scholarly journals Examination of hepato-renal functions and lipid panel among pregnant women with preeclampsia in Sétif, Algeria

2020 ◽  
Vol 93 (2) ◽  
Author(s):  
Romyla Bourouba ◽  
Kaouthar Benantar ◽  
Chaima Ayati ◽  
Lina Hedna ◽  
Kenza Gherbi ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Lipid Profile ◽  
Fetal Mortality ◽  
Plasma Sodium ◽  
Gamma Glutamyl Transferase ◽  
Serum Aminotransferase ◽  
Renal Functions ◽  
Renal Biomarkers ◽  
Lipid Panel ◽  
Glutamyl Transferase

Preeclampsia (PE) is a multisystem pregnancy disease inflecting maternal and fetal mortality and morbidity. This case-control study aims to determine the biochemical changes in lipid profile, hepatic and renal functions among sixty late-onset preeclamptic women compared to sixty age-matching normotensive pregnant women from the Maternity Hospital in Sétif, Algeria. Several biomarkers were collected and have been determined by appropriate kits. Association between various parameters was evaluated using Pearson’s correlation coefficient, with significance at p<0.05. The PE women showed a significant increase in serum aminotransferase, gamma-glutamyl-transferase, alkaline phosphatase, as well as total cholesterol, triglycerides, urea, uric acid, and creatinine levels. However, a significant decrease in platelets, total protein, albumin, and plasma sodium levels was found in PE group. A positive correlation between aminotransferases and renal biomarkers was observed. PE has deleterious effects on liver and renal functions, and complication’s progression could be predicted by evaluating hepatic and renal biomarkers as well as lipid profile. Further studies on maternal and neonatal outcomes in cases of PE are needed for a better understanding of this disease’s pathophysiology in Algeria.

scholarly journals Examination of hepato-renal functions and lipid panel among pregnant women with preeclampsia in Sétif, Algeria

2020 ◽  
Author(s):  
Romyla Bourouba
Keyword(s):  
Pregnant Women ◽  
Lipid Profile ◽  
Fetal Mortality ◽  
Plasma Sodium ◽  
Targeted Prevention ◽  
Serum Aminotransferase ◽  
Renal Functions ◽  
Renal Biomarkers ◽  
Lipid Panel ◽  
Glutamyl Transferase

Preeclampsia (PE) is a multisystem pregnancy disease inflecting maternal, fetal mortality and morbidity. This case-control study aims to determine the biochemical changes in lipid profile, hepatic and renal functions among sixty preeclamptic women compared to sixty age-matching normotensive pregnant women from the Maternity Hospital in Sétif, Algeria. Several biomarkers were collected and have been determined by appropriate kits. Association between various parameters was evaluated using Pearson’s correlation coefficient, with significance at P<0.05. The PE women showed a significant increase in serum aminotransferase, gamma-glutamyl-transferase, alkaline phosphatase, as well as total cholesterol, triglycerides, urea, uric acid, and creatinine levels. However, a significant decrease in platelets, total protein, albumin, and plasma sodium levels were found in PE group. A positive correlation between aminotransferases and renal biomarkers was observed.PE has deleterious effects on liver and renal functions, and could be predicted by evaluating hepatic and renal biomarkers as well as lipid profile in the early stage of disease, for targeted prevention strategies in our population. Further studies on genetic assessment in cases of PE are needed for a better understanding of this disease’s pathophysiology in Algeria.

scholarly journals Correlation of Gamma Glutamyl Transferase with Traditional Risk Markers of Cardiovascular Disease in Different Obesity Phenotypes

2021 ◽  
Author(s):  
Amit Kumar Meena ◽  
Sonali Sharma ◽  
Barkha Gupta ◽  
Asrar Ahmed
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Lipid Profile ◽  
Liver Enzymes ◽  
Tertiary Care ◽  
Gamma Glutamyl Transferase ◽  
Strong Positive Correlation ◽  
Positive Correlation ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase

Introduction: The increased prevalence of overweight, obesity, and metabolic syndrome has revealed that liver enzymes have a potential role as determinants of metabolic conditions such as, hyperlipidemia, and Cardiovascular Disease (CVD). Aim: The study aimed to investigate the correlation between liver enzymes with anthropometric indices of obesity and lipid profile in different obese phenotypes at a tertiary care. Materials and Methods: The present observational study was conducted on a total of 180 obese participants of either gender in the age group 18-59 years from December 2018 to May 2019. These were further divided into two phenotypic groups viz., Metabolically Healthy Obese (MHO group; n=90) and Metabolically Unhealthy Obese (MUHO group; n=90) according to NCEP ATP III criteria.Traditional cardiovascular risk factors were evaluated in the study participants through anthropometric viz., Body Mass Index (BMI), Waist Circumference (WC), Hip Circumference (HC), waist–hip ratio (WHR), blood pressure and biochemical investigations i.e., serum glucose, lipid profile and liver enzymes. Data was analysed by using Microsoft excel software. Results: Among 180 obese participants, 76 were males and 104 females with mean age 40.42±10.84 years. In MUHO phenotype, Gamma Glutamyl Transferase (GGT) showed a strong positive correlation with BMI (r=0.413, p=0.00001), lipid parameters viz., LDL-C (r=0.3785, p=0.0001), TC (r=0.2953, p=0.0023), TG (r=0.2623, p=0.006) and negative correlation with HDL-C (-r=0.3167, p=0.001). No significant correlation was found in MHO phenotype between liver enzymes, BMI and lipid profile parameters. Conclusion: The results of this study indicated that GGT shows a strong positive correlation with traditional risk factors in MUHO participants. Thus, raised GGT may be considered as a risk marker of CVD in MUHO phenotype.

