Immunomodulatory Activity and Th1/Th2 Cytokine Response of Ocimum sanctum in Myelosuppressed Swiss Albino Mice

2011 ◽  
Vol 6 (1) ◽  
pp. 23-31 ◽  
Author(s):  
R. Hemalatha ◽  
K. Narendra Babu ◽  
M. Karthik ◽  
R. Ramesh ◽  
B. Dinesh Kumar ◽  
...  
Keyword(s):  
Cytokine Response ◽  
Ocimum Sanctum ◽  
Immunomodulatory Activity ◽  
Swiss Albino Mice ◽  
Th2 Cytokine ◽  
Albino Mice

scholarly journals Immunomodulatory activity of an aqueous extract of Polygonum minus Huds on Swiss albino mice using carbon clearance assay

2014 ◽  
Vol 4 (5) ◽  
pp. 398-400 ◽  
Author(s):  
Annie George ◽  
Sasikala Chinnappan ◽  
Yogendra Choudhary ◽  
Praveen Bommu ◽  
Murthy Sridhar
Keyword(s):  
Aqueous Extract ◽  
Immunomodulatory Activity ◽  
Swiss Albino Mice ◽  
Carbon Clearance ◽  
Polygonum Minus ◽  
Albino Mice

scholarly journals Neuroprotective Activity of Evolvulus alsinoides & Centella asiatica Ethanolic Extracts in Scopolamine-Induced Amnesia in Swiss Albino Mice

2019 ◽  
Vol 7 (7) ◽  
pp. 1059-1066 ◽  
Author(s):  
Mukesh Kumar Yadav ◽  
Santosh Kumar Singh ◽  
Manish Singh ◽  
Shashank Shekhar Mishra ◽  
Anurag Kumar Singh ◽  
...  
Keyword(s):  
Neuroprotective Effect ◽  
Centella Asiatica ◽  
Neuroprotective Activity ◽  
Immunomodulatory Activity ◽  
Histopathological Analysis ◽  
Nootropic Activity ◽  
Swiss Albino Mice ◽  
Evolvulus Alsinoides ◽  
Ethanolic Extracts ◽  
Albino Mice

AIM: To carry out the comparative nootropic, neuroprotective potentials of two medicinal plant species. MATERIAL AND METHODS: For neuroprotective activity; behavior models (elevated plus maze & morris water maze), in vivo antioxidant (superoxide dismutase, catalase, lipid peroxidation & reduced glutathione), inflammatory markers (IL-1β, IL-6 & TNF-α) and acetylcholine esterase (AChE) assessment procedures followed at different dosages i.e. 250 & 500 mg/kg of Evolvulus alsinoides and Centella asiatica ethanolic extracts. At the end of the study, it was performed histopathological analysis of the following organs: brain, heart, liver, and kidney. RESULTS: In oral administration of different doses of ethanolic extracts of both medicinal plants i.e. Sco + EEA 250 = 2.49 ± 0.29 , Sco + EEA 500 = 2.67 ± 0.36, Sco + ECA 250 = 2.33 ± 0.17, Sco + ECA 500 = 2.77 ± 0.21, Sco + EEA + ECA 250 = 2.61 ± 0.32 and Sco + EEA + ECA 500 = 2.79 ± 0.16 U/mg of protein respectively against the scopolamine induced group Sco (control) = 5.51 ± 0.35 U/mg of protein extracts shows neuroprotective and nootropic activity with reducing AChE level in the brain homogenate of swiss albino mice. CONCLUSION: Since the E. alsinoides & C. asiatica are already used in traditional Indian medicine as the neuroprotective agent and also found promising effects over inflammatory diseases, wound healing, and immunomodulatory activity. The neuroprotective effect of both plants extracts attributed to inhibition of AChE activity and improve the spatial memory formation.

Evaluation of immunomodulatory activity of ethyl acetate extract of Leucas aspera in Swiss albino mice

2014 ◽  
Vol 8 (2) ◽  
pp. 84 ◽  
Author(s):  
BibinBaby Augustine ◽  
Suvakanta Dash ◽  
Mangala Lahkar ◽  
VenketeswaraRao Amara ◽  
PavanKumar Samudrala ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Ethyl Acetate Extract ◽  
Immunomodulatory Activity ◽  
Swiss Albino Mice ◽  
Leucas Aspera ◽  
Albino Mice

scholarly journals SODIUM FLUORIDE-INDUCED OXIDATIVE STRESS AND HISTOLOGICAL CHANGES IN LIVER OF SWISS ALBINO MICE AND AMELIORATION BY OCIMUM SANCTUM LINN.

