scholarly journals Cutting Edge: Failure of Antigen-Specific CD4+ T Cell Recruitment to the Kidney during Systemic Candidiasis

2014 ◽  
Vol 193 (11) ◽  
pp. 5381-5385 ◽  
Author(s):  
Rebecca A. Drummond ◽  
Carol Wallace ◽  
Delyth M. Reid ◽  
Sing Sing Way ◽  
Daniel H. Kaplan ◽  
...  
Keyword(s):  
T Cell ◽  
Cutting Edge ◽  
Cd4 T Cell ◽  
Systemic Candidiasis ◽  
Cell Recruitment ◽  
Edge Failure

Proinflammatory Oscillations Over the Menstrual Cycle Drives Bystander CD4 T Cell Recruitment and SHIV Susceptibility from Vaginal Challenge

2021 ◽  
Author(s):  
Alison Swaims-Kohlmeier ◽  
Jed Brody ◽  
Anandi Sheth ◽  
Felicia P. Hardnett ◽  
Sunita Sharma ◽  
...  
Keyword(s):  
T Cell ◽  
Menstrual Cycle ◽  
Cd4 T Cell ◽  
Cell Recruitment

scholarly journals Cutting Edge: Novel Priming of Tumor-Specific Immunity by NKG2D-Triggered NK Cell-Mediated Tumor Rejection and Th1-Independent CD4+ T Cell Pathway

2004 ◽  
Vol 172 (2) ◽  
pp. 757-761 ◽  
Author(s):  
Jennifer A. Westwood ◽  
Janice M. Kelly ◽  
Jane E. Tanner ◽  
Michael H. Kershaw ◽  
Mark J. Smyth ◽  
...  
Keyword(s):  
T Cell ◽  
Nk Cell ◽  
Cutting Edge ◽  
Tumor Rejection ◽  
Cd4 T Cell ◽  
Specific Immunity

Both Stat5a and Stat5b are required for antigen-induced eosinophil and T-cell recruitment into the tissue

Blood ◽  
2000 ◽  
Vol 95 (4) ◽  
pp. 1370-1377 ◽  
Author(s):  
Shin-ichiro Kagami ◽  
Hiroshi Nakajima ◽  
Kotaro Kumano ◽  
Kotaro Suzuki ◽  
Akira Suto ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cd4 T Cells ◽  
Specific Ige ◽  
Cd4 T Cell ◽  
Cell Infiltration ◽  
Cell Recruitment ◽  
Eosinophil Recruitment ◽  
Airway Eosinophilia ◽  
T Cell Infiltration

Antigen-induced eosinophil recruitment into the airways of sensitized mice is mediated by CD4+ T cells and their cytokines, especially IL-5. In this study, we found that the antigen-induced airway eosinophilia was diminished in Stat5a-deficient (Stat5a−/−) mice and Stat5b-deficient (Stat5b−/−) mice. We also found that antigen-induced CD4+ T-cell infiltration and IL-5 production in the airways were diminished in Stat5a−/− mice and Stat5b−/− mice. Moreover, antigen-induced proliferation of splenocytes was diminished in Stat5a−/− mice and Stat5b−/− mice, suggesting that the generation of antigen-primed T cells may be compromised in Stat5a−/−mice and Stat5b−/− mice and this defect may account for the diminished antigen-induced T-cell infiltration into the airways. Interestingly, IL-4 and IL-5 production from anti-CD3–stimulated splenocytes was diminished in Stat5a−/− mice and Stat5b−/− mice. However, antigen-specific IgE and IgG1 production was diminished in Stat5a−/− mice but not in Stat5b−/− mice, whereas antigen-specific IgG2a production was increased in Stat5a−/− mice, suggesting the enhanced Th1 responses in Stat5a−/− mice. Finally, we found that eosinophilopoiesis induced by the administration of recombinant IL-5 was also diminished in Stat5a−/− mice and Stat5b−/− mice. Together, these results indicate that both Stat5a and Stat5b are essential for induction of antigen-induced eosinophil recruitment into the airways and that the defects in antigen-induced eosinophil recruitment in Stat5a−/− mice and Stat5b−/− mice result from both impaired IL-5 production in the airways and diminished IL-5 responsiveness of eosinophils.

scholarly journals Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

2011 ◽  
Vol 186 (6) ◽  
pp. 3299-3303 ◽  
Author(s):  
Ryan D. Michalek ◽  
Valerie A. Gerriets ◽  
Sarah R. Jacobs ◽  
Andrew N. Macintyre ◽  
Nancie J. MacIver ◽  
...  
Keyword(s):  
T Cell ◽  
Cutting Edge ◽  
T Cell Subsets ◽  
Cd4 T Cell
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