scholarly journals Effects of change in body weight on serum aminotransferase and gamma-glutamyl transferase levels.

Sangyo Igaku ◽  
1993 ◽  
Vol 35 (1) ◽  
pp. 36-37
Author(s):  
Yutaka TAKASHIMA ◽  
Takashi AKAMATSU ◽  
Yasuhide ORIDO ◽  
Takaaki KINOUE
Keyword(s):  
Body Weight ◽  
Gamma Glutamyl Transferase ◽  
Serum Aminotransferase ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase

scholarly journals Ursodeoxycholic Acid and Atorvastatin in the Treatment of Nonalcoholic Steatohepatitis

2003 ◽  
Vol 17 (12) ◽  
pp. 713-718 ◽  
Author(s):  
Murat Kiyici ◽  
Macit Gulten ◽  
Selim Gurel ◽  
Selim Giray Nak ◽  
Enver Dolar ◽  
...  
Keyword(s):  
Ursodeoxycholic Acid ◽  
Treatment Period ◽  
Nonalcoholic Steatohepatitis ◽  
Liver Steatosis ◽  
Gamma Glutamyl Transferase ◽  
Serum Aminotransferase ◽  
History Of ◽  
Group 2 ◽  
Glutamyl Transferase ◽  
Group 1

BACKGROUND/AIMS: Nonalcoholic steatohepatitis (NASH) is a serious disorder with the potential to gradually progress to cirrhosis. It is generally associated with obesity, diabetes and hyperlipidemia. Currently, there is no established therapy for NASH. The aim of the present study was to evaluate the effectiveness of atorvastatin and ursodeoxycholic acid (UDCA) in the treatment of NASH.METHODS: This prospective study included 44 adult patients (24 men, 20 women) with a mean age of 48.90±7.69 years and mean body mass index (BMI) of 29.40±3.82. Ten patients had a history of diabetes. Serological markers for viral hepatitis were negative in all patients and there was no history of alcohol or drug abuse. Patients who had autoimmune hepatitis were excluded from the study. Liver biopsy was performed before therapy to confirm the diagnosis. Among NASH patients, 17 normolipidemic cases received UDCA 13 to 15 mg/kg/day (group 1), while hyperlipidemic cases (n=27) received atorvastatin 10 mg/day (group 2) for six months. The BMI, serum lipids, liver function tests and liver density, assessed by computerized tomography, were evaluated before and after the treatment period. The BMI, serum aminotransferase levels, histological parameters (steatosis, inflammation, fibrosis scores) and liver densities were not statistically different between the groups at the beginning of therapy.RESULTS: The BMI, serum glucose, and triglyceride levels did not change in either group after the treatment period. In group 1, serum alanine aminotransferase (ALT) and gamma-glutamyl-transferase (GGT) levels reduced significantly, and in group 2, serum cholesterol, aspartate aminotransferase, ALT, alkaline phosphatase and GGT levels reduced significantly. Liver densities increased only in group 2, probably as a result of diminishing fat content of liver. The normalization of transaminases was also more prevalent in group 2. Liver steatosis was closely correlated with liver density, but inflammation and fibrosis were not.CONCLUSIONS: The use of atorvastatin in NASH patients with hyperlipidemia was found to be both effective and safe. The benefit of statin and UDCA therapy in normolipidemic patients with NASH requires confirmation with further placebo-controlled trials.

scholarly journals The Effect of dietary induced hypercholesterolemia on the lipid profile and some enzyme activities in Wistar male rats.

