effect of high blood pressure on thyroid and lipid profile of pregnant women

2019 ◽  
Vol 8 (9) ◽  
pp. 3699
Author(s):  
Gurpreet Kaur Gill ◽  
Mandeep Kaur ◽  
Partapbir Singh ◽  
Juhi Kataria
Keyword(s):  
Blood Pressure ◽  
Thyroid Hormone ◽  
Pregnant Women ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Medical Problem ◽  
Maternity Hospital ◽  
Thyroid Stimulating Hormone ◽  
Urine Albumin ◽  
Thyroid Profile

Background: Hypertension is common medical problem encountered during pregnancy, complicating up to 10% pregnancies. Hypertension is defined as the systolic blood pressure ≤140 mmHg and a diastolic blood pressure ≥90 mmHg on two separate measurements at least 4-6 hours apart. During pregnancy thyroid demand changes with increased iodine uptake and synthesis of thyroid hormone. Serum from pre-eclamptic women had both a higher ratio of free fatty acid to albumin and increase up take of free fatty acids, which are further esterified to triglyceride. The aim of the present study was to evaluate thyroid hormone, lipid profile and urine albumin in hypertensive pregnant women and its comparison with normotensive pregnant womenMethods: Total 90 samples were collected from Beri Maternity Hospital and Civil Hospital, Amritsar. Blood samples were analysed for biochemical parameters viz. lipid profile and thyroid profile. Urine samples were also analysed for presence of albumin.Results: From the study it has been revealed that thyroid stimulating hormone (TSH) levels increased in hypertensive pregnant women mean (4.26±1.1µ/ml). The total cholesterol (234.56±14.2mg/dl), triglyceride (138±16.96mg/dl), HDL (50.7±7.4mg/dl), LDL (156.2±17.11mg/dl) and VLDL (27.7±3mg/dl) was found altered in hypertensive pregnancy as compared to normotensive pregnancy. The albumin excretion was seen in 13.3% hypertensive pregnancies.Conclusions: TSH were elevated in hypertensive pregnant women due to the effects of estrogen. Among all the parameters of lipid profile, total cholesterol, TG, LDL and VLDL has been increased significantly in hypertensive pregnant women as compared to normotensive pregnant women due endothelial dysfunction. 

scholarly journals A study of lipid parameters among GDM and non GDM pregnant women: a hospital based study

2017 ◽  
Vol 6 (12) ◽  
pp. 5488 ◽  
Author(s):  
Bharathi K. R. ◽  
Vijayalakshmi S. ◽  
Shrunga R. P.
Keyword(s):  
Pregnant Women ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Statistical Significance ◽  
Serum Triglyceride ◽  
Normal Pregnancy ◽  
P Value ◽  
Case Group ◽  
Lipid Levels ◽  
Lipid Parameters

Background: Altered maternal lipid metabolism is common in pregnancy. In women with GDM physiological changes in insulin and lipid levels are exaggerated during pregnancy, leading to significant alterations in lipid levels compared to normal pregnancy. Assessment of raise in certain lipid parameters in pregnant women with GDM and non GDM.Methods: A hospital based case control study done in the Department of OBG AIMS Bellur, Mandya, Karnataka, with sample size of 100 pregnant women. 50 cases of GDM (confirmed by OGCT) and 50 controls (non GDM cases) pregnant women were taken during 1 year study period from June 2015 to June 2016. Mean age of presentation of women was 20-25 yrs. Ethical committee clearance was taken and consent from control and cases was taken. Fasting lipid profile was sent. Parameters obtained were analyzed using student t test for statistical significance.Results: There was no statistical difference in age and parity between control and case group. Triglyceride (cases- 286.4±77.60 mg/dl) (controls-166±26mg/dl), total cholesterol (cases-256.5±41.7 mg/dl) (controls -202.5±20.18mg/dl), VLDL (cases-53.4±13.2 mg/dl) (controls-46.6±13.1mg/dl) showed statistically significant values (p value<0.001). HDL and LDL values did not show any statistical significance (p value >0.5) among GDM and non GDM group. Lipid profile was performed predominately in women in II trimester.Conclusions: Serum triglyceride, total cholesterol and VLDL level are significantly higher among woman with GDM compared to non GDM pregnant women, where in the lipid profile can be used as predictor for gestational diabetes mellitus in future which needs further research.

Association between serum aminotransferase enzymes–lipid profile ratio and spontaneous HCV clearance in blood donors

2016 ◽  
Vol 11 (1) ◽  
pp. 19-29 ◽  
Author(s):  
Ashraf A Tabll ◽  
Marwa A Kodous ◽  
Ayman T Abbas ◽  
Mohamed M Omran ◽  
Elsherbeny H Elsayed
Keyword(s):  
Lipid Profile ◽  
Blood Donors ◽  
Serum Aminotransferase ◽  
Spontaneous Hcv Clearance
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