scholarly journals The role of CC-chemokine receptor 4 in murine polymicrobial sepsis

Critical Care ◽  
2007 ◽  
Vol 11 (Suppl 4) ◽  
pp. P14
Author(s):  
Stefan Maier ◽  
Tobias Traeger ◽  
Wolfram Keßler ◽  
Pia Körner ◽  
Hendrik Mehmcke ◽  
...  
Keyword(s):  
Chemokine Receptor ◽  
Polymicrobial Sepsis ◽  
Cc Chemokine ◽  
Chemokine Receptor 4

scholarly journals Detrimental Role of CC Chemokine Receptor 4 in Murine Polymicrobial Sepsis

2008 ◽  
Vol 76 (11) ◽  
pp. 5285-5293 ◽  
Author(s):  
Tobias Traeger ◽  
Wolfram Kessler ◽  
Volker Assfalg ◽  
Katharina Cziupka ◽  
Pia Koerner ◽  
...  
Keyword(s):  
Chemokine Receptor ◽  
Survival Rates ◽  
Lavage Fluid ◽  
Abdominal Sepsis ◽  
Polymicrobial Sepsis ◽  
Cc Chemokine ◽  
Chemokine Receptor 4 ◽  
Colon Ascendens ◽  
First Time

ABSTRACT CC chemokine receptor 4 (CCR4) and its two ligands, CCL17 and CCL22, are critically involved in different immune processes. In models of lipopolysaccharide-induced shock, CCR4-deficient (CCR4−/−) mice showed improved survival rates associated with attenuated proinflammatory cytokine release. Using CCR4−/− mice with a C57BL/6 background, this study describes for the first time the role of CCR4 in a murine model of polymicrobial abdominal sepsis, the colon ascendens stent peritonitis (CASP). CASP-induced sepsis led to a massive downregulation of CCR4 in lymphoid and nonlymphoid tissues, whereas the expression of CCL17 and CCL22 was independent of the presence of CCR4. After CASP, CCR4−/− animals showed a strongly enhanced bacterial clearance in several organs but not in the peritoneal lavage fluid and the blood. In addition, significantly reduced levels of proinflammatory cytokines/chemokines were measured in organ supernatants as well as in the sera of CCR4−/− mice. CCR4 deficiency consequently resulted in an attenuated severity of systemic sepsis and a strongly improved survival rate after CASP or CASP with intervention. Thus, our data provide clear evidence that CCR4 plays a strictly detrimental role in the course of polymicrobial sepsis.

scholarly journals Role of CC Chemokine Receptor 4 in Natural Killer Cell Activation during Acute Cigarette Smoke Exposure

2014 ◽  
Vol 184 (2) ◽  
pp. 454-463 ◽  
Author(s):  
Valerie R. Stolberg ◽  
Brian Martin ◽  
Peter Mancuso ◽  
Michal A. Olszewski ◽  
Christine M. Freeman ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Cigarette Smoke ◽  
Chemokine Receptor ◽  
Cell Activation ◽  
Killer Cell ◽  
Cigarette Smoke Exposure ◽  
Cc Chemokine ◽  
Chemokine Receptor 4

scholarly journals Chemokine-like factor 1 is a functional ligand for CC chemokine receptor 4 (CCR4)

Life Sciences ◽  
2006 ◽  
Vol 78 (6) ◽  
pp. 614-621 ◽  
Author(s):  
Ying Wang ◽  
Yingmei Zhang ◽  
Xue Yang ◽  
Wenling Han ◽  
Yanan Liu ◽  
...  
Keyword(s):  
Chemokine Receptor ◽  
Cc Chemokine ◽  
Chemokine Receptor 4

Suppressive effects of a novel CC chemokine receptor 4 antagonist on Th2 cell trafficking in ligand- and antigen-induced mouse models

2013 ◽  
Vol 720 (1-3) ◽  
pp. 335-343 ◽  
Author(s):  
Takaki Komiya ◽  
Tetsuya Sugiyama ◽  
Kazuhiko Takeda ◽  
Noriki Watanabe ◽  
Masamichi Imai ◽  
...  
Keyword(s):  
Mouse Models ◽  
Chemokine Receptor ◽  
Cell Trafficking ◽  
Cc Chemokine ◽  
Th2 Cell ◽  
Chemokine Receptor 4

CC chemokine receptor 4

1997 ◽  
pp. 165-166
Author(s):  
Krishna Vaddi ◽  
Margaret Keller ◽  
Robert C. Newton
Keyword(s):  
Chemokine Receptor ◽  
Cc Chemokine ◽  
Chemokine Receptor 4
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