Recent Advances in Soil Response Modeling for Well Conductor Fatigue Analysis and Development of New Approaches

2015 ◽  
Author(s):  
Arash Zakeri ◽  
Ed Clukey ◽  
Buba Kebadze ◽  
Philippe Jeanjean ◽  
Dan Walker ◽  
...  
Keyword(s):  
Fatigue Analysis ◽  
Soil Response ◽  
New Approaches ◽  
Recent Advances ◽  
Response Modeling

Assessing the Benefit of Innovations in ATC

1998 ◽  
Vol 51 (3) ◽  
pp. 312-320
Author(s):  
S. Ratcliffe
Keyword(s):  
Free Flight ◽  
New Approaches ◽  
Quantitative Studies ◽  
Traffic Capacity ◽  
Recent Advances ◽  
The Subject

Recent advances in technology have encouraged proposals for new approaches to ATC in Europe and elsewhere. Two such proposals, both rather loosely framed, are for ‘free flight’ or for ‘seamless contracts’; otherwise ‘tubes of flight’. These concepts, and variations on them, aim to increase the traffic capacity of the airspace. They have been the subject of numerous published papers. Given the declared objects of these systems, it is surprising that, nearly without exception, these papers discuss the proposals only in qualitative terms. The present paper discusses idealised versions of these systems on the basis of quantitative studies. It is concluded that the ‘seamless contract’ is very probably unworkable in Europe. ‘free flight’ is workable in principle, but there is a need for investigation of possible mechanisms by which last-minute problems may be resolved.

Recent Advances in Foraging Theory for Herbivores

2002 ◽  
Vol 2002 ◽  
pp. 235-236
Author(s):  
N.T. Hobbs
Keyword(s):  
Foraging Theory ◽  
Scientific Understanding ◽  
Mammalian Herbivores ◽  
New Approaches ◽  
Recent Advances

My remarks explore the role of theory in making progress in science generally and particularly in ecology. I discuss what theory is (and isn’t). I argue that theory is a fundamentally important part of doing science efficiently, and I discuss some exciting new approaches for combining theory, data, and statistics to enhance scientific understanding. I illustrate these approaches using examples from work on foraging by mammalian herbivores.

Immunotherapy for Brain Tumors

2017 ◽  
Vol 35 (21) ◽  
pp. 2450-2456 ◽  
Author(s):  
John H. Sampson ◽  
Marcela V. Maus ◽  
Carl H. June
Keyword(s):  
Brain Tumor ◽  
Tumor Microenvironment ◽  
Brain Tumors ◽  
Imaging Technologies ◽  
Cellular Therapies ◽  
New Approaches ◽  
Recent Advances ◽  
Medical Need

Glioblastoma (GBM) is the most lethal form of brain tumor and remains a large, unmet medical need. This review focuses on recent advances in the neurosciences that converge with the broader field of immuno-oncology. Recent findings in neuroanatomy provide a basis for new approaches of cellular therapies for tumors that involve the CNS. The ultimate success of immunotherapy in the CNS will require improved imaging technologies and methods for analysis of the tumor microenvironment in patients with GBM. It is likely that combinatorial approaches with targeted immunotherapies will be required to exploit the vulnerabilities of GBM and other brain tumors.

Platelets: Testing, Dosing and the Storage Lesion—Recent Advances

Hematology ◽  
2006 ◽  
Vol 2006 (1) ◽  
pp. 492-496 ◽  
Author(s):  
Richard M. Kaufman
Keyword(s):  
Ex Vivo ◽  
Storage Lesion ◽  
New Approaches ◽  
Platelet Storage Lesion ◽  
Platelet Storage ◽  
Recent Advances ◽  
The Future ◽  
Limited Supply ◽  
And Function ◽  
Platelet Transfusions

Abstract The demand for platelet transfusions continues to grow. Several complementary approaches that may help meet this demand in the future are reviewed. First, platelet bacterial testing is beginning to allow the extension of platelet storage beyond 5 days. Studies are also underway aimed at better preserving viability and function during ex vivo platelet storage: additive solutions and other approaches are being developed to try to negate the “platelet storage lesion.” Finally, new approaches to dosing platelets may help extend the limited supply.

scholarly journals Development of novel apparatus to obtain soil resistance–displacement relationship for well conductor fatigue analysis

2017 ◽  
Vol 54 (10) ◽  
pp. 1435-1446 ◽  
Author(s):  
Arash Zakeri ◽  
Hendrik Sturm ◽  
Rune Dyvik ◽  
Philippe Jeanjean
Keyword(s):  
Cyclic Loading ◽  
Interaction Mechanism ◽  
Physical Modelling ◽  
Fatigue Analysis ◽  
Test Results ◽  
Major Step ◽  
Soil Response ◽  
Geotechnical Centrifuge ◽  
Field Samples ◽  
Stress Changes

An important aspect of deepwater well integrity is development of accurate conductor fatigue analysis due to cyclic loading during drilling operations. Fatigue damage in a structure occurs from stress changes in response to cyclic loading. In practice, the lateral cyclic soil response is typically modelled using Winkler lateral load–displacement (p–y) springs. However, recently developed soil models for conductor fatigue analysis are based on physical modelling in a geotechnical centrifuge. Notwithstanding the advantages of centrifuge modelling for investigating the conductor–soil interaction mechanism, development of simple laboratory tools to obtain p–y data directly from intact soil samples obtained from the field can also be very beneficial. This paper describes the development of a novel apparatus to obtain p–y and soil damping relationships from field samples specifically tailored for well conductor fatigue analysis. In addition, it compares test results obtained using reconstituted kaolin clay and intact natural Onsøy clay with centrifuge test results; ultimately demonstrating a satisfactory agreement between the two techniques. The results are highly encouraging and are believed to present a major step forward in deepwater well conductor fatigue analysis. The findings may also be beneficial to the offshore renewable energy sector.

Recent Advances in Covalent Organic Frameworks for Cancer Diagnosis and Therapy

2021 ◽  
Author(s):  
Ahmad Reza Bagheri ◽  
Chengjun Li ◽  
Xiaoli Zhang ◽  
Xiaoxia Zhou ◽  
Nahal Aramesh ◽  
...  
Keyword(s):  
Cancer Diagnosis ◽  
Covalent Organic Frameworks ◽  
Design Development ◽  
Diagnosis And Therapy ◽  
New Approaches ◽  
Recent Advances ◽  
Number Of Patients ◽  
Different Types ◽  
Cancer Diagnosis And Therapy

In recent years, the number of patients diagnosed with cancer has been soaring. Therefore, the design, development, and implementation of new approaches for the diagnosis and therapy of different types...

Recent progress in mild Csp3–H bond dehydrogenative or (mono-) oxidative functionalization

2017 ◽  
Vol 15 (6) ◽  
pp. 1294-1312 ◽  
Author(s):  
Andrea Gini ◽  
Tobias Brandhofer ◽  
Olga García Mancheño
Keyword(s):  
Recent Progress ◽  
Bond Functionalization ◽  
Oxidative Functionalization ◽  
New Approaches ◽  
Recent Advances

This review summarizes recent advances in mild and green dehydrogenative and mono-oxidative Csp3–H bond functionalization reactions, considering both new approaches and the re-elaboration of known methodologies.

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