scholarly journals On the relationship between the apparent diffusion coefficient and extravascular extracellular volume fraction in human breast cancer

2011 ◽  
Vol 29 (5) ◽  
pp. 630-638 ◽  
Author(s):  
Lori R. Arlinghaus ◽  
Xia Li ◽  
A. Ridwan Rahman ◽  
E. Brian Welch ◽  
Lei Xu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Human Breast Cancer ◽  
Volume Fraction ◽  
Extracellular Volume ◽  
Extracellular Volume Fraction ◽  
Human Breast ◽  
Apparent Diffusion ◽  
The Relationship

scholarly journals NMR Imaging of the Apparent Diffusion Coefficient (ADC) for the Evaluation of Metabolic Suppression and Recovery after Prolonged Cerebral Ischemia

1994 ◽  
Vol 14 (5) ◽  
pp. 723-731 ◽  
Author(s):  
Konstantin-Alexander Hossmann ◽  
Matthias Fischer ◽  
Kurt Bockhorst ◽  
Mathias Hoehn-Berlage
Keyword(s):  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Extracellular Volume ◽  
Induced Hypotension ◽  
Tissue Ph ◽  
Close Relationship ◽  
Apparent Diffusion ◽  
Internal Mammary ◽  
Systemic Variables ◽  
Postischemic Recovery

Adult normothermic cats were submitted to 1-h complete cerebrocirculatory arrest by intrathoracic occlusion of the internal mammary, the innominate, and the subclavian arteries in combination with pharmacologically induced hypotension. After ischemia, recirculation was initiated at different blood pressure levels to manipulate the postischemia resuscitation conditions. The resulting spectrum of postischemic recovery was studied by combining nuclear magnetic resonance imaging of the apparent diffusion coefficient (ADC) with pictorial assays of brain tissue pH, ATP, glucose, and lactate. Before ischemia, the mean ADC (average of seven coronal slices of five cats) was 713 ± 40 × 10−6 mm2/s. After 10-min ischemia, ADC declined to 68% of control and after 50 min slightly further to 63% of control. During recirculation after 1-h ischemia, recovery of ADC varied depending on the initial reperfusion pressure and other systemic variables. In two animals ADC only transiently increased followed by a secondary decline below the postischemic level. In three other animals ADC returned to near control within 1 h of recirculation. The comparison of ADC changes with previously reported changes in extracellular volume revealed a close relationship, supporting the notion that ADC is a function of the intra/extracellular water compartmentation. Recovery of ADC correlated closely with tissue pH and metabolic recovery, studied 3 h after the initiation of recirculation. Animals without recovery of ADC exhibited global depletion of ATP and glucose and severe lactacidosis, whereas animals with recovery of ADC showed replenishment of ATP and glucose to near control and a substantial reversal of lactacidosis. Our data demonstrate that imaging of ADC provides reliable information about the metabolic state of the brain and can be used to monitor, with high temporal and regional resolution, the manifestation and reversal of ischemic brain injury.

scholarly journals Erratum

2017 ◽  
Vol 59 (6) ◽  
pp. NP11-NP11
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Myocardial Fibrosis ◽  
Lupus Erythematosus ◽  
Extracellular Volume ◽  
Strongly Correlated ◽  
Systemic Lupus ◽  
Apparent Diffusion

Wu R, An DA, Hu J, et al. The apparent diffusion coefficient is strongly correlated with extracellular volume, a measure of myocardial fibrosis, and subclinical cardiomyopathy in patients with systemic lupus erythematosus. Acta Radiol 2017. DOI: 10.1177/0284185117717763. In the above-referenced article, the corresponding author was wrongly listed as “Lian-Ming Wu” in the initial OnlineFirst version. The online and print versions have been updated to reflect the correct corresponding author, “Jian-Rong Xu.”

Apparent diffusion coefficient: Potential biomarker for complete response after neo‐adjuvant chemotherapy in breast cancer

2019 ◽  
Vol 26 (2) ◽  
pp. 306-308
Author(s):  
Lucia Graña‐López ◽  
Michel Herranz ◽  
Fiz Andrés Maciñeira ◽  
Ángeles Villares ◽  
Manuel Vázquez‐Caruncho
Keyword(s):  
Breast Cancer ◽  
Diffusion Coefficient ◽  
Adjuvant Chemotherapy ◽  
Apparent Diffusion Coefficient ◽  
Complete Response ◽  
Potential Biomarker ◽  
Apparent Diffusion ◽  
Neo Adjuvant Chemotherapy
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