scholarly journals Augmentation of Primary Influenza A Virus-Specific CD8+T Cell Responses in Aged Mice through Blockade of an Immunoinhibitory Pathway

2010 ◽  
Vol 184 (10) ◽  
pp. 5475-5484 ◽  
Author(s):  
Lauren DiMenna ◽  
Brian Latimer ◽  
Elizabeth Parzych ◽  
Larissa H. Haut ◽  
Katrin Töpfer ◽  
...  
Keyword(s):  
T Cell ◽  
Influenza A Virus ◽  
Influenza A ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Aged Mice ◽  
Cell Responses

Nucleoprotein of influenza A virus is a major target of immunodominant CD8 + T‐cell responses

2013 ◽  
Vol 91 (2) ◽  
pp. 184-194 ◽  
Author(s):  
Emma Grant ◽  
Chao Wu ◽  
Kok‐Fei Chan ◽  
Sidonia Eckle ◽  
Mandvi Bharadwaj ◽  
...  
Keyword(s):  
T Cell ◽  
Influenza A Virus ◽  
Influenza A ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Cell Responses ◽  
Major Target

scholarly journals T cell immunoglobulin and mucin protein-3 (Tim-3)/Galectin-9 interaction regulates influenza A virus-specific humoral and CD8 T-cell responses

2011 ◽  
Vol 108 (47) ◽  
pp. 19001-19006 ◽  
Author(s):  
S. Sharma ◽  
A. Sundararajan ◽  
A. Suryawanshi ◽  
N. Kumar ◽  
T. Veiga-Parga ◽  
...  
Keyword(s):  
T Cell ◽  
Influenza A Virus ◽  
Influenza A ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Cell Responses

scholarly journals Systematic identification of immunodominant CD8+ T-cell responses to influenza A virus in HLA-A2 individuals

2011 ◽  
Vol 108 (22) ◽  
pp. 9178-9183 ◽  
Author(s):  
C. Wu ◽  
D. Zanker ◽  
S. Valkenburg ◽  
B. Tan ◽  
K. Kedzierska ◽  
...  
Keyword(s):  
T Cell ◽  
Influenza A Virus ◽  
Influenza A ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Cell Responses ◽  
Systematic Identification

scholarly journals Narrowing of Human Influenza A Virus-Specific T Cell Receptor α and β Repertoires with Increasing Age

2015 ◽  
Vol 89 (8) ◽  
pp. 4102-4116 ◽  
Author(s):  
Anna Gil ◽  
Maryam B. Yassai ◽  
Yuri N. Naumov ◽  
Liisa K. Selin
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Influenza A Virus ◽  
Influenza A ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Cell Receptor ◽  
Cross Reactivity ◽  
Older Individuals ◽  
Cell Responses

ABSTRACTAlterations in memory CD8 T cell responses may contribute to the high morbidity and mortality caused by seasonal influenza A virus (IAV) infections in older individuals. We questioned whether memory CD8 responses to this nonpersistent virus, to which recurrent exposure with new strains is common, changed over time with increasing age. Here, we show a direct correlation between increasing age and narrowing of the HLA-A2-restricted IAV Vα and Vβ T cell repertoires specific to M1 residues 58 to 66 (M158–66), which simultaneously lead to oligoclonal expansions, including the usage of a single identical VA12-JA29 clonotype in all eight older donors. The Vα repertoire of older individuals also had longer CDR3 regions with increased usage of G/A runs, whose molecular flexibility may enhance T cell receptor (TCR) promiscuity. Collectively, these results suggest that CD8 memory T cell responses to nonpersistent viruses like IAV in humans are dynamic, and with aging there is a reduced diversity but a preferential retention of T cell repertoires with features of enhanced cross-reactivity.IMPORTANCEWith increasing age, the immune system undergoes drastic changes, and older individuals have declined resistance to infections. Vaccinations become less effective, and infection with influenza A virus in older individuals is associated with higher morbidity and mortality. Here, we questioned whether T cell responses directed against the highly conserved HLA-A2-restricted M158–66peptide of IAV evolves with increasing age. Specifically, we postulated that CD8 T cell repertoires narrow with recurrent exposure and may thus be less efficient in response to new infections with new strains of IAV. Detailed analyses of the VA and VB TCR repertoires simultaneously showed a direct correlation between increasing age and narrowing of the TCR repertoire. Features of the TCRs indicated potentially enhanced cross-reactivity in all older donors. In summary, T cell repertoire analysis in older individuals may be useful as one of the predictors of protection after vaccination.

scholarly journals Overlapping Peptides Elicit Distinct CD8+ T Cell Responses following Influenza A Virus Infection

2020 ◽  
Vol 205 (7) ◽  
pp. 1731-1742
Author(s):  
Lisa M. Assmus ◽  
Jing Guan ◽  
Ting Wu ◽  
Carine Farenc ◽  
Xavier Y. X. Sng ◽  
...  
Keyword(s):  
T Cell ◽  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Cell Responses ◽  
Influenza A Virus Infection
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