scholarly journals A Case of Recurrent Anaplastic Thyroid Cancer Treated by Lenvatinib after Successful Long-term Multimodal Therapy

2016 ◽  
Vol 77 (2) ◽  
pp. 291-295 ◽  
Author(s):  
Naoyoshi ONODA ◽  
Mao TOKUMOTO ◽  
Satoru NODA ◽  
Go OHIRA ◽  
Shinichiro KASHIWAGI ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Multimodal Therapy ◽  
Anaplastic Thyroid Cancer

scholarly journals Anaplastic Thyroid Cancer Presenting With Brain Metastasis: 17-year Progression Free Survival

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A882-A883
Author(s):  
Kathryn Kay Howard ◽  
Morta Lapkus ◽  
Natalie Luehmann ◽  
Sapna Nagar ◽  
Peter Czako
Keyword(s):  
Thyroid Cancer ◽  
Brain Lesion ◽  
Anaplastic Thyroid Cancer ◽  
Brain Lesions ◽  
Term Survival ◽  
Whole Brain ◽  
Long Term Survival ◽  
Whole Brain Radiation ◽  
Brain Radiation

Abstract Anaplastic Thyroid Cancer is the most aggressive thyroid cancer with a median survival of just five months. Long term survival has been reported in locally aggressive cases but has yet to be reported in metastatic disease. This is a report of a 34-year-old male who presented with symptoms of dizziness, confusion, intermittent headaches, and erratic behavior for two weeks found to have metastatic anaplastic thyroid cancer. CT of the head revealed a 1 cm ring enhancing lesion and he was taken to the operating room for a left parietal craniotomy with mass removal. Initial pathology suggested papillary thyroid origin. His neck exam revealed a palpable 3 cm mass in the right thyroid lobe and he subsequently underwent total thyroidectomy. Final pathology revealed anaplastic carcinoma identical to the brain lesion. Post-operatively, he underwent 15 cycles of whole brain radiation therapy. Two additional brain lesions were identified after thyroidectomy and a third was identified after whole brain radiation. He underwent stereotactic radiosurgery of these three lesions less than two months after thyroidectomy. The patient went on to receive modified mantle field irradiation to the neck, thyroid bed, and the upper mediastinum and chemotherapy with doxorubicin for 6-8 weeks and temozolomide for 2 years. Radioactive iodine treatment was not administered. The patient has currently survived 17 years and his persistent, but stable, brain lesions are being followed with serial imaging. He remains clinically and neurologically asymptomatic. This is the first case presenting with long-term survival in a patient with metastatic anaplastic thyroid carcinoma.

scholarly journals A rare case of anaplastic thyroid carcinoma in a young woman with prolonged survival

2013 ◽  
Vol 60 (4) ◽  
pp. 99-101
Author(s):  
Katarina Tausanovic ◽  
Vladan Zivaljevic ◽  
Ivan Paunovic ◽  
Aleksandar Diklic ◽  
Nevena Kalezic ◽  
...  
Keyword(s):  
Rare Case ◽  
Multimodal Therapy ◽  
Anaplastic Thyroid Cancer ◽  
The Elderly ◽  
Anaplastic Thyroid Carcinoma ◽  
Human Medicine ◽  
Term Survival ◽  
Average Survival ◽  
Aggressive Tumors

Anaplastic thyroid cancer (ATC) is one of the most aggressive tumors in human medicine. Despite the multimodal therapy, the average survival of patients is just several months. Fortunately, it is an extremely rare tumor. Most frequently, ATC occurs in the elderly, with the average age of the patients being almost 70 years. It is extremely rare that ATC occurs in people under the age of 40. We report a case of a 33 year old woman with ATC, with the diameter of the tumor being 8x7cm, confirmed by histopathology and imunohistochemistry. In January 2001, a total thyroidectomy was performed, and the tumor was completely resected. Postoperatively, the patient received radiation therapy. Ten years after the surgery, on regular check-ups, the patient is still living and there is no evidence of a recurrent tumor or metastases. This case is instructive for two reasons, as it shows that ATC can occur in younger people and that there is a possibility of long term survival.

scholarly journals Expression of PD-1 and PD-L1 in Anaplastic Thyroid Cancer Patients Treated With Multimodal Therapy: Results From a Retrospective Study

2017 ◽  
Vol 102 (6) ◽  
pp. 1943-1950 ◽  
Author(s):  
Ashish V. Chintakuntlawar ◽  
Kandelaria M. Rumilla ◽  
Carin Y. Smith ◽  
Sarah M. Jenkins ◽  
Robert L. Foote ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Retrospective Study ◽  
Cancer Patients ◽  
Multimodal Therapy ◽  
Anaplastic Thyroid Cancer

scholarly journals Outcomes of multimodal therapy in a large series of patients with anaplastic thyroid cancer

