Proinflammatory Oscillations Over the Menstrual Cycle Drives Bystander CD4 T Cell Recruitment and SHIV Susceptibility from Vaginal Challenge

2021 ◽  
Author(s):  
Alison Swaims-Kohlmeier ◽  
Jed Brody ◽  
Anandi Sheth ◽  
Felicia P. Hardnett ◽  
Sunita Sharma ◽  
...  
Keyword(s):  
T Cell ◽  
Menstrual Cycle ◽  
Cd4 T Cell ◽  
Cell Recruitment

scholarly journals Proinflammatory oscillations over the menstrual cycle drives bystander CD4 T cell recruitment and SHIV susceptibility from vaginal challenge

EBioMedicine ◽  
2021 ◽  
Vol 69 ◽  
pp. 103472
Author(s):  
Alison Swaims-Kohlmeier ◽  
Anandi N. Sheth ◽  
Jed Brody ◽  
Felicia P. Hardnett ◽  
Sunita Sharma ◽  
...  
Keyword(s):  
T Cell ◽  
Menstrual Cycle ◽  
Cd4 T Cell ◽  
Cell Recruitment

Both Stat5a and Stat5b are required for antigen-induced eosinophil and T-cell recruitment into the tissue

Blood ◽  
2000 ◽  
Vol 95 (4) ◽  
pp. 1370-1377 ◽  
Author(s):  
Shin-ichiro Kagami ◽  
Hiroshi Nakajima ◽  
Kotaro Kumano ◽  
Kotaro Suzuki ◽  
Akira Suto ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cd4 T Cells ◽  
Specific Ige ◽  
Cd4 T Cell ◽  
Cell Infiltration ◽  
Cell Recruitment ◽  
Eosinophil Recruitment ◽  
Airway Eosinophilia ◽  
T Cell Infiltration

Antigen-induced eosinophil recruitment into the airways of sensitized mice is mediated by CD4+ T cells and their cytokines, especially IL-5. In this study, we found that the antigen-induced airway eosinophilia was diminished in Stat5a-deficient (Stat5a−/−) mice and Stat5b-deficient (Stat5b−/−) mice. We also found that antigen-induced CD4+ T-cell infiltration and IL-5 production in the airways were diminished in Stat5a−/− mice and Stat5b−/− mice. Moreover, antigen-induced proliferation of splenocytes was diminished in Stat5a−/− mice and Stat5b−/− mice, suggesting that the generation of antigen-primed T cells may be compromised in Stat5a−/−mice and Stat5b−/− mice and this defect may account for the diminished antigen-induced T-cell infiltration into the airways. Interestingly, IL-4 and IL-5 production from anti-CD3–stimulated splenocytes was diminished in Stat5a−/− mice and Stat5b−/− mice. However, antigen-specific IgE and IgG1 production was diminished in Stat5a−/− mice but not in Stat5b−/− mice, whereas antigen-specific IgG2a production was increased in Stat5a−/− mice, suggesting the enhanced Th1 responses in Stat5a−/− mice. Finally, we found that eosinophilopoiesis induced by the administration of recombinant IL-5 was also diminished in Stat5a−/− mice and Stat5b−/− mice. Together, these results indicate that both Stat5a and Stat5b are essential for induction of antigen-induced eosinophil recruitment into the airways and that the defects in antigen-induced eosinophil recruitment in Stat5a−/− mice and Stat5b−/− mice result from both impaired IL-5 production in the airways and diminished IL-5 responsiveness of eosinophils.

scholarly journals Tpl2 Promotes Innate Cell Recruitment and Effector T Cell Differentiation To Limit Citrobacter rodentium Burden and Dissemination

2017 ◽  
Vol 85 (10) ◽  
Author(s):  
Nicole V. Acuff ◽  
Xin Li ◽  
Krishna Latha ◽  
Tamas Nagy ◽  
Wendy T. Watford
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cell Function ◽  
Immune Cell ◽  
Cd4 T Cell ◽  
Citrobacter Rodentium ◽  
Wild Type ◽  
Content Type ◽  
Cell Recruitment ◽  
Ifn Γ

