scholarly journals Influence of miR‑101 on proliferation of liver cancer cells through the MAPK/ERK signaling pathway

2019 ◽  
Author(s):  
Xuan Meng ◽  
Yong Shi ◽  
Xin Xiang ◽  
Chonghui Li ◽  
Xinlan Ge ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Erk Signaling ◽  
Liver Cancer Cells

scholarly journals Anticancer property of Hemp Bioactive Peptides in Hep3B liver cancer cells through Akt/GSK3β/β‐catenin signaling pathway

2021 ◽  
Vol 9 (4) ◽  
pp. 1833-1841
Author(s):  
Lian‐Hui Wei ◽  
Yan Dong ◽  
Yu‐Feng Sun ◽  
Xue‐Song Mei ◽  
Xue‐Song Ma ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Bioactive Peptides ◽  
Liver Cancer Cells

Inhibition of PI3K/Akt and ERK signaling decreases visfatin-induced invasion in liver cancer cells

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Candace Miethe ◽  
Linda Torres ◽  
Megan Zamora ◽  
Ramona S. Price
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Signaling Pathways ◽  
Fatty Acid Synthase ◽  
Erk Signaling ◽  
Ros Production ◽  
Nicotinamide Phosphoribosyltransferase ◽  
Liver Cancer Cells ◽  
Phosphorylated Akt ◽  
Erk Inhibition

Abstract Objectives Visfatin is found in adipose tissue and is referred to as nicotinamide phosphoribosyltransferase (Nampt). Visfatin has anti-apoptotic, proliferative, and metastatic properties and may mediate its effects via ERK and PI3K/Akt signaling. Studies have yet to determine whether inhibition of kinase signaling will suppress visfatin-induced liver cancer. The purpose of this study was to determine which signaling pathways visfatin may promote liver cancer progression. Methods HepG2 and SNU-449 liver cancer cells were exposed to visfatin with or without ERK or PI3K/Akt inhibitor, or both inhibitors combined. These processes that were assessed: proliferation, reactive oxygen species (ROS), lipogenesis, invasion, and matrix metalloproteinase (MMP). Results Inhibition of PI3K/Akt and combination of inhibitors suppressed visfatin-induced viability. ERK inhibition in HepG2 cells decreased visfatin-induced proliferation. ERK inhibitor alone or in combination with PI3K inhibitors effectively suppressed MMP-9 secretion and invasion in liver cancer cells. PI3K and ERK inhibition and PI3K inhibition alone blocked visfatin’s ROS production in SNU-449 cells. These results corresponded with a decrease in phosphorylated Akt and ERK, β-catenin, and fatty acid synthase. Conclusions Akt and ERK inhibition differentially regulated physiological changes in liver cancer cells. Inhibition of Akt and ERK signaling pathways suppressed visfatin-induced invasion, viability, MMP-9 activation, and ROS production.

scholarly journals Sorafenib kills liver cancer cells by disrupting SCD1‐mediated synthesis of monounsaturated fatty acidsviathe ATP‐AMPK‐mTOR‐SREBP1 signaling pathway

2019 ◽  
Vol 33 (9) ◽  
pp. 10089-10103 ◽  
Author(s):  
Ge Liu ◽  
Shan Kuang ◽  
Ruobing Cao ◽  
Ju Wang ◽  
Quancai Peng ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Liver Cancer Cells

Effect of Bmi-1-mediated NF-κB signaling pathway on the stem-like properties of CD133+ human liver cancer cells

2018 ◽  
Vol 22 (3) ◽  
pp. 575-585 ◽  
Author(s):  
De-Qiang Ma ◽  
Yin-Hua Zhang ◽  
De-Ping Ding ◽  
Juan Li ◽  
Lin-Li Chen ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Human Liver ◽  
Liver Cancer Cells ◽  
Human Liver Cancer ◽  
Human Liver Cancer Cells

scholarly journals SP-8356, a (1S)-(-)-Verbenone Derivative, Inhibits the Growth and Motility of Liver Cancer Cells by Regulating NF-κB and ERK Signaling

2021 ◽  
Author(s):  
Dong Hwi Kim ◽  
Hyo Jeong Yong ◽  
Sunam Mander ◽  
Huong Thi Nguyen ◽  
Lan Phuong Nguyen ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Erk Signaling ◽  
Liver Cancer Cells
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