scholarly journals Effects of an inhibitor of 3beta-hydroxysteroid dehydrogenase on glucose, lipid metabolism and adipose tissue in a patient with type 2 diabetes, complicated with Cushing’s syndrome

2013 ◽  
Author(s):  
Yanai
Keyword(s):  
Type 2 Diabetes ◽  
Adipose Tissue ◽  
Lipid Metabolism ◽  
Cushing’S Syndrome ◽  
Hydroxysteroid Dehydrogenase ◽  
Cushing's Syndrome

scholarly journals Rapid control of ectopic Cushing’s syndrome during the COVID-19 pandemic in a patient with chronic hypokalaemia

2021 ◽  
Vol 2021 ◽  
Author(s):  
Ziadoon Faisal ◽  
Miguel Debono
Keyword(s):  
Type 2 Diabetes ◽  
Case Report ◽  
Cushing’S Syndrome ◽  
Cushing's Syndrome ◽  
Alternative Methods ◽  
Ectopic Acth Syndrome ◽  
High Dose ◽  
List Type ◽  
Ectopic Acth

Summary In this case report, we describe the management of a patient who was admitted with an ectopic ACTH syndrome during the COVID pandemic with new-onset type 2 diabetes, neutrophilia and unexplained hypokalaemia. These three findings when combined should alert physicians to the potential presence of Cushing’s syndrome (CS). On admission, a quick diagnosis of CS was made based on clinical and biochemical features and the patient was treated urgently using high dose oral metyrapone thus allowing delays in surgery and rapidly improving the patient’s clinical condition. This resulted in the treatment of hyperglycaemia, hypokalaemia and hypertension reducing cardiovascular risk and likely risk for infection. Observing COVID-19 pandemic international guidelines to treat patients with CS has shown to be effective and offers endocrinologists an option to manage these patients adequately in difficult times. Learning points This case report highlights the importance of having a low threshold for suspicion and investigation for Cushing’s syndrome in a patient with neutrophilia and hypokalaemia, recently diagnosed with type 2 diabetes especially in someone with catabolic features of the disease irrespective of losing weight. It also supports the use of alternative methods of approaching the diagnosis and treatment of Cushing’s syndrome during a pandemic as indicated by international protocols designed specifically for managing this condition during Covid-19.

scholarly journals The human type 2 diabetes-specific visceral adipose tissue proteome and transcriptome in obesity

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Nicholas J. Carruthers ◽  
Clarissa Strieder-Barboza ◽  
Joseph A. Caruso ◽  
Carmen G. Flesher ◽  
Nicki A. Baker ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Adipose Tissue ◽  
Fatty Acid ◽  
Lipid Metabolism ◽  
Visceral Adipose Tissue ◽  
Sequencing Analysis ◽  
Complement Factor ◽  
Endothelial Protein C Receptor ◽  
Visceral Adipose

AbstractDysfunctional visceral adipose tissue (VAT) in obesity is associated with type 2 diabetes (DM) but underlying mechanisms remain unclear. Our objective in this discovery analysis was to identify genes and proteins regulated by DM to elucidate aberrant cellular metabolic and signaling mediators. We performed label-free proteomics and RNA-sequencing analysis of VAT from female bariatric surgery subjects with DM and without DM (NDM). We quantified 1965 protein groups, 23 proteins, and 372 genes that were differently abundant in DM vs. NDM VAT. Proteins downregulated in DM were related to fatty acid synthesis and mitochondrial function (fatty acid synthase, FASN; dihydrolipoyl dehydrogenase, mitochondrial, E3 component, DLD; succinate dehydrogenase-α, SDHA) while proteins upregulated in DM were associated with innate immunity and transcriptional regulation (vitronectin, VTN; endothelial protein C receptor, EPCR; signal transducer and activator of transcription 5B, STAT5B). Transcriptome indicated defects in innate inflammation, lipid metabolism, and extracellular matrix (ECM) function, and components of complement classical and alternative cascades. The VAT proteome and transcriptome shared 13 biological processes impacted by DM, related to complement activation, cell proliferation and migration, ECM organization, lipid metabolism, and gluconeogenesis. Our data revealed a marked effect of DM in downregulating FASN. We also demonstrate enrichment of complement factor B (CFB), coagulation factor XIII A chain (F13A1), thrombospondin 1 (THBS1), and integrins at mRNA and protein levels, albeit with lower q-values and lack of Western blot or PCR confirmation. Our findings suggest putative mechanisms of VAT dysfunction in DM.

scholarly journals Screening of Cushing's Syndrome in Outpatients with Type 2 Diabetes: Results of a Prospective Multicentric Study in Italy

2012 ◽  
Vol 97 (10) ◽  
pp. 3467-3475 ◽  
Author(s):  
Massimo Terzolo ◽  
Giuseppe Reimondo ◽  
Iacopo Chiodini ◽  
Roberto Castello ◽  
Roberta Giordano ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cushing’S Syndrome ◽  
Cushing's Syndrome ◽  
Multicentric Study

scholarly journals FKBP5 expression in human adipose tissue: potential role in glucose and lipid metabolism, adipogenesis and type 2 diabetes

Endocrine ◽  
2018 ◽  
Vol 62 (1) ◽  
pp. 116-128 ◽  
Author(s):  
Cherno O. Sidibeh ◽  
Maria J. Pereira ◽  
Xesus M. Abalo ◽  
Gretha J. Boersma ◽  
Stanko Skrtic ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Adipose Tissue ◽  
Lipid Metabolism ◽  
Potential Role ◽  
Human Adipose Tissue ◽  
Glucose And Lipid Metabolism

Type 2 diabetes identified in pregnancy secondary to Cushing's syndrome

2011 ◽  
Vol 31 (6) ◽  
pp. 541-541 ◽  
Author(s):  
R. Schiemer ◽  
M. Latibeaudiere ◽  
C. Close ◽  
R. Fox
Keyword(s):  
Type 2 Diabetes ◽  
Cushing’S Syndrome ◽  
Cushing's Syndrome ◽  
In Pregnancy
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