ABSTRACT Tumor progression locus 2 (Tpl2) is a serine-threonine kinase that regulates Th1 differentiation, secretion of the inflammatory cytokine gamma interferon (IFN-γ), and host defense against the intracellular pathogens Toxoplasma gondii, Listeria monocytogenes, and Mycobacterium tuberculosis. However, relatively little is known about the contribution of Tpl2 to Th17 differentiation and immune cell function during infection with an extracellular pathogen. The goal of this study was to determine whether Tpl2 influences the immune response generated to the extracellular bacterium Citrobacter rodentium, which induces a mixed Th1 and Th17 response. During peak infection with C. rodentium, Tpl2 −/− mice experienced greater bacterial burdens with evidence of dissemination to the liver and spleen but ultimately cleared the bacteria within 3 weeks postinfection, similar to the findings for wild-type mice. Tpl2 −/− mice also recruited fewer neutrophils and monocytes to the colon during peak infection, which correlated with increased bacterial burdens. In mixed bone marrow chimeras, Tpl2 was shown to play a T cell-intrinsic role in promoting both IFN-γ and interleukin-17A production during infection with C. rodentium. However, upon CD4 T cell transfer into Rag −/− mice, Tpl2 −/− CD4 T cells were as protective as wild-type CD4 T cells against the dissemination of bacteria and mortality. These data indicate that the enhanced bacterial burdens in Tpl2 −/− mice are not caused primarily by impairments in CD4 T cell function but result from defects in innate immune cell recruitment and function.

scholarly journals Cutting Edge: Failure of Antigen-Specific CD4+ T Cell Recruitment to the Kidney during Systemic Candidiasis

2014 ◽  
Vol 193 (11) ◽  
pp. 5381-5385 ◽  
Author(s):  
Rebecca A. Drummond ◽  
Carol Wallace ◽  
Delyth M. Reid ◽  
Sing Sing Way ◽  
Daniel H. Kaplan ◽  
...  
Keyword(s):  
T Cell ◽  
Cutting Edge ◽  
Cd4 T Cell ◽  
Systemic Candidiasis ◽  
Cell Recruitment ◽  
Edge Failure

scholarly journals Abscisic acid ameliorates atherosclerosis by suppressing macrophage and CD4+ T cell recruitment into the aortic wall

2010 ◽  
Vol 21 (12) ◽  
pp. 1178-1185 ◽  
Author(s):  
Amir J. Guri ◽  
Sarah A. Misyak ◽  
Raquel Hontecillas ◽  
Alyssa Hasty ◽  
Dongmin Liu ◽  
...  
Keyword(s):  
Abscisic Acid ◽  
T Cell ◽  
Aortic Wall ◽  
Cd4 T Cell ◽  
Cell Recruitment

scholarly journals Antigen-specific and non-specific CD4+ T cell recruitment and proliferation during influenza infection

Virology ◽  
2005 ◽  
Vol 340 (2) ◽  
pp. 296-306 ◽  
Author(s):  
Timothy J. Chapman ◽  
Maria R. Castrucci ◽  
Ryan C. Padrick ◽  
Linda M. Bradley ◽  
David J. Topham
Keyword(s):  
T Cell ◽  
Influenza Infection ◽  
Cd4 T Cell ◽  
Cell Recruitment

scholarly journals Blocking integrin α4β7-mediated CD4 T cell recruitment to the intestine and liver protects mice from western diet-induced non-alcoholic steatohepatitis

2020 ◽  
Vol 73 (5) ◽  
pp. 1013-1022 ◽  
Author(s):  
Ravi P. Rai ◽  
Yunshan Liu ◽  
Smita S. Iyer ◽  
Silvia Liu ◽  
Biki Gupta ◽  
...  
Keyword(s):  
T Cell ◽  
Western Diet ◽  
Cd4 T Cell ◽  
Cell Recruitment ◽  
Alcoholic Steatohepatitis
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