scholarly journals In vitro experimental study of the relationship between the apparent diffusion coefficient and changes in cellularity and cell morphology

2009 ◽  
Vol 22 (03) ◽  
Author(s):  
Kuroda
Keyword(s):  
Experimental Study ◽  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Cell Morphology ◽  
Apparent Diffusion ◽  
The Relationship

In vitro Evaluation of Arabinoxylan Gels as an Oral Delivery System for Insulin

2012 ◽  
Vol 1487 ◽  
Author(s):  
E. Carvajal-Millan ◽  
C. Berlanga-Reyes ◽  
A. Rascón-Chu ◽  
A. L. Martínez-López ◽  
J. A. Márquez-Escalante ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Delivery System ◽  
Oral Delivery ◽  
Delivery Systems ◽  
Oral Delivery System ◽  
Apparent Diffusion ◽  
Oral Delivery Systems ◽  
Hydrolysis Of

ABSTRACTArabinoxylan gels are receiving increasing attention as oral delivery systems of biomolecules for therapeutic purposes. The aim of this research was to evaluate arabinoxylan gels as an oral delivery system for insulin, representing a painless therapy for diabetics. Gels at two concentrations of arabinoxylan were prepared (2.5 and 3.5 % w/v). One concentration of insulin (0.05 % w/v) entrapped in the arabinoxylan gels was investigated. At the end of gelation elasticity (G’) values were 11 and 20 for gels at 2.5 and 3.5% (w/v) in arabinoxylan, respectively. The presence of insulin in the gels did not affect the values of G’. The apparent diffusion coefficient for insulin decreased from 1.30 x 10-7 to 1.09 x 10-7 cm2/s when the concentration of arabinoxylan in the gel increased from 2.5 to 3.5% (w/v). The percentage of proteolysis for insulin entrapped in the gels at 2.5 and 3.5% in arabinoxylan (w/v) were 35 and 17%, respectively, in relation to 100% hydrolysis of insulin in solution. Results indicate that arabinoxylan gels could be potential candidates as oral delivery systems for insulin.

Can Apparent Diffusion Coefficient Discriminate Ischemic From Nonischemic Livers? A Pilot Experimental Study

2007 ◽  
Vol 39 (8) ◽  
pp. 2643-2646 ◽  
Author(s):  
Q. Liu ◽  
D. Monbaliu ◽  
K. Vekemans ◽  
R. Peeters ◽  
F. De Keyzer ◽  
...  
Keyword(s):  
Experimental Study ◽  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Apparent Diffusion

Abstract WP60: Evaluation of Tissue Reversibility by Relative Apparent Diffusion Coefficient Value in Acute Ischemic Stroke Patients Treated With Successful Thrombectomy

Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
Toshihiro Ueda ◽  
Tatsuro Takada ◽  
Shinji Nogoshi ◽  
Satoshi Takaishi ◽  
Tomohide Yoshie ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
Ischemic Stroke ◽  
Apparent Diffusion Coefficient ◽  
Acute Ischemic Stroke ◽  
Stroke Patients ◽  
Infarcted Area ◽  
Apparent Diffusion Coefficient Value ◽  
Apparent Diffusion ◽  
The Mean ◽  
The Relationship

Background: By recent advance of endovascular thrombectomy, we have often experienced acute ischemic patients who have diffusion weighted imaging (DWI) reversal lesions after earlier successful recanalization. We retrospectively investigated the relationship between apparent diffusion coefficient (ADC) thresholds of tissue infarction and time from onset to recanalization in acute ischemic stroke patients. Methods: We assessed 24 patients who have occlusion of internal carotid artery (n=11) and the main trunk of middle cerebral artery (n=13) and obtained recanalization of TICI2b (n=12) and TICI3 (n=12) by thrombectomy and performed MRI before and after treatment. Relative ADC (rADC) value were calculated for initial DWI lesions and around hypoperfused regions. We evaluated rADC values in infarcted and non-infarcted area and analyzed the relationship between rADC thresholds of tissue infarction and time. Results: The mean time from onset to recanalization was 209 minutes and mean initial NIHSS was 15.4. The mean rADC value was 0.633 in infarcted lesions and 0.905 in non-infarcted area (p<0.001). The thresholds for rADC value for infarction by the area under the curve derived from receiver operating characteristic curve analysis were 0.769 in the area which recanalized under 180 minutes form the onset, 0.792 in that from 180 to 240 minutes, and 0.798 in that over 240 minutes. Conclusion: The estimation of rADC value may be useful in predicting the likelihood of DWI lesion reversal. Marked decreasing of rADC value which is under thresholds of infarction indicated irreversible damage of ischemic tissue regardless of early successful recanalization.

Sign in / Sign up

Export Citation Format

Share Document