scholarly journals Anticancer property of Hemp Bioactive Peptides in Hep3B liver cancer cells through Akt/GSK3β/β‐catenin signaling pathway

2021 ◽  
Vol 9 (4) ◽  
pp. 1833-1841
Author(s):  
Lian‐Hui Wei ◽  
Yan Dong ◽  
Yu‐Feng Sun ◽  
Xue‐Song Mei ◽  
Xue‐Song Ma ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Bioactive Peptides ◽  
Liver Cancer Cells

scholarly journals Sorafenib kills liver cancer cells by disrupting SCD1‐mediated synthesis of monounsaturated fatty acidsviathe ATP‐AMPK‐mTOR‐SREBP1 signaling pathway

2019 ◽  
Vol 33 (9) ◽  
pp. 10089-10103 ◽  
Author(s):  
Ge Liu ◽  
Shan Kuang ◽  
Ruobing Cao ◽  
Ju Wang ◽  
Quancai Peng ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Liver Cancer Cells

Effect of Bmi-1-mediated NF-κB signaling pathway on the stem-like properties of CD133+ human liver cancer cells

2018 ◽  
Vol 22 (3) ◽  
pp. 575-585 ◽  
Author(s):  
De-Qiang Ma ◽  
Yin-Hua Zhang ◽  
De-Ping Ding ◽  
Juan Li ◽  
Lin-Li Chen ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Human Liver ◽  
Liver Cancer Cells ◽  
Human Liver Cancer ◽  
Human Liver Cancer Cells

scholarly journals Influence of miR‑101 on proliferation of liver cancer cells through the MAPK/ERK signaling pathway

2019 ◽  
Author(s):  
Xuan Meng ◽  
Yong Shi ◽  
Xin Xiang ◽  
Chonghui Li ◽  
Xinlan Ge ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Erk Signaling ◽  
Liver Cancer Cells

scholarly journals Apatinib Inhibits the Invasion and Metastasis of Liver Cancer Cells by Downregulating MMP-Related Proteins via Regulation of the NF-κB Signaling Pathway

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Xiaoxiao He ◽  
Zaozao Huang ◽  
Ping Liu ◽  
Qiuting Li ◽  
Mengmeng Wang ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Cell Lines ◽  
Inhibitory Effect ◽  
Control Group ◽  
Invasion And Metastasis ◽  
Expression Levels ◽  
Liver Cancer Cells

Objective. We aimed to investigate whether apatinib has an inhibitory effect on the invasion and metastasis of liver cancer in vitro. Methods. The anti-invasion and antimetastasis effects of apatinib in HepG2, Hep3B,Huh7 and SMMC-7721 liver cancer cell lines were tested by the wound-healing and transwell invasion assays. Real-time PCR and Western blot were used to detect the influence of apatinib on the gene expression of MMPs, TIMPs, and constituents of the NF-κB signaling pathway in Hep3B and HepG2 liver cell lines. Results. Apatinib has a significant inhibitory effect on the metastasis and invasion of liver cancer cells. The expression levels of MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-10, MMP-11, and MMP-16 were downregulated, while the expression levels of TIMP-3 and TIMP-4 were upregulated by apatinib treatment at both the mRNA and protein levels. The phosphorylation of IκBα and NF-κB p65 was significantly reduced compared with that in the control group. Conclusions. Apatinib inhibits the invasion and metastasis of human liver cancer cells by downregulating the expression of MMP-related genes. This may be achieved by inhibiting the activation of the NF-κB signaling pathway.

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