scholarly journals Role of C-X-C chemokine ligand 12/C-X-C chemokine receptor 4 in the progression of hepatocellular carcinoma

2017 ◽  
Vol 14 (2) ◽  
pp. 1905-1910 ◽  
Author(s):  
Kuo-Shyang Jeng ◽  
Chi-Juei Jeng ◽  
Wen-Juei Jeng ◽  
Chiung-Fang Chang ◽  
I-Shyan Sheen
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chemokine Receptor ◽  
Chemokine Ligand ◽  
Chemokine Receptor 4

scholarly journals The role of CC-chemokine receptor 4 in murine polymicrobial sepsis

Critical Care ◽  
2007 ◽  
Vol 11 (Suppl 4) ◽  
pp. P14
Author(s):  
Stefan Maier ◽  
Tobias Traeger ◽  
Wolfram Keßler ◽  
Pia Körner ◽  
Hendrik Mehmcke ◽  
...  
Keyword(s):  
Chemokine Receptor ◽  
Polymicrobial Sepsis ◽  
Cc Chemokine ◽  
Chemokine Receptor 4

scholarly journals Identification of human CCR8 as a CCL18 receptor

2013 ◽  
Vol 210 (10) ◽  
pp. 1889-1898 ◽  
Author(s):  
Sabina A. Islam ◽  
Morris F. Ling ◽  
John Leung ◽  
Wayne G. Shreffler ◽  
Andrew D. Luster
Keyword(s):  
Chemokine Receptor ◽  
Inflammatory Diseases ◽  
Calcium Flux ◽  
Th2 Cells ◽  
Wild Type ◽  
Transfected Cells ◽  
Esophageal Tissue ◽  
Chemokine Ligand ◽  
Normal Controls

The CC chemokine ligand 18 (CCL18) is one of the most highly expressed chemokines in human chronic inflammatory diseases. An appreciation of the role of CCL18 in these diseases has been hampered by the lack of an identified chemokine receptor. We report that the human chemokine receptor CCR8 is a CCL18 receptor. CCL18 induced chemotaxis and calcium flux of human CCR8-transfected cells. CCL18 bound with high affinity to CCR8 and induced its internalization. Human CCL1, the known endogenous CCR8 ligand, and CCL18 competed for binding to CCR8-transfected cells. Further, CCL1 and CCL18 induced heterologous cross-desensitization of CCR8-transfected cells and human Th2 cells. CCL18 induced chemotaxis and calcium flux of human activated highly polarized Th2 cells through CCR8. Wild-type but not Ccr8-deficient activated mouse Th2 cells migrated in response to CCL18. CCL18 and CCR8 were coexpressed in esophageal biopsy tissue from individuals with active eosinophilic esophagitis (EoE) and were present at markedly higher levels compared with esophageal tissue isolated from EoE patients whose disease was in remission or in normal controls. Identifying CCR8 as a chemokine receptor for CCL18 will help clarify the biological role of this highly expressed chemokine in human disease.

scholarly journals The role of chemokine receptor 9/chemokine ligand 25 signaling: From immune cells to cancer cells (Review)

2018 ◽  
Author(s):  
Cong Wang ◽  
Zhenghuan Liu ◽  
Zhihui Xu ◽  
Xian Wu ◽  
Dongyang Zhang ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Chemokine Receptor ◽  
Immune Cells ◽  
Chemokine Ligand

scholarly journals Preferential involvement of CX chemokine receptor 4 and CX chemokine ligand 12 in T-Cell migration toward melanoma cells

2006 ◽  
Vol 5 (10) ◽  
pp. 1304-1312 ◽  
Author(s):  
Tianqian Zhang ◽  
Rajasekharan Somasundaram ◽  
Carol Berking ◽  
Laura Caputo ◽  
Patricia Van Belle ◽  
...  
Keyword(s):  
Cell Migration ◽  
T Cell ◽  
Chemokine Receptor ◽  
Melanoma Cells ◽  
T Cell Migration ◽  
Chemokine Ligand ◽  
Chemokine Receptor 4

The role of CXC chemokine ligand (CXCL)12-CXC chemokine receptor (CXCR)4 signalling in the migration of neural stem cells towards a brain tumour

2009 ◽  
Vol 35 (6) ◽  
pp. 579-591 ◽  
Author(s):  
A. A. E. van der Meulen ◽  
K. Biber ◽  
S. Lukovac ◽  
V. Balasubramaniyan ◽  
W. F. A. den Dunnen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Brain Tumour ◽  
Chemokine Receptor ◽  
Cxc Chemokine ◽  
Chemokine Ligand
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