2017 ◽  
Vol 1 (2) ◽  
Author(s):  
El-Khedr Mohamed Mostafa El-gamal
Keyword(s):  
Soybean Oil ◽  
Lipid Profile ◽  
Density Lipoprotein ◽  
Male Rats ◽  
Gamma Glutamyl Transferase ◽  
Significant Difference ◽  
Aspartate Amino Transferase ◽  
Male Wistar Rats ◽  
Normal Rat ◽  
Glutamyl Transferase

Aim of study: To investigate the effects of high dietary soybean oil and cholesterol on the serum lipid profile, enzymes and biochemical changes in weanling Wistar rat’s male. Materials and Methods: Twenty weanling male Wistar rats organised equaliy into two groups were used in this study. The first group of rats, were fed with controlled diet made up of the normal rat chow (C), and the second group was fed with hypercholesterolemia diet (HPC) enriched with 25% soybean oil and 1% cholesterol for eight weeks.  Results: The dietary intake of the HPC diet was significantly increased the level of total cholesterol (TC), LDL-C and triglycerides (TG) in the serum of Wister rats fed with HPC diet. gamma glutamyl transferase (GGT), aspartate amino transferase (AST) and alanine amino transferase (ALT), activities were also markedly elevated in rats fed with HPC diet; while, total protein and glucose level of rats fed with HPC diet was remarkably reduced, no significant difference was found in the high density lipoprotein cholesterol (HDL-C) and albumin contents of both groups.  Conclusion: This study established that hypercholesterolemia is induced by high soybean oil/cholesterol diet, despite the fact that soybean oil has high content of polyunsaturated fatty acids.  In addition, the HPC diet led to weight loss in the rats and caused injury of rats’ heart and liver.

scholarly journals Association between Liver Enzymes and Dyslipidemia in Yemeni Patients with Type Two Diabetes Mellitus

2021 ◽  
Author(s):  
Lotfi S. Bin Dahman ◽  
Mariam A. Humam ◽  
Omer M. Barahman
Keyword(s):  
Diabetes Mellitus ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Liver Enzymes ◽  
Pearson Correlation ◽  
Fasting Blood Glucose ◽  
Gamma Glutamyl Transferase ◽  
Chronic Hyperglycemia ◽  
Glutamyl Transferase ◽  
Type Two Diabetes

Abstract Type two diabetes mellitus (T2DM) is characterized by chronic hyperglycemia and is associated with dyslipidemia and liver function disorders. This study was conducted to assess the association between liver enzymes and elevated lipid profile in a sample of Yemeni patients with T2DM. A case-control study comprising 142 T2D patients and 142 healthy control subjects was carried out at the outpatient clinics of Ibn-Sina hospital, Mukalla, during the period from January to May 2020. Serum fasting blood glucose (FBG), total cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL-C), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transferase (GGT) were analyzed using the Cobas Integra Plus 400 autoanalyzer. Also, anthropometric and blood pressure measurements were taken from each participant. Independent sample T-test and Pearson correlation coefficient were used. T2D patients had significantly higher FBG (P= <0.0001), total cholesterol (P= <0.0001), LDL-C (P= <0.0001), and GGT (P= <0.0001) while, HDL-C was significantly lower in T2D patients (P= 0.021). In correlation analysis, serum GGT was positively associated with FBG (r= 0.216; P= <0.0001), total cholesterol (r= 0.196; P= 0.0001), triglyceride (r= 0.123; P= 0.038), and LDL-C (r= 0.209; P= <0.0001). Also, serum ALT was positively associated with FBG (r= 0.145, P= 0.014) and triglyceride (r= 0.172, P= 0.004). In conclusion, higher levels of ALT and GGT are used as the predictive biomarkers for NAFLD in T2D patients with hyperlipidemia. Thus, routine screening of liver enzymes and lipid profile in T2D patients is recommended for the early detection of liver abnormalities and diminish diabetes complications.

scholarly journals Gamma-glutamyl transferase is an indicator of gestational diabetes mellitus

2016 ◽  
Vol 44 (3) ◽  
pp. 152-156 ◽  
Author(s):  
Mousumi Ghosh ◽  
Debatosh Paul ◽  
Md Saiful Islam ◽  
Gopal Chandra Ghosh ◽  
Mohammad Monzurul Alam Bhuiyan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Obstetrics And Gynecology ◽  
Gamma Glutamyl Transferase ◽  
Cross Sectional ◽  
Gamma Glutamyl ◽  
Group I ◽  
Glutamyl Transferase

Increased gamma-glutamyl transferase (GGT) is associated with gestational diabetes mellitus (GDM) and type 2 diabetes mellitus in pregnant women. This cross sectional study was conducted in the Department of Clinical Pathology in collaboration with Department of Obstetrics and Gynecology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka from March 2014 to February 2015 to assess the GGT as an indicator of GDM. Total 66 pregnant women were enrolled in this study in the Department of Obstetrics and Gynecology, BSMMU. Total 33 cases were considered as Group I (GDM) and 33 controls were Group II (normal healthy pregnant women). Two ml of blood was collected in plain test tube from each patient. Gestational diabetes mellitus were diagnosed by FBS and 2hr after 75g glucose in this study as cases. Normal healthy pregnant women was included in this study as control. GGT was higher in GDM group compared to normal healthy pregnant women (30.60±7.78 vs. 16.45±4.97, p<0.001). So, with the help of GGT we can take preventive measure and precaution to reduce the risk of GDM in pregnant women.Bangladesh Med J. 2015 Sep; 44 (3): 152-156

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