2018 ◽  
Vol 11 (9) ◽  
pp. 195 ◽  
Author(s):  
Bhagwendra Prakash ◽  
Suresh Kumar Sabal ◽  
Rajbala Verma ◽  
John Pj ◽  
Inderpal Soni
Keyword(s):  
Oxidative Stress ◽  
Drinking Water ◽  
Body Weight ◽  
Leaf Extract ◽  
Mononuclear Cells ◽  
Tap Water ◽  
Ocimum Sanctum ◽  
High Dose ◽  
Swiss Albino Mice ◽  
Albino Mice

Objective: The present study was designed to evaluate hepatotoxicity induced by sodium fluoride (NaF) in Swiss albino mice and amelioration by Ocimum sanctum Linn.Methods: Mice were divided into six groups, Group I received tap water, Group II received low dose of NaF (8 mg/L), Group III high dose of NaF (80 mg/L) in drinking water, Group IV tap water along with 250 mg/kg body weight/day leaf extract of O. sanctum Linn., Group V 8 mg/L NaF in drinking water and 250 mg/kg body weight leaf extract of O. sanctum Linn., and Group VI 80 mg/L NaF in drinking water along with leaf extract of O. sanctum Linn. 250 mg/kg body weight/day for 90 days. On the 91st day, the animals were autopsied and liver tissue samples were taken to assess histopathological changes and oxidative stress by estimating glutathione peroxidase, superoxide dismutase, and catalase.Results: A highly significant decrease in the activity of antioxidant enzymes occurred with the high dose (Group III). Hepatic histopathological architecture exhibited deformities, namely, ballooning, hypertrophy, hepatocellular necrosis, infiltration of mononuclear cells, deformed central vein, sinusoidal dilation, and binucleated cells. Low-dose group (Group II) showed a significant decrease in antioxidant enzyme levels as compared to control group, and histological sections of liver showed dilated sinusoids, infiltration of mononuclear cells, ballooning, and hypertrophy of hepatocytes. Groups IV and V showed no pathological features. Group VI showed less damage to the liver as compared to Group III.Conclusion: The results revealed that the administration of leaf extract of O. sanctum Linn. elicited protection against NaF-induced hepatotoxicity and oxidative stress. It may, therefore, be inferred that fluoride caused hepatotoxicity in Swiss albino mice at the tested dose levels can be ameliorated by O. sanctum Linn.

Protective Effects of Prunus Avium Extract on 10 Ghz Induced Damages in the Spleen of Swiss Albino Mice

2011 ◽  
Vol 3 (8) ◽  
pp. 680-684 ◽  
Author(s):  
Faiza Rifat ◽  
◽  
Archana Sharma ◽  
Preeti Srivastava ◽  
Shikha Patni ◽  
...  
Keyword(s):  
Prunus Avium ◽  
Protective Effects ◽  
Swiss Albino Mice ◽  
Albino Mice

PROTECTIVE EFFECT OF ROSEMARY (ROSMARINUS OFFICINALIS L.) EXTRACT OVER THE GENOTOXICITY INDUCED BY CYCLOPHOSPHAMIDE IN SWISS ALBINO MICE

2016 ◽  
Vol 72 (9) ◽  
Author(s):  
Dr. Ayman Salah El-Seedy ◽  
Hany George Shalaby ◽  
Mohamed Ahmed El-Sehrigy ◽  
Madiha Mohiy El-Dein Ghoneim
Keyword(s):  
Protective Effect ◽  
Rosmarinus Officinalis ◽  
Swiss Albino Mice ◽  
Albino Mice ◽  
Rosmarinus Officinalis L

HAEMATO-BIOCHEMICAL AND IMMUNOLOGICAL CHANGES IN EXPERIMENTALLY INDUCED ACETAMIPRID TOXICITY IN SWISS ALBINO MICE

2016 ◽  
Vol 12 (1) ◽  
Author(s):  
D.T. Fefar ◽  
Ankita N. Brahmbhatt ◽  
B.P. Joshi ◽  
D.J. Ghodasara
Keyword(s):  
Dose Level ◽  
Significant Rise ◽  
High Dose ◽  
Cell Mediated Immunity ◽  
Swiss Albino Mice ◽  
Mean Values ◽  
Group Iii ◽  
Treatment Groups ◽  
Immunological Effects ◽  
Albino Mice

A study was conducted on 5 weeks old 64 (32 male and 32 female) Swiss albino mice to assess the haemato-biochemical and immunological effects of acetamiprid. All the male and female mice were randomly divided into eight different groups. The groups I (male) and II (female) served as controls whereas remaining groups served as treatment groups and were administered acetamiprid at the daily dose rate of 20, 10, 5 mg/kg body weight in males(Group III, V, VII) and females (Group IV, VI,VIII),respectively for 28 days. After 28 days treatment, blood samples were collected for hematological, biochemical as well as immunological analysis. There was significant decrease in haematological parameters like Hb, TEC, TLC, neutrophils and lymphocytes count in high dose groups and revealed potential adversity of acetamiprid at rates of 20 mg/kg/day on haematopoetic system of mice. A dose dependent significant rise in mean values of AST and ALT was observed in treatment groups, whereas there was significant decrease in total protein and albumin and increase in BUN in high and mid dose treated groups, irrespective of sex of mice. Dinitroflurobenzene (DNFB) test conducted to assess the cell mediated immunity revealed the toxic effect of acetamiprid on cell mediated immunity of mice at dose level of 10 mg/kg/day. The mice of high dose group revealed a significant decrease in HA titer and indicated the immunotoxic potential of acetamiprid at dose level of 20 mg/kg/day.

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