scholarly journals Loss of atypical chemokine receptor 4 facilitates C‑C motif chemokine ligand 21‑mediated tumor growth and invasion in nasopharyngeal carcinoma

2018 ◽  
Author(s):  
Yunhe Ju ◽  
Chuanzheng Sun ◽  
Xiaoli Wang
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Tumor Growth ◽  
Chemokine Receptor ◽  
Chemokine Ligand ◽  
Chemokine Receptor 4 ◽  
Tumor Growth And Invasion

scholarly journals PTPRG suppresses tumor growth and invasion via inhibition of Akt signaling in nasopharyngeal carcinoma

Oncotarget ◽  
2015 ◽  
Vol 6 (15) ◽  
pp. 13434-13447 ◽  
Author(s):  
Arthur Kwok Leung Cheung ◽  
Joseph Chok Yan Ip ◽  
Adrian Chi Hang Chu ◽  
Yue Cheng ◽  
Merrin Man Long Leong ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Tumor Growth ◽  
Akt Signaling ◽  
Tumor Growth And Invasion

scholarly journals Role of C-X-C chemokine ligand 12/C-X-C chemokine receptor 4 in the progression of hepatocellular carcinoma

2017 ◽  
Vol 14 (2) ◽  
pp. 1905-1910 ◽  
Author(s):  
Kuo-Shyang Jeng ◽  
Chi-Juei Jeng ◽  
Wen-Juei Jeng ◽  
Chiung-Fang Chang ◽  
I-Shyan Sheen
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chemokine Receptor ◽  
Chemokine Ligand ◽  
Chemokine Receptor 4

scholarly journals Preferential involvement of CX chemokine receptor 4 and CX chemokine ligand 12 in T-Cell migration toward melanoma cells

2006 ◽  
Vol 5 (10) ◽  
pp. 1304-1312 ◽  
Author(s):  
Tianqian Zhang ◽  
Rajasekharan Somasundaram ◽  
Carol Berking ◽  
Laura Caputo ◽  
Patricia Van Belle ◽  
...  
Keyword(s):  
Cell Migration ◽  
T Cell ◽  
Chemokine Receptor ◽  
Melanoma Cells ◽  
T Cell Migration ◽  
Chemokine Ligand ◽  
Chemokine Receptor 4

scholarly journals miR-216b suppresses tumor growth and invasion by targeting KRAS in nasopharyngeal carcinoma

2011 ◽  
Vol 124 (17) ◽  
pp. 2997-3005 ◽  
Author(s):  
Min Deng ◽  
Hailin Tang ◽  
Yanhong Zhou ◽  
Ming Zhou ◽  
Wei Xiong ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Tumor Growth ◽  
Tumor Growth And Invasion

scholarly journals Adaptive Immunodeficiency in WHIM Syndrome

2018 ◽  
Vol 20 (1) ◽  
pp. 3 ◽  
Author(s):  
Shamik Majumdar ◽  
Philip Murphy
Keyword(s):  
Chemokine Receptor ◽  
Autosomal Dominant ◽  
Whim Syndrome ◽  
C Terminus ◽  
Immunodeficiency Disorder ◽  
Chemokine Ligand ◽  
Chemokine Receptor 4 ◽  
The Impact ◽  
G Protein Coupled ◽  
Increased Susceptibility

Cysteine-X-cysteine chemokine receptor 4 (CXCR4) is a broadly expressed and multifunctional G protein-coupled chemokine receptor critical for organogenesis, hematopoiesis, and antimicrobial host defense. In the hematopoietic system, the binding of CXCR4 to its cognate chemokine ligand, CXCL12, mediates leukocyte trafficking, distribution, survival, activation, and proliferation. Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome is a rare, autosomal dominant, combined immunodeficiency disorder caused by mutations in the C-terminus of CXCR4 that prevent receptor downregulation and therefore result in pathologically increased signaling. The “M” in the acronym WHIM refers to myelokathexis, the retention of neutrophils in the bone marrow resulting in neutropenia, which explains in part the increased susceptibility to bacterial infection. However, WHIM patients also present with B and T lymphopenia, which may explain the susceptibility to human papillomavirus (HPV), the cause of warts. The impact of WHIM mutations on lymphocytes and adaptive immunity has received less attention than myelokathexis and is the focus of this review.

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