Cancer ◽  
2019 ◽  
Vol 126 (2) ◽  
pp. 444-452 ◽  
Author(s):  
Dan Fan ◽  
Jennifer Ma ◽  
Andrew C. Bell ◽  
Andries H. Groen ◽  
Kyrie S. Olsen ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Multimodal Therapy ◽  
Anaplastic Thyroid Cancer ◽  
Large Series

scholarly journals Anaplastic Thyroid Cancer with Uncommon Long-term Survival

2006 ◽  
Vol 69 (10) ◽  
pp. 489-491 ◽  
Author(s):  
Ai-Hung Liu ◽  
Li-Ying Juan ◽  
An-Hang Yang ◽  
Harn-Shen Chen ◽  
Hong-Da Lin
Keyword(s):  
Thyroid Cancer ◽  
Anaplastic Thyroid Cancer ◽  
Term Survival ◽  
Long Term Survival

scholarly journals MON-446 Anaplastic Thyroid Cancer Presenting with Brain Metastasis: 17-Year Progression Free Survival

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Kathryn Kay Howard ◽  
Morta Lapkus ◽  
Natalie Johnson ◽  
Sapna Nagar ◽  
Peter Czako
Keyword(s):  
Thyroid Cancer ◽  
Radioactive Iodine ◽  
Anaplastic Thyroid Cancer ◽  
Brain Lesions ◽  
Term Survival ◽  
Long Term Survival ◽  
Whole Brain Radiation ◽  
Iodine Treatment ◽  
Brain Radiation

Abstract Background: Anaplastic Thyroid Cancer is the most aggressive thyroid cancer with a median survival of just five months. Long term survival has been reported in locally aggressive cases, but has yet to be reported in metastatic disease. Case Information: A 34-year-old male presented with symptoms of dizziness, confusion, intermittent headaches, and erratic behavior for two weeks. CT of the head revealed a 1 cm ring enhancing lesion in the left parietal lobe with surrounding vasogenic edema. He was taken to the operating room for a left parietal craniotomy and a vascular, solid mass was removed. Initial pathology suggested papillary thyroid origin due to positive staining for thyroid transcription factor (TTF) and thyroglobulin (Tg). On exam, he had a palpable 3 cm mass in the right thyroid lobe with no associated adenopathy. He underwent thyroidectomy to optimize post-operative radioactive iodine treatment. Intraoperative frozen section revealed anaplastic thyroid cancer and final pathology revealed anaplastic carcinoma identical to the brain lesion. The tumor pathology showed extension through the thyroid capsule with lymphovascular invasion and one of two positive lymph nodes. Post-operatively, he underwent 15 cycles of whole brain radiation therapy for a total of 35 Gy. Two additional brain lesions were identified after thyroidectomy and a third was identified after whole brain radiation. He underwent stereotactic radiosurgery of these three lesions less than two months after thyroidectomy. The patient went on to receive modified mantle field irradiation (46 cycles, total 55.2 Gy) to the neck, thyroid bed, and the upper mediastinum. Additionally, he received chemotherapy with doxorubicin 6-8 weeks and temozolomide for 2 years. Thyroid uptake studies showed minimal residual iodine-avid disease and, in the setting of chemotherapy-induced cytopenias, radioactive iodine treatment was not administered. The patient has currently survived 17 years post-treatment. His persistent, but stable, brain lesions are being followed with serial imaging. He remains clinically and neurologically asymptomatic. Conclusions: This is the first case presenting with long-term survival in a patient with metastatic anaplastic thyroid carcinoma. A multidisciplinary course with early aggressive surgical removal, adjuvant treatment with chemotherapy and radiation, and long term imaging follow up may be an acceptable treatment plan for stable patients. References: Smallridge RC, Ain KB, Asa SL, Bible KC, Brierley JD, Burman KD, et al. American Thyroid Association guidelines for management of patients with anaplastic thyroid cancer. Thyroid. 2012;22(11):1104-39.

scholarly journals Prognostic Factors for Survival in Patients Treated with Multimodal Therapy for Anaplastic Thyroid Cancer

2016 ◽  
Vol 36 (9) ◽  
pp. 4697-4700 ◽  
Author(s):  
LUKAS KÄSMANN ◽  
LOUISA BOLM ◽  
STEFAN JANSSEN ◽  
DIRK RADES
Keyword(s):  
Thyroid Cancer ◽  
Prognostic Factors ◽  
Multimodal Therapy ◽  
Anaplastic Thyroid Cancer

scholarly journals Long-term survival of patients with anaplastic thyroid cancer after multimodal treatment

2020 ◽  
Vol 9 (9) ◽  
pp. 5430-5436
Author(s):  
Haejun Lee ◽  
Soo Young Kim ◽  
Seok-Mo Kim ◽  
Ho-Jin Chang ◽  
Yong Sang Lee ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Multimodal Treatment ◽  
Anaplastic Thyroid Cancer ◽  
Term Survival ◽  
Long Term Survival
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