scholarly journals Targeting CD137 Enhances Vaccine-Elicited Anti–Respiratory Syncytial Virus CD8+ T Cell Responses in Aged Mice

2013 ◽  
Vol 192 (1) ◽  
pp. 293-299 ◽  
Author(s):  
Sujin Lee ◽  
Robert S. Mittler ◽  
Martin L. Moore
Keyword(s):  
Respiratory Syncytial Virus ◽  
T Cell ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Aged Mice ◽  
Cell Responses ◽  
Syncytial Virus

scholarly journals Characterization of the CD8+ T cell responses directed against respiratory syncytial virus during primary and secondary infection in C57BL/6 mice

Virology ◽  
2006 ◽  
Vol 352 (1) ◽  
pp. 157-168 ◽  
Author(s):  
Michaël V. Lukens ◽  
Erwin A.W. Claassen ◽  
Patricia M.A. de Graaff ◽  
Mariska E.A. van Dijk ◽  
Peter Hoogerhout ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
T Cell ◽  
Secondary Infection ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Cell Responses ◽  
Syncytial Virus

scholarly journals Gene-gun DNA vaccination aggravates respiratory syncytial virus-induced pneumonitis

2004 ◽  
Vol 85 (10) ◽  
pp. 3017-3026 ◽  
Author(s):  
Christina Bartholdy ◽  
Wieslawa Olszewska ◽  
Anette Stryhn ◽  
Allan Randrup Thomsen ◽  
Peter J. M. Openshaw
Keyword(s):  
Weight Loss ◽  
Respiratory Syncytial Virus ◽  
T Cell ◽  
T Cell Responses ◽  
Dna Vaccination ◽  
T Cell Memory ◽  
Gene Gun ◽  
Cell Responses ◽  
Virus Clearance ◽  
Syncytial Virus

A CD8+ T-cell memory response to respiratory syncytial virus (RSV) was generated by using a DNA vaccine construct encoding the dominant Kd-restricted epitope from the viral transcription anti-terminator protein M2 (M282–90), linked covalently to human β 2-microglobulin (β 2m). Cutaneous gene-gun immunization of BALB/c mice with this construct induced an antigen-specific CD8+ T-cell memory. After intranasal RSV challenge, accelerated CD8+ T-cell responses were observed in pulmonary lymph nodes and virus clearance from the lungs was enhanced. The construct induced weaker CD8+ T-cell responses than those elicited with recombinant vaccinia virus expressing the complete RSV M2 protein, but stronger than those induced by a similar DNA construct without the β 2m gene. DNA vaccination led to enhanced pulmonary disease after RSV challenge, with increased weight loss and cell recruitment to the lung. Depletion of CD8+ T cells reduced, but did not abolish, enhancement of disease. Mice vaccinated with a construct encoding a class I-restricted lymphocytic choriomeningitis virus epitope and β 2m suffered more severe weight loss after RSV infection than unvaccinated RSV-infected mice, although RSV-specific CD8+ T-cell responses were not induced. Thus, in addition to specific CD8+ T cell-mediated immunopathology, gene-gun DNA vaccination causes non-specific enhancement of RSV disease without affecting virus clearance.

scholarly journals Augmentation of Primary Influenza A Virus-Specific CD8+T Cell Responses in Aged Mice through Blockade of an Immunoinhibitory Pathway

2010 ◽  
Vol 184 (10) ◽  
pp. 5475-5484 ◽  
Author(s):  
Lauren DiMenna ◽  
Brian Latimer ◽  
Elizabeth Parzych ◽  
Larissa H. Haut ◽  
Katrin Töpfer ◽  
...  
Keyword(s):  
T Cell ◽  
Influenza A Virus ◽  
Influenza A ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Aged Mice ◽  
Cell Responses
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