scholarly journals Dichloroacetate enhances the antitumor effect of pirarubicin via regulating the ROS-JNK signaling pathway in liver cancer cells

2020 ◽  
Author(s):  
Xiao-Jing Yan ◽  
Peng Xie ◽  
Xu-Fang Dai ◽  
Ling-Xi Chen ◽  
Liang-Bo Sun ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Antitumor Effect ◽  
Jnk Signaling ◽  
Liver Cancer Cells ◽  
Jnk Signaling Pathway

scholarly journals Anticancer property of Hemp Bioactive Peptides in Hep3B liver cancer cells through Akt/GSK3β/β‐catenin signaling pathway

2021 ◽  
Vol 9 (4) ◽  
pp. 1833-1841
Author(s):  
Lian‐Hui Wei ◽  
Yan Dong ◽  
Yu‐Feng Sun ◽  
Xue‐Song Mei ◽  
Xue‐Song Ma ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Bioactive Peptides ◽  
Liver Cancer Cells

scholarly journals Sorafenib kills liver cancer cells by disrupting SCD1‐mediated synthesis of monounsaturated fatty acidsviathe ATP‐AMPK‐mTOR‐SREBP1 signaling pathway

2019 ◽  
Vol 33 (9) ◽  
pp. 10089-10103 ◽  
Author(s):  
Ge Liu ◽  
Shan Kuang ◽  
Ruobing Cao ◽  
Ju Wang ◽  
Quancai Peng ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Liver Cancer Cells

Effect of Bmi-1-mediated NF-κB signaling pathway on the stem-like properties of CD133+ human liver cancer cells

2018 ◽  
Vol 22 (3) ◽  
pp. 575-585 ◽  
Author(s):  
De-Qiang Ma ◽  
Yin-Hua Zhang ◽  
De-Ping Ding ◽  
Juan Li ◽  
Lin-Li Chen ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Human Liver ◽  
Liver Cancer Cells ◽  
Human Liver Cancer ◽  
Human Liver Cancer Cells

Promising antitumor effect of alpha-tocopheryl succinate in human colon and liver cancer cells

2011 ◽  
Vol 21 (10) ◽  
pp. 2735-2743 ◽  
Author(s):  
Amal A. Abd-El Fattah ◽  
Hebatallah A. Darwish ◽  
Nevine Fathy ◽  
Amira Raafat ◽  
Samia A. Shouman
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Antitumor Effect ◽  
Human Colon ◽  
Liver Cancer Cells ◽  
Tocopheryl Succinate

scholarly journals Targeting the JNK Signaling Pathway Potentiates the Antiproliferative Efficacy of Rapamycin in LS174T Colon Cancer Cells

2011 ◽  
Vol 167 (2) ◽  
pp. e193-e198 ◽  
Author(s):  
Michael Benoit ◽  
Anne Dormond-Meuwly ◽  
Nicolas Demartines ◽  
Olivier Dormond
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Colon Cancer Cells ◽  
Jnk Signaling ◽  
Jnk Signaling Pathway

miRNA-206 Regulates EVI1 Gene Expression, Akt Signaling Pathway and Cell Biological Behavior in Gastric Cancer Cells

2019 ◽  
Vol 9 (10) ◽  
pp. 1381-1387
Author(s):  
Wanjun Jia ◽  
Yabin Zhang ◽  
Ruian Wang
Keyword(s):  
Gene Expression ◽  
Gastric Cancer ◽  
Cell Proliferation ◽  
Targeted Therapy ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Biological Behavior ◽  
Gastric Cancer Cells ◽  
Jnk Signaling ◽  
Jnk Signaling Pathway

To investigate the impact of miRNA-206 on the transcriptional expression of EVI1 gene and activation of Akt/JNK signaling pathway in gastric cancer cells, and to provide a new idea for gene-targeted therapy of gastric cancer. The miRNA-206 transfection experiment was firstly used to verify the regulation of EVI1. The experiment was divided into three groups: miRNA-206 mimics (100 nM), miRNA-206 inhibitor (100 nM), miR-NC (100 nM), and transfected into gastric cancer cells sgc7901, Western blot. EVI1 protein expression was detected; then the signal transduction and biological behavior of the cells were verified by miRNA-206 lentiviral vector transfection experiments. The experiment was divided into three groups: pLB-miRNA-206 group, empty vector group and control group (sgc7901 cell group). miRNA-206 and EVI1 mRNA levels were detected by real-time fluorescence quantitative (RT-PCR), and p-Akt and p-JNK were detected by Western blot. Protein expression, cell proliferation was quantified by MTT assay, and the alteration of cell cycle were detected by flow cytometry. miRNA-206 may affect the cell proliferation and division cycle by targeting the regulation of EVI1 transcriptional gene expression and activation of Akt/JNK signaling pathway in gastric cancer cells, and it is expected to provide an important selection site for gene-targeted therapy of gastric cancer.

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