scholarly journals DESIGN AND SYNTHESIS OF THE NEXT GENERATION OF CROWN ETHERS FOR WASTE SEPARATIONS: AN INTER-LABORATORY COMPREHENSIVE PROPOSAL

2000 ◽  
Author(s):  
Bruce A Moyer
Keyword(s):  
Crown Ethers ◽  
Next Generation ◽  
Design And Synthesis

Design and Synthesis of Photoresponsive Crown Ethers via Olefin Metathesis

Heterocycles ◽  
1988 ◽  
Vol 27 (10) ◽  
pp. 2293 ◽  
Author(s):  
Ken Kanematsu ◽  
Kenji Hayakawa ◽  
Ryo Naito
Keyword(s):  
Crown Ethers ◽  
Olefin Metathesis ◽  
Design And Synthesis

Molecular hybridization design and synthesis of novel spirooxindole-based MDM2 inhibitors endowed with BCL2 signaling attenuation; a step towards the next generation p53 activators

2021 ◽  
pp. 105427
Author(s):  
Gehad Lotfy ◽  
Yasmine M. Abdel Aziz ◽  
Mohamed M. Said ◽  
El Sayed H. El Ashry ◽  
El Sayed H. El Tamany ◽  
...  
Keyword(s):  
Molecular Hybridization ◽  
Next Generation ◽  
Design And Synthesis

ChemInform Abstract: The Next Generation of MMP Inhibitors: Design and Synthesis

ChemInform ◽  
2010 ◽  
Vol 30 (51) ◽  
pp. no-no
Author(s):  
Biswanath De ◽  
Michael G. Natchus ◽  
Menyan Cheng ◽  
Stanislaw Pikul ◽  
Neil G. Almstead ◽  
...  
Keyword(s):  
Next Generation ◽  
Mmp Inhibitors ◽  
Design And Synthesis

The Next Generation of MMP Inhibitors: Design and Synthesis

1999 ◽  
Vol 878 (1 INHIBITION OF) ◽  
pp. 40-60 ◽  
Author(s):  
BISWANATH DE ◽  
MICHAEL G. NATCHUS ◽  
MENYAN CHENG ◽  
STANISLAW PIKUL ◽  
NEIL G. ALMSTEAD ◽  
...  
Keyword(s):  
Next Generation ◽  
Mmp Inhibitors ◽  
Design And Synthesis

Prostatic Acid Phosphatase (PAP) Differentiated Ultracytochemically from Lysosomal Acid Phosphate in the Rat with a PAP/Specific Substrate, Phosphorylcholine

1975 ◽  
Vol 33 ◽  
pp. 450-451
Author(s):  
W. Allen Shannon ◽  
José A. Serrano ◽  
Hannah L. Wasserkrug ◽  
Anna A. Serrano ◽  
Arnold M. Seligman
Keyword(s):  
Acid Phosphatase ◽  
Phosphate Buffer ◽  
Prostatic Carcinoma ◽  
Prostatic Acid Phosphatase ◽  
Chemotherapeutic Agents ◽  
Specific Substrate ◽  
Acid Phosphate ◽  
Lysosomal Acid ◽  
Design And Synthesis ◽  
New Chemotherapeutic Agents

During the design and synthesis of new chemotherapeutic agents for prostatic carcinoma based on phosphorylated agents which might be enzyme-activated to cytotoxicity, phosphorylcholine, [(CH3)3+NCH2CH2OPO3Ca]Cl-, has been indicated to be a very specific substrate for prostatic acid phosphatase (PAP). This phenomenon has led to the development of specific histochemical and ultracytochemical methods for PAP using modifications of the Gomori lead method for acid phosphatase. Comparative histochemical results in prostate and kidney of the rat have been published earlier with phosphorylcholine (PC) and β-glycerophosphate (βGP). We now report the ultracytochemical results.Minced tissues were fixed in 3% glutaraldehyde-0.1 M phosphate buffered (pH 7.4) for 1.5 hr and rinsed overnight in several changes of 0.05 M phosphate buffer (pH 7.0) containing 7.5% sucrose. Tissues were incubated 30 min to 2 hr in Gomori acid phosphatase medium (2) containing 0.1 M substrate, either PC or βGP.

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