In vitro Evaluation of Arabinoxylan Gels as an Oral Delivery System for Insulin

2012 ◽  
Vol 1487 ◽  
Author(s):  
E. Carvajal-Millan ◽  
C. Berlanga-Reyes ◽  
A. Rascón-Chu ◽  
A. L. Martínez-López ◽  
J. A. Márquez-Escalante ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Delivery System ◽  
Oral Delivery ◽  
Delivery Systems ◽  
Oral Delivery System ◽  
Apparent Diffusion ◽  
Oral Delivery Systems ◽  
Hydrolysis Of

ABSTRACTArabinoxylan gels are receiving increasing attention as oral delivery systems of biomolecules for therapeutic purposes. The aim of this research was to evaluate arabinoxylan gels as an oral delivery system for insulin, representing a painless therapy for diabetics. Gels at two concentrations of arabinoxylan were prepared (2.5 and 3.5 % w/v). One concentration of insulin (0.05 % w/v) entrapped in the arabinoxylan gels was investigated. At the end of gelation elasticity (G’) values were 11 and 20 for gels at 2.5 and 3.5% (w/v) in arabinoxylan, respectively. The presence of insulin in the gels did not affect the values of G’. The apparent diffusion coefficient for insulin decreased from 1.30 x 10-7 to 1.09 x 10-7 cm2/s when the concentration of arabinoxylan in the gel increased from 2.5 to 3.5% (w/v). The percentage of proteolysis for insulin entrapped in the gels at 2.5 and 3.5% in arabinoxylan (w/v) were 35 and 17%, respectively, in relation to 100% hydrolysis of insulin in solution. Results indicate that arabinoxylan gels could be potential candidates as oral delivery systems for insulin.

Chitosan and Quercetin: Potential Hand in Hand Encountering Tumors in Oral Delivery System

2019 ◽  
Vol 25 (28) ◽  
pp. 3074-3086
Author(s):  
Jalil Rashedi ◽  
Amir Ghorbanihaghjo ◽  
Mohammad Asgharzadeh ◽  
Behzad Baradaran
Keyword(s):  
Physicochemical Properties ◽  
Delivery System ◽  
Oral Delivery ◽  
Delivery Systems ◽  
Target Site ◽  
Cross Linking ◽  
Oral Delivery System ◽  
Polymeric Compounds ◽  
Oral Delivery Systems ◽  
Natural And Synthetic

: Chitosan is a cationic polysaccharide and multi-potential polymer with the ability to interact with other natural and synthetic polyanionic/polymeric compounds, with or without a cross-linking agent. It has been able to composite nano-microparticles with a variety of features. This compound has the ability to carry quercetin, as an anti-tumor subject, through the various epithelial systems and release in the sustained and controlled state to the target site. : This paper reviews published studies on detailed physicochemical properties of chitosan and quercetin in the fight against the tumor. This also focused on how the chitosan polymer interacts with other polymeric and polyanion species in order to improve its efficiency to make a more suitable capsule or matrix for a variety of drugs, especially quercetin, in oral delivery systems.

scholarly journals Fabrication of PLA-PEG Nanoparticles as Delivery Systems for Improved Stability and Controlled Release of Catechin

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Neha Atulkumar Singh ◽  
Abul Kalam Azad Mandal ◽  
Zaved Ahmed Khan
Keyword(s):  
Controlled Release ◽  
Delivery System ◽  
Oral Delivery ◽  
Polymeric Nanoparticles ◽  
Double Emulsion ◽  
Hydrodynamic Diameter ◽  
Sem Image ◽  
Oral Delivery System ◽  
Improved Stability

The purpose of this study was to develop an oral delivery system for the controlled release of catechin and evaluate the antioxidant potential and stability of catechin loaded PLA/PEG nanoparticles (CATNP). Nanoparticles were synthesized using a double emulsion solvent evaporation method. The fabricated nanoparticles were relatively small with a hydrodynamic diameter of 300 nm and an encapsulation efficiency of 95%. SEM image analysis showed uniform sized and spherically shaped nanoparticles. In vitro release profiles indicated a slow and sustained release of catechin from the nanoparticle. Stability of the nanoparticle in simulated gastric and intestinal fluids is maintained due to the PEG coating on the nanoparticles, which effectively protected catechin against gastrointestinal enzyme activity. Enhanced inhibition action of free radicals and metal chelation potential was noted when catechin was encapsulated in these polymeric nanoparticles. The reports obtained from this study would provide an opportunity for designing an oral delivery system aimed at inhibiting oxidative stress in the human body.

In vitro evaluation of glycol chitosan based formulations as oral delivery systems for efflux pump inhibition

2017 ◽  
Vol 166 ◽  
pp. 73-82 ◽  
Author(s):  
Delia Mandracchia ◽  
Adriana Trapani ◽  
Giuseppe Tripodo ◽  
Maria Grazia Perrone ◽  
Gaetano Giammona ◽  
...  
Keyword(s):  
Oral Delivery ◽  
Efflux Pump ◽  
Delivery Systems ◽  
Glycol Chitosan ◽  
In Vitro Evaluation ◽  
Efflux Pump Inhibition ◽  
Oral Delivery Systems

Development of antioxidant gliadin particle stabilized Pickering high internal phase emulsions (HIPEs) as oral delivery systems and the in vitro digestion fate

2018 ◽  
Vol 9 (2) ◽  
pp. 959-970 ◽  
Author(s):  
F. Z. Zhou ◽  
T. Zeng ◽  
S. W. Yin ◽  
C. H. Tang ◽  
D. B. Yuan ◽  
...  
Keyword(s):  
Lipid Oxidation ◽  
Chemical Stability ◽  
Oral Delivery ◽  
In Vitro Digestion ◽  
Delivery Systems ◽  
Algal Oil ◽  
Internal Phase ◽  
First Time ◽  
Oral Delivery Systems

In this paper, we demonstrate for the first time the use of gliadin particles to structure algal oil (rich in DHA) and to exert chemical stability against lipid oxidation via the Pickering high internal phase emulsion (HIPE) strategy.

scholarly journals Oral cyclosporine A - the current picture of its liposomal and other delivery systems

2009 ◽  
Vol 14 (1) ◽  
Author(s):  
Aleksander Czogalla
Keyword(s):  
Autoimmune Diseases ◽  
Physicochemical Properties ◽  
Organ Transplantation ◽  
Delivery System ◽  
Cyclosporine A ◽  
Lipid Membranes ◽  
Oral Delivery ◽  
Delivery Systems ◽  
Oral Delivery System ◽  
Low Solubility

AbstractThe discovery of cyclosporine A was a milestone in organ transplantation and the treatment of autoimmune diseases. However, developing an efficient oral delivery system for this drug is complicated by its poor biopharmaceutical characteristics (low solubility and permeability) and the need to carefully monitor its levels in the blood. Current research is exploring various approaches, including those based on emulsions, microspheres, nanoparticles, and liposomes. Although progress has been made, none of the formulations is flawless. This review is a brief description of the main pharmaceutical systems and devices that have been described for the oral delivery of cyclosporine A in the context of the physicochemical properties of the drug and the character of its interactions with lipid membranes.

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