scholarly journals Screening of Cushing's Syndrome in Outpatients with Type 2 Diabetes: Results of a Prospective Multicentric Study in Italy

2012 ◽  
Vol 97 (10) ◽  
pp. 3467-3475 ◽  
Author(s):  
Massimo Terzolo ◽  
Giuseppe Reimondo ◽  
Iacopo Chiodini ◽  
Roberto Castello ◽  
Roberta Giordano ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cushing’S Syndrome ◽  
Cushing's Syndrome ◽  
Multicentric Study

scholarly journals Rapid control of ectopic Cushing’s syndrome during the COVID-19 pandemic in a patient with chronic hypokalaemia

2021 ◽  
Vol 2021 ◽  
Author(s):  
Ziadoon Faisal ◽  
Miguel Debono
Keyword(s):  
Type 2 Diabetes ◽  
Case Report ◽  
Cushing’S Syndrome ◽  
Cushing's Syndrome ◽  
Alternative Methods ◽  
Ectopic Acth Syndrome ◽  
High Dose ◽  
List Type ◽  
Ectopic Acth

Summary In this case report, we describe the management of a patient who was admitted with an ectopic ACTH syndrome during the COVID pandemic with new-onset type 2 diabetes, neutrophilia and unexplained hypokalaemia. These three findings when combined should alert physicians to the potential presence of Cushing’s syndrome (CS). On admission, a quick diagnosis of CS was made based on clinical and biochemical features and the patient was treated urgently using high dose oral metyrapone thus allowing delays in surgery and rapidly improving the patient’s clinical condition. This resulted in the treatment of hyperglycaemia, hypokalaemia and hypertension reducing cardiovascular risk and likely risk for infection. Observing COVID-19 pandemic international guidelines to treat patients with CS has shown to be effective and offers endocrinologists an option to manage these patients adequately in difficult times. Learning points This case report highlights the importance of having a low threshold for suspicion and investigation for Cushing’s syndrome in a patient with neutrophilia and hypokalaemia, recently diagnosed with type 2 diabetes especially in someone with catabolic features of the disease irrespective of losing weight. It also supports the use of alternative methods of approaching the diagnosis and treatment of Cushing’s syndrome during a pandemic as indicated by international protocols designed specifically for managing this condition during Covid-19.

Type 2 diabetes identified in pregnancy secondary to Cushing's syndrome

2011 ◽  
Vol 31 (6) ◽  
pp. 541-541 ◽  
Author(s):  
R. Schiemer ◽  
M. Latibeaudiere ◽  
C. Close ◽  
R. Fox
Keyword(s):  
Type 2 Diabetes ◽  
Cushing’S Syndrome ◽  
Cushing's Syndrome ◽  
In Pregnancy

scholarly journals Is It Relevant to Screen Subclinical Cushing’s Syndrome in Patients With Type 2 Diabetes Mellitus?

2017 ◽  
Vol 7 (6) ◽  
pp. 178-184
Author(s):  
Manel Jemel Hadiji ◽  
Imen Ksira ◽  
Emna Haouat ◽  
Henda Kammoun Jamoussi ◽  
Leila Ben Salem Hachmi
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cushing’S Syndrome ◽  
Cushing's Syndrome ◽  
Subclinical Cushing’S Syndrome

scholarly journals Increased diagnostic probability of subclinical cushing’s syndrome in a population sample of overweight adult patients with type 2 diabetes mellitus

2007 ◽  
Vol 51 (7) ◽  
pp. 1118-1127 ◽  
Author(s):  
Maria Silvia S. Caetano ◽  
Regina do Carmo Silva ◽  
Claudio E. Kater
Keyword(s):  
Type 2 Diabetes ◽  
Cushing’S Syndrome ◽  
Population Sample ◽  
Serum Cortisol ◽  
Final Diagnosis ◽  
Cushing's Syndrome ◽  
False Positive Test ◽  
Populations At Risk ◽  
Overweight Adult

Endogenous Cushing’s Syndrome (CS) is unusual. Patients with subclinical CS (SCS) present altered cortisol dynamics without obvious manifestations. CS occurs in 2-3% of obese poorly controlled diabetics. We studied 103 overweight adult outpatients with type 2 diabetes to examine for cortisol abnormalities and SCS. All collected salivary cortisol at 23:00 h and salivary and serum cortisol after a 1 mg dexamethasone suppression test (DST). Patients whose results were in the upper quintile for each test (253 ng/dL, 47 ng/dL, and 1.8 mg/dL, respectively for the 23:00 h and post-DST saliva and serum cortisol) were re-investigated. Average values from the upper quintile group were 2.5-fold higher than in the remaining patients. After a confirmatory 2 mg x 2 day DST the investigation for CS was ended for 61 patients with all normal tests and 33 with only one (false) positive test. All 8 patients who had two abnormal tests had subsequent normal 24h-urinary cortisol, and 3 of them were likely to have SCS (abnormal cortisol tests and positive imaging). However, a final diagnosis could not to be confirmed by surgery or pathology. Although not confirmatory, the results of this study suggest that the prevalence of SCS is considerably higher in populations at risk than in the general population.

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