Design and Synthesis of Photoresponsive Crown Ethers via Olefin Metathesis

Heterocycles ◽  
1988 ◽  
Vol 27 (10) ◽  
pp. 2293 ◽  
Author(s):  
Ken Kanematsu ◽  
Kenji Hayakawa ◽  
Ryo Naito
Keyword(s):  
Crown Ethers ◽  
Olefin Metathesis ◽  
Design And Synthesis

Design and synthesis of constrained epothilone analogs: The efficient synthesis of eleven-membered rings by olefin metathesis

Tetrahedron ◽  
1999 ◽  
Vol 55 (27) ◽  
pp. 8199-8214 ◽  
Author(s):  
Jeffrey D. Winkler ◽  
Joanne M. Holland ◽  
Jiri Kasparec ◽  
Paul H. Axelsen
Keyword(s):  
Olefin Metathesis ◽  
Efficient Synthesis ◽  
Design And Synthesis

ChemInform Abstract: Design and Synthesis of Constrained Epothilone Analogues: The Efficient Synthesis of Eleven-Membered Rings by Olefin Metathesis.

ChemInform ◽  
2010 ◽  
Vol 30 (39) ◽  
pp. no-no
Author(s):  
Jeffrey D. Winkler ◽  
Joanne M. Holland ◽  
Jiri Kasparec ◽  
Paul H. Axelsen
Keyword(s):  
Olefin Metathesis ◽  
Efficient Synthesis ◽  
Design And Synthesis

ChemInform Abstract: Olefin Metathesis in the Design and Synthesis of a Globally Constrained Grb2 SH2 Domain Inhibitor.

ChemInform ◽  
2010 ◽  
Vol 32 (37) ◽  
pp. no-no
Author(s):  
Yang Gao ◽  
Chang-Qing Wei ◽  
Terrence R. Burke Jr.
Keyword(s):  
Olefin Metathesis ◽  
Sh2 Domain ◽  
Design And Synthesis

Olefin Metathesis in the Design and Synthesis of a Globally Constrained Grb2 SH2 Domain Inhibitor

2001 ◽  
Vol 3 (11) ◽  
pp. 1617-1620 ◽  
Author(s):  
Yang Gao ◽  
Chang-Qing Wei ◽  
Terrence R. Burke
Keyword(s):  
Olefin Metathesis ◽  
Sh2 Domain ◽  
Design And Synthesis

Application of Phenylphosphate Mimetics to the Design and Synthesis of Olefin Metathesis-Derived Grb2 SH2 Domain-Binding Macrocycles

2006 ◽  
pp. 180-181
Author(s):  
Sang-Uk Kang ◽  
Zhen-Dan Shi1 ◽  
Rajeshri Kariki1 ◽  
Jason Phan ◽  
Karen M. Worthy ◽  
...  
Keyword(s):  
Olefin Metathesis ◽  
Sh2 Domain ◽  
Design And Synthesis

Prostatic Acid Phosphatase (PAP) Differentiated Ultracytochemically from Lysosomal Acid Phosphate in the Rat with a PAP/Specific Substrate, Phosphorylcholine

1975 ◽  
Vol 33 ◽  
pp. 450-451
Author(s):  
W. Allen Shannon ◽  
José A. Serrano ◽  
Hannah L. Wasserkrug ◽  
Anna A. Serrano ◽  
Arnold M. Seligman
Keyword(s):  
Acid Phosphatase ◽  
Phosphate Buffer ◽  
Prostatic Carcinoma ◽  
Prostatic Acid Phosphatase ◽  
Chemotherapeutic Agents ◽  
Specific Substrate ◽  
Acid Phosphate ◽  
Lysosomal Acid ◽  
Design And Synthesis ◽  
New Chemotherapeutic Agents

During the design and synthesis of new chemotherapeutic agents for prostatic carcinoma based on phosphorylated agents which might be enzyme-activated to cytotoxicity, phosphorylcholine, [(CH3)3+NCH2CH2OPO3Ca]Cl-, has been indicated to be a very specific substrate for prostatic acid phosphatase (PAP). This phenomenon has led to the development of specific histochemical and ultracytochemical methods for PAP using modifications of the Gomori lead method for acid phosphatase. Comparative histochemical results in prostate and kidney of the rat have been published earlier with phosphorylcholine (PC) and β-glycerophosphate (βGP). We now report the ultracytochemical results.Minced tissues were fixed in 3% glutaraldehyde-0.1 M phosphate buffered (pH 7.4) for 1.5 hr and rinsed overnight in several changes of 0.05 M phosphate buffer (pH 7.0) containing 7.5% sucrose. Tissues were incubated 30 min to 2 hr in Gomori acid phosphatase medium (2) containing 0.1 M substrate, either PC or βGP.

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