scholarly journals Palm Oil and Egusi Melon Oil Lower Serum and Liver Lipid Profile and Improve Antioxidant Activity in Rats Fed a High Fat Diet

2010 ◽  
Vol 8 (4) ◽  
pp. 154-158
Author(s):  
George O. Eidangbe ◽  
Godwin C. Ojieh ◽  
Blessing O. Idonije ◽  
Olarewaju M. Oluba
Keyword(s):  
Antioxidant Activity ◽  
Lipid Profile ◽  
Palm Oil ◽  
High Fat Diet ◽  
Liver Lipid ◽  
High Fat ◽  
Lower Serum

scholarly journals Olive Oil, Palm Oil, and Hybrid Palm Oil Distinctly Modulate Liver Transcriptome and Induce NAFLD in Mice Fed a High-Fat Diet

2018 ◽  
Vol 20 (1) ◽  
pp. 8 ◽  
Author(s):  
Rafael Sales ◽  
Priscylla Medeiros ◽  
Flavia Spreafico ◽  
Patrícia de Velasco ◽  
Fernanda Gonçalves ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Palm Oil ◽  
High Fat Diet ◽  
Protein Localization ◽  
Blood Lipid ◽  
Liver Fat ◽  
High Fat ◽  
Blood Lipid Profile ◽  
High Fat Diets ◽  
Fat Diets

Nonalcoholic fatty liver disease (NAFLD) is highly prevalent worldwide. The most severe form is nonalcoholic steatohepatitis (NASH). Among risk factors for the development of NAFLD is excessive lipid intake. Since palm (P) oil is the most consumed oil in the world, we aimed to investigate the effects of high-fat diets made with P oil, hybrid palm (HP) oil, or olive (O) oil in liver. Twenty-four male mice (C57Bl/6J) were fed a high-fat diet (41% fat) containing P, HP, or O oils for 8 weeks and compared to a control (C) group fed a chow diet. Adiposity was measured with computed tomography. Body, adipose tissue, and liver weights, as well as liver fat (Bligh–Dyer), blood lipid profile, glucose, and liver enzymes were measured. Liver histology (hematoxylin–eosin) and transcriptome (microarray-based) were performed. ANOVA tests with Newman–Keuls were used. Body weight was increased in the P group (p < 0.001) and body fat in the O group (C vs. O p ≤ 0.01, P vs. O p ≤ 0.05, HP vs. O p ≤ 0.05). All high-fat diets disturbed the blood lipid profile and glucose, with marked effects of HP on very low-density lipoprotein cholesterol (VLDL), triglycerides, and alkaline phosphatase (p ≤ 0.001). HP had the highest liver fat (42.76 ± 1.58), followed by P (33.94 ± 1.13). O had a fat amount comparable to C (16.46 ± 0.34, 14.71 ± 0.70, respectively). P and HP oils induced hepatocyte ballooning. Transcriptome alterations of the O group were related to amino acid metabolism and fatty acid (FA) metabolism, the P group to calcium ion homeostasis, and HP oil to protein localization. Both P and HP oils induced NASH in mice via disturbed hepatocyte transcription. This raises concerns about the content of these oils in several industrialized foods.

scholarly journals Antihyperlipidemic and Antioxidant Activities of Flavonoid-Rich Extract of Ziziphus lotus (L.) Lam. Fruits

2021 ◽  
Vol 11 (17) ◽  
pp. 7788
Author(s):  
Noureddine Bencheikh ◽  
Mohamed Bouhrim ◽  
Ilyass Alami Merrouni ◽  
Salima Boutahiri ◽  
Loubna Kharchoufa ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Lipid Profile ◽  
Aqueous Extract ◽  
High Fat Diet ◽  
Antioxidant Activities ◽  
Bioactive Molecules ◽  
High Fat ◽  
Antioxidant Power ◽  
Albino Mice ◽  
Β Carotene

Ziziphus lotus (L.) Lam. (Z. lotus) is a medicinal plant species that is widely distributed throughout the Mediterranean basin. Moroccans traditionally use it to treat many illnesses thanks to its beneficial medicinal properties. The purpose of this study is to assess the anti-hyperlipidemic and antioxidant activities of a flavonoid-rich aqueous extract of Z. lotus fruits (ZLF). The 2-2-diphenyl-1-picrylhydrazyl (DPPH) scavenging assay and the β-carotene bleaching test were used to determine the antioxidant activity of ZLF. The anti-hyperlipidemic effect of the aqueous extract of ZLF (200 and 400 mg/kg) was evaluated in albino mice exposed to the chronic high-fat diet, based on lipid profile, blood sugar, and changes in growth performance. The results showed that the aqueous extract of ZLF rich in flavonoids (2242.89 ± 25 µg QE (quercitin equivalent)/mg), and has a considerable antioxidant power against DPPH radicals (IC50 = 116 ± 0.02 µg/mL) and β-carotene oxidation. The aqueous extract of ZLF also showed a significant anti-hyperlipidemic effect by improving abnormal changes in lipid profile and blood glucose levels in albino mice exposed to a chronic high-fat diet. Our findings suggest that the anti-hyperlipidemic activities of ZLF aqueous extract are correlated with its flavonoid content and antioxidant activity. Therefore, the aqueous extract of ZLF could be an essential therapeutic candidate for hyperlipidemia patients, thanks to its richness in bioactive molecules.

scholarly journals Phenolic Content and Antioxidant, Antihyperlipidemic, and Antidiabetogenic Effects of Opuntia dillenii Seed Oil

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Mohamed Bouhrim ◽  
Nour Elhouda Daoudi ◽  
Hayat Ouassou ◽  
Amina Benoutman ◽  
El Hassania Loukili ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Lipid Profile ◽  
High Fat Diet ◽  
Total Phenolic Content ◽  
Phenolic Content ◽  
Total Phenolic ◽  
High Fat ◽  
Albino Mice ◽  
Dpph Scavenging ◽  
Opuntia Dillenii

Opuntia dillenii (Ker-Gawl.) Haw. is a medicinal plant that is widely used by the Moroccan population to treat many diseases, thanks to its richness in bioactive molecules. This study aims to evaluate the total phenolic content and antioxidant, antihyperlipidemic, and antidiabetogenic activities of O. dillenii seeds oil (ODSO), in vivo. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging assay and the Folin–Ciocalteu method were applied in this study to determine antioxidant activity and total phenolic content of ODSO, respectively. The antihyperlipidemic effect of the ODSO (2 ml/kg) was evaluated in the high-fat diet-fed albino mice, relying on lipid profile, blood glucose, and growth performance variations. Moreover, the preventive effect of ODSO was evaluated against alloxan monohydrate-induced diabetes in albino mice. ODSO had the highest total phenolic content (518.18 ± 14.36 mg EAC/kg) and DPPH scavenging activity (IC50 = 0.38 ± 0.08 mg/mL). Furthermore, ODSO showed a significant antidiabetogenic effect by reducing bodyweight loss, blood sugar level rise, and mortality rate caused by alloxan in albino mice. Then, ODSO has exhibited a significant antihyperlipidemic effect by improving the lipid profile disorder and glucose level rise in the blood, produced by the high-fat diet-fed albino mice. Results suggest that antidiabetogenic and antihyperlipidemic activities of ODSO correlate to the phenolic content and antioxidant activity of this oil. Hence, this plant could be a significant source of medically important critical compounds.

Abstract 037: Role of Pro-opiomelanocortin (POMC) Specific PTP1B in Differential Regulation of Blood Pressure, Liver Lipid Accumulation and Glucose Tolerance in Response to a High Fat Diet

Hypertension ◽  
2016 ◽  
Vol 68 (suppl_1) ◽  
Author(s):  
Nicola Aberdein ◽  
Jussara M do Carmo ◽  
Zhen Wang ◽  
Taolin Fang ◽  
Cecilia P de Lara ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Glucose Tolerance ◽  
Fat Mass ◽  
Lipid Accumulation ◽  
High Fat Diet ◽  
Acute Stress ◽  
Liver Lipid ◽  
Liver Weight ◽  
Metabolic Effects ◽  
High Fat

Obese subjects are often resistant to leptin’s metabolic effects although blood pressure (BP) and sympathetic nervous system responses appear to be preserved. Protein tyrosine phosphatase 1B (PTP1B), a negative regulator of leptin signaling, may play a role in promoting this selective leptin resistance and causing metabolic dysfunction in obesity. Our previous studies suggest that the chronic BP responses to leptin are mediated via activation of pro-opiomelanocortin (POMC) neurons. The goal of this study was to determine if PTP1B in POMC neurons differentially controls metabolic functions and BP in mice fed a high fat diet (HFD). Male mice with POMC specific PTP1B deletion (POMC/PTP1B -/- ) and littermate controls (PTP1B flox/flox ) were fed a HFD from 6 to 22 wks of age. Baseline BP after 16 weeks of a HFD (95±2 vs. 95±3 mmHg) and BP responses to acute stress (Δ32±0 vs. Δ32±6 mmHg), measured by telemetry, were not different in POMC/PTP1B -/- compared to control mice, respectively. Heart rate (HR) was not different in POMC/PTP1B -/- and control mice during acute stress (699±4 vs. 697±15 bpm, respectively). Total body weight (TBW) and fat mass were reduced at 20 weeks of age in POMC/PTP1B -/- compared to controls (36.7±0.1 vs. 42.0±1 g TBW and 12.7±0.4 vs. 16.1±1.0 g fat mass, respectively). Liver weight of POMC/PTP1B -/- mice was less than in controls, and this was evident even when liver weight was normalized as % of TBW (4.5±0.2 vs. 5.0±0.2 %). POMC/PTP1B -/- males had reduced liver lipid accumulation compared to controls as measured by EchoMRI (0.08±0.03 vs. 0.15±0.03 g/g liver weight). Glucose tolerance was also improved by 46% in POMC/PTP1B -/- compared to controls as measured by AUC, 25856±1683 vs. 47267±5616 mg/dLx120min, respectively. These findings indicate that PTP1B signaling in POMC neurons plays a crucial role in regulating liver lipid accumulation and glucose tolerance but does not appear to mediate changes in BP or BP responses to acute stress in mice fed a high HFD (supported by NHLBI-PO1HL51971 and NIGMS P20GM104357)

Anti-obesity action of gingerol: effect on lipid profile, insulin, leptin, amylase and lipase in male obese rats induced by a high-fat diet

2014 ◽  
Vol 94 (14) ◽  
pp. 2972-2977 ◽  
Author(s):  
Ganapathy Saravanan ◽  
Ponnusamy Ponmurugan ◽  
Machampalayam Arumugam Deepa ◽  
Balasubramanian Senthilkumar
Keyword(s):  
Lipid Profile ◽  
High Fat Diet ◽  
High Fat ◽  
Obese Rats

Lipid profile of mice fed a high-fat diet supplemented with a wax ester-rich marine oil

2014 ◽  
Vol 116 (12) ◽  
pp. 1718-1726 ◽  
Author(s):  
Alice Marie Pedersen ◽  
Wahida Salma ◽  
Anje Christina Höper ◽  
Terje Steinar Larsen ◽  
Ragnar Ludvig Olsen
Keyword(s):  
Lipid Profile ◽  
High Fat Diet ◽  
Wax Ester ◽  
High Fat ◽  
Marine Oil

Lipid profile lowering effect of SoyproTMfermented with lactic acid bacteria isolated from Kimchi in high-fat diet-induced obese rats

BioFactors ◽  
2008 ◽  
Vol 33 (1) ◽  
pp. 49-60 ◽  
Author(s):  
Na-Hyung Kim ◽  
Hyung-Min Kim ◽  
Hyo-Jin An ◽  
Jae-Young Um ◽  
Phil-Dong Moon ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Lactic Acid Bacteria ◽  
Lipid Profile ◽  
High Fat Diet ◽  
High Fat ◽  
Lowering Effect ◽  
Obese Rats
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