Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

The Journal of Immunology ◽

10.4049/jimmunol.1003613 ◽

2011 ◽

Vol 186 (6) ◽

pp. 3299-3303 ◽

Cited By ~ 948

Author(s):

Ryan D. Michalek ◽

Valerie A. Gerriets ◽

Sarah R. Jacobs ◽

Andrew N. Macintyre ◽

Nancie J. MacIver ◽

...

Keyword(s):

T Cell ◽

Cutting Edge ◽

T Cell Subsets ◽

Cd4 T Cell

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Faculty Opinions recommendation of Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.10688957.793531683 ◽

2017 ◽

Author(s):

Luisa Figueiredo

Keyword(s):

T Cell ◽

Cutting Edge ◽

T Cell Subsets ◽

Cd4 T Cell

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Faculty Opinions recommendation of Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.10688957.11577055 ◽

2011 ◽

Author(s):

Andrew Weinberg

Keyword(s):

T Cell ◽

Cutting Edge ◽

T Cell Subsets ◽

Cd4 T Cell

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Faculty Opinions recommendation of Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.10688957.15779325 ◽

2012 ◽

Author(s):

Douglas Green

Keyword(s):

T Cell ◽

Cutting Edge ◽

T Cell Subsets ◽

Cd4 T Cell

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Cutting Edge: T Cell–Dependent Plasmablasts Form in the Absence of Single Differentiated CD4+ T Cell Subsets

The Journal of Immunology ◽

10.4049/jimmunol.1801349 ◽

2018 ◽

Vol 202 (2) ◽

pp. 401-405 ◽

Cited By ~ 3

Author(s):

Jessica A. Kotov ◽

Marc K. Jenkins

Keyword(s):

T Cell ◽

Cutting Edge ◽

T Cell Subsets ◽

Cd4 T Cell

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Functional CD4 T cell subsets activity in C57BL/10 mice with inherited low IgG responsiveness

Immunology Letters ◽

10.1016/s0165-2478(97)87728-0 ◽

1997 ◽

Vol 56 (1-3) ◽

pp. 223

Author(s):

B RÃhovÃ¡

Keyword(s):

T Cell ◽

T Cell Subsets ◽

Cd4 T Cell

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Faculty Opinions recommendation of Cutting edge: CD4 T cell-mast cell interactions alter IgE receptor expression and signaling.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1101097.558073 ◽

2008 ◽

Author(s):

Antony Basten

Keyword(s):

Mast Cell ◽

T Cell ◽

Cell Interactions ◽

Cutting Edge ◽

Receptor Expression ◽

Cd4 T Cell ◽

Ige Receptor

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Faculty Opinions recommendation of Cutting edge: Experimentally induced immune activation in natural hosts of simian immunodeficiency virus induces significant increases in viral replication and CD4+ T cell depletion.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1138020.595135 ◽

2008 ◽

Author(s):

Christopher Miller ◽

Meritxell Genescà

Keyword(s):

T Cell ◽

Viral Replication ◽

Simian Immunodeficiency Virus ◽

Immune Activation ◽

Cutting Edge ◽

Cd4 T Cell ◽

Cell Depletion ◽

T Cell Depletion ◽

Immunodeficiency Virus ◽

Natural Hosts

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Faculty Opinions recommendation of Cutting edge: Conditional MHC class II expression reveals a limited role for B cell antigen presentation in primary and secondary CD4 T cell responses.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718020496.793480946 ◽

2013 ◽

Author(s):

Tim Manser

Keyword(s):

T Cell ◽

B Cell ◽

Antigen Presentation ◽

Mhc Class Ii ◽

T Cell Responses ◽

Class Ii ◽

Cutting Edge ◽

Cd4 T Cell ◽

Cell Antigen ◽

Cell Responses

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Faculty Opinions recommendation of Cutting edge: Failure of antigen-specific CD4+ T cell recruitment to the kidney during systemic candidiasis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.723891812.793501430 ◽

2014 ◽

Author(s):

Sarah Gaffen

Keyword(s):

T Cell ◽

Cutting Edge ◽

Cd4 T Cell ◽

Systemic Candidiasis ◽

Cell Recruitment ◽

Edge Failure

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Traditional Thai Massage Promoted Immunity in the Elderly via Attenuation of Senescent CD4+ T Cell Subsets: A Randomized Crossover Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18063210 ◽

2021 ◽

Vol 18 (6) ◽

pp. 3210

Author(s):

Kanda Sornkayasit ◽

Amonrat Jumnainsong ◽

Wisitsak Phoksawat ◽

Wichai Eungpinichpong ◽

Chanvit Leelayuwat

Keyword(s):

T Cells ◽

T Cell ◽

Crossover Study ◽

Intracellular Cytokine Staining ◽

The Elderly ◽

Complementary Therapy ◽

T Cell Subsets ◽

Cd4 T Cell ◽

T Subsets ◽

Randomized Crossover Study

The beneficial physiological effects of traditional Thai massage (TTM) have been previously documented. However, its effect on immune status, particularly in the elderly, has not been explored. This study aimed to investigate the effects of multiple rounds of TTM on senescent CD4+ T cell subsets in the elderly. The study recruited 12 volunteers (61–75 years), with senescent CD4+ T cell subsets, who received six weekly 1-h TTM sessions or rest, using a randomized controlled crossover study with a 30-day washout period. Flow cytometry analysis of surface markers and intracellular cytokine staining was performed. TTM could attenuate the senescent CD4+ T cell subsets, especially in CD4+28null NKG2D+ T cells (n = 12; p < 0.001). The participants were allocated into two groups (low < 2.75% or high ≥ 2.75%) depending on the number of CD4+28null NKG2D+ T cells. After receiving TTM over 6 sessions, the cell population of the high group had significantly decreased (p < 0.001), but the low group had no significant changes. In conclusion, multiple rounds of TTM may promote immunity through the attenuation of aberrant CD4+ T subsets. TTM may be provided as a complementary therapy to improve the immune system in elderly